SCYL2 Protein, Human (Sf9, His, GST)

The SCYL2 protein is a component of the AP2-containing clathrin coat and may regulate clathrin-dependent trafficking at the plasma membrane, TGN, and endosomal systems. SCYL2 Protein, Human (Sf9, His, GST) is the recombinant human-derived SCYL2 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of SCYL2 Protein, Human (Sf9, His, GST) is 928 a.a., .

SCYL2 is a key component of the AP2-containing clathrin coat, suggesting its potential role in the regulation of clathrin-dependent trafficking at the plasma membrane, trans-Golgi network (TGN), and endosomal system. While its proposed serine/threonine-protein kinase activity toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in the presence of poly-L-lysine awaits confirmation, SCYL2's interaction with clathrin and AP2B1 is established, mediating its association with the AP-2 complex. Beyond its role in intracellular trafficking, SCYL2 is implicated in the modulation of excitatory receptor expression at synapses, contributing significantly to neuronal function, signaling, and brain development. This multifaceted involvement underscores the importance of SCYL2 in diverse cellular processes with potential implications for neurological functions.

Human

Sf9 insect cells

N-8*His;N-GST

Q6P3W7 (E2-G929)

55681

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.