2. Academic Validation
  3. Overexpressed ITGA2 contributes to paclitaxel resistance by ovarian cancer cells through the activation of the AKT/FoxO1 pathway

Overexpressed ITGA2 contributes to paclitaxel resistance by ovarian cancer cells through the activation of the AKT/FoxO1 pathway

  • Aging (Albany NY). 2020 Mar 22;12(6):5336-5351. doi: 10.18632/aging.102954.
Linlin Ma 1,  Yan Sun 2 3,  Dan Li 4,  Hansong Li 1,  Xin Jin 3 5,  Dianyun Ren 2 3
Affiliations

Affiliations

  • 1 Department of Obstetrics and Gynecology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, R.P. China.
  • 2 Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • 3 Sino-German Laboratory of Personalized Medicine for Pancreatic Cancer, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • 4 Cardiovascular Medicine Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
  • 5 Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
PMID: 32202508 DOI: 10.18632/aging.102954
Abstract

Ovarian Cancer is one of the most malignant tumors of the female reproductive system, with high invasiveness. The disease is a severe threat to women's health. The ITGA2 gene, which codes for Integrin subunit α2, is involved in the proliferation, invasion, and metastasis of Cancer cells. Although previous studies have shown that ITGA2 increases in ovarian Cancer, the specific molecular mechanism of how ITGA2 promotes ovarian Cancer proliferation and metastasis is still unclear. In this study, we confirmed that ITGA2 was elevated in ovarian Cancer, which led to poor prognosis and survival. Overexpressed ITGA2 promoted the proliferation of ovarian Cancer cells. We also found that ITGA2 regulated the phosphorylation of forkhead box O1 (FoxO1) by mediating Akt phosphorylation, which provided a reasonable explanation for ITGA2's role in ovarian cancer's resistance to albumin paclitaxel. In summary, ITGA2 could be used as a new therapeutic target and prognostic indicator in ovarian Cancer.

Keywords

PTX resistance; forkhead box O1 (FoxO1); integrin subunit α2 (ITGA2); p-AKT.

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