LRRC52 Protein, Human (HEK293, His)

LRRC52 Protein, associated with the BK channel, crucially modulates its gating properties. It induces a significant hyperpolarizing shift in activation voltage, especially without calcium. As a KCNU1 auxiliary protein, LRRC52 may influence KCNU1 gating. LRRC52's interaction with KCNU1 is essential for stability, potentially altering channel gating. LRRC52 also interacts with KCNMA1, further indicating its role in regulating BK channel activity. LRRC52 Protein, Human (HEK293, His) is the recombinant human-derived LRRC52 protein, expressed by HEK293, with C-His labeled tag. The total length of LRRC52 Protein, Human (HEK293, His) is 221 a.a., with molecular weight of 35-48 kDa.

LRRC52, an auxiliary protein associated with the large-conductance, voltage, and calcium-activated potassium channel (BK alpha), plays a crucial role in modulating the gating properties of the BK channel. It induces a significant shift in the voltage dependence of activation in the hyperpolarizing direction, particularly in the absence of calcium. Functioning as a KCNU1 channel auxiliary protein, LRRC52 may also influence the gating properties of KCNU1. The interaction between LRRC52 and KCNU1 is proposed to be essential for LRRC52 stability and may contribute to alterations in channel gating properties. Additionally, LRRC52 interacts with KCNMA1, further implicating its involvement in the regulation of BK channel activity.

Human

HEK293

C-His

Q8N7C0 (S24-D244)

440699  [NCBI]

35-48 kDa

Greater than 95% as determined by Tris-Bis PAGE.

<1 EU/μg, determined by LAL method.