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LRRC52 Protein, Human (HEK293, His)

Cat. No.: HY-P77991
Handling Instructions

LRRC52 Protein, associated with the BK channel, crucially modulates its gating properties. It induces a significant hyperpolarizing shift in activation voltage, especially without calcium. As a KCNU1 auxiliary protein, LRRC52 may influence KCNU1 gating. LRRC52's interaction with KCNU1 is essential for stability, potentially altering channel gating. LRRC52 also interacts with KCNMA1, further indicating its role in regulating BK channel activity. LRRC52 Protein, Human (HEK293, His) is the recombinant human-derived LRRC52 protein, expressed by HEK293, with C-His labeled tag. The total length of LRRC52 Protein, Human (HEK293, His) is 221 a.a., with molecular weight of 35-48 kDa.

For research use only. We do not sell to patients.

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Description

LRRC52 Protein, associated with the BK channel, crucially modulates its gating properties. It induces a significant hyperpolarizing shift in activation voltage, especially without calcium. As a KCNU1 auxiliary protein, LRRC52 may influence KCNU1 gating. LRRC52's interaction with KCNU1 is essential for stability, potentially altering channel gating. LRRC52 also interacts with KCNMA1, further indicating its role in regulating BK channel activity. LRRC52 Protein, Human (HEK293, His) is the recombinant human-derived LRRC52 protein, expressed by HEK293, with C-His labeled tag. The total length of LRRC52 Protein, Human (HEK293, His) is 221 a.a., with molecular weight of 35-48 kDa.

Background

LRRC52, an auxiliary protein associated with the large-conductance, voltage, and calcium-activated potassium channel (BK alpha), plays a crucial role in modulating the gating properties of the BK channel. It induces a significant shift in the voltage dependence of activation in the hyperpolarizing direction, particularly in the absence of calcium. Functioning as a KCNU1 channel auxiliary protein, LRRC52 may also influence the gating properties of KCNU1. The interaction between LRRC52 and KCNU1 is proposed to be essential for LRRC52 stability and may contribute to alterations in channel gating properties. Additionally, LRRC52 interacts with KCNMA1, further implicating its involvement in the regulation of BK channel activity.

Species

Human

Source

HEK293

Tag

C-His

Accession

Q8N7C0 (S24-D244)

Gene ID

440699  [NCBI]

Molecular Construction
N-term
LRRC52 (S24-D244)
Accession # Q8N7C0
His
C-term
Synonyms
LRRC52; FLJ25811
Molecular Weight

35-48 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

LRRC52 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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LRRC52 Protein, Human (HEK293, His)
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HY-P77991
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