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Results for "

3D53

" in MedChemExpress (MCE) Product Catalog:

2

Inhibitors & Agonists

1

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-106178
    PMX-53
    4 Publications Verification

    3D53

    		 Complement System Cardiovascular Disease Inflammation/Immunology Cancer
    PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC50 of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects .
    PMX-53
  • HY-106178D
    PMX 53 monoacetate

    3D53 monoacetate

    		 Others Inflammation/Immunology
    PMX 53 monoacetate (3D53 monoacetate) is a potent orally active CD88 (C5aR) antagonist that inhibits C5a-induced neutrophil myeloperoxide release and chemotactic activity. PMX 53 monoacetate has an IC50 value of 20 nM against C5a-induced neutrophil myeloperoxide release. >The value is 22 nM, and the IC50 value of the chemotactic activity is 75 nM. PMX 53 monoacetate is also an agonist of MrgX2 .
    PMX 53 monoacetate

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