nsp12-IN-1 

Nsp12-IN-1 is a nucleoside analogue. Nsp12-IN-1 can block the synthesis of viral RNA and inhibit viral replication. Nsp12-IN-1 can be used in the study of pan-coronavirus^[1].

Nsp12-IN-1 has a high selectivity index and is less toxic to cells at effective antiviral concentrations, showing antiviral activity against SARS-CoV-2^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nsp12-IN-1 (2 mg/kg, i.v.; 30mg/kg p.o.; 24h) improves oral bioavailability, but the absolute bioavailability of these compounds remains low in female Balb-c mice^[1].

Pharmacokinetic Analysis in female Balb-c mice^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

341.30

C₁₃H₁₆FN₅O₅

O[C@H]1[C@@H](O)[C@H](C2=CC(C(N)=O)=C3C(N)=NC(CF)=NN32)O[C@@H]1CO

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mesaros E F, Dugan B J, Gao M, et al. Discovery of C-Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV-2[J]. ACS Infectious Diseases, 2024.  [Content Brief]