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Results for "

Angiopoietin-like protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ANGPTL (3)
By Research Areas:	Cardiovascular Disease (1) Metabolic Disease (3)
Oligonucleotides:	Antisense Oligonucleotides (2)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Oligonucleotides

Targets Recommended: ANGPTL Polo-like Kinase (PLK) NOD-like Receptor (NLR) Toll-like Receptor (TLR) Tie KLF PERK ULK METTL3 MASTL ADAMTS IGF-1R LOX-1 Nuclear Hormone Receptor 4A/NR4A FLT3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153497A

Vupanorsen sodium IONIS ANGPT-L3Rx sodium; ISIS 703802 sodium	ANGPTL	Metabolic Disease
Vupanorsen (sodium) is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen (sodium) lowers triglycerides and atherogenic lipoproteins.

HY-P99194

Evinacumab REGN1500	ANGPTL Others	Cardiovascular Disease Metabolic Disease
Evinacumab (REGN1500) is a human anti-ANGPTL3 (angiopoietin-like protein 3) monoclonal antibody (IgG4 class antibody). Evinacumab reduces plasma lipids in dyslipidemic mice by blocking ANGPTL3. Evinacumab can be used in studies of homozygous familial hypercholesterolaemia (HoFH), refractory hypercholesterolaemia (both familial and non-familial) and severe hypertriglyceridaemia .

HY-153497

Vupanorsen IONIS ANGPT-L3Rx; ISIS 703802	ANGPTL	Metabolic Disease
Vupanorsen is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen lowers triglycerides and atherogenic lipoproteins.

Cat. No.	Product Name	Target	Research Area

HY-P99194

Evinacumab REGN1500	ANGPTL Inhibitory Antibodies	Cardiovascular Disease Metabolic Disease
Evinacumab (REGN1500) is a human anti-ANGPTL3 (angiopoietin-like protein 3) monoclonal antibody (IgG4 class antibody). Evinacumab reduces plasma lipids in dyslipidemic mice by blocking ANGPTL3. Evinacumab can be used in studies of homozygous familial hypercholesterolaemia (HoFH), refractory hypercholesterolaemia (both familial and non-familial) and severe hypertriglyceridaemia .

Species:	Human (13) Rhesus Macaque (1) Mouse (5) Cynomolgus (3) Canine (3)
Tag:	His (18) SUMO (1) Avi (5) GST (2) Fc (5)
Source:	HEK293 (18) P. pastoris (1) Sf9 insect cells (3) E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P7504

	*ANGPTL3/Angiopoietin-like* 3 Protein, Mouse (HEK293, His)** rMuAngiopoietin-like protein 3, His; ANGPTL3; Angiopoietin-like protein 3	Mouse	HEK293
	ANGPTL3/Angiopoietin-like 3 Protein, Mouse (HEK293, His) is a mouse recombinant ANGPTL3 with a 10-His tag at the C-terminus. Angiopoietin-like Protein 3, Mouse (HEK293, His) is produced by Mammalian expression system and the target gene encoding Ser17-Thr455 is expressed.

HY-P7505

	*ANGPTL3/Angiopoietin-like* 3 Protein, Human (204a.a, HEK293, His)** rHuAngiopoietin-like protein 3, His; ANGPTL3; Angiopoietin-like protein 3	Human	HEK293
	ANGPTL3/Angiopoietin-like 3 Protein, Human (HEK293, His) plays an important role in lipoprotein metabolism.Angiopoietin-like Protein 3 acts as a dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL).Angiopoietin-like Protein 3 inhibits endothelial lipase hydrolysis of HDL-phospholipid (PL), thereby increasing HDL-PL levels.

HY-P7506

	*ANGPTL8/Angiopoietin-like* 8 Protein, Human (HEK293, Fc)** rHuAngiopoietin-like protein 8, N-Fc; ANGPTL8; Betatrophin; C19orf81; Angiopoietin-like protein 8	Human	HEK293
	ANGPTL 8 Protein, Human (HEK293, Fc) is a secreted inhibitor of LPL. Angiopoietin-like Protein 8 may function as an important metabolic switch, by forming complexes with ANGPTL3, or with ANGPTL4, in order to direct the flow of energy from triglycerides in blood according to the needs of the body.

HY-P700561

	*ANGPTL8/Angiopoietin-like* 8 Protein, Mouse (P. pastoris, His)** rHuAngiopoietin-like protein 8, N-Fc; ANGPTL8; Betatrophin; C19orf81; Angiopoietin-like protein 8	Mouse	P. pastoris
	ANGPTL8, a blood lipid regulator, controls serum triglyceride levels and orchestrates metabolic transitions during fasting and refeeding. Its role involves directing fatty acid storage in adipose tissue during the fed state. Though its precise mechanism is not fully understood, ANGPTL8 has been suggested to promote ANGPTL3 cleavage, interacting with ANGPTL3 for regulatory functions in lipid metabolism. ANGPTL8/Angiopoietin-like 8 Protein, Mouse (P. pastoris, His) is the recombinant mouse-derived ANGPTL8/Angiopoietin-like 8 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of ANGPTL8/Angiopoietin-like 8 Protein, Mouse (P. pastoris, His) is 183 a.a., with molecular weight of 22.5 kDa.

HY-P78059

	*ANGPTL3/Angiopoietin-like* 3 Protein, Human (Biotinylated, HEK293, His-Avi)** ANGPTL3; ANGPT5; ANG-5; Angiopoietin-5; FHBL2; ANL3; Angiopoietin-5; Angiopoietin-like protein 3	Human	HEK293
	ANGPTL3/angiopoietin-like 3 protein is a hepatic factor that complexly regulates lipid and glucose metabolism.It stimulates plasma triglycerides by inhibiting lipoprotein lipase (LPL), inhibits TG clearance through PCSK6 and FURIN recruitment, is independent of proteolytic cleavage, and is not affected by GPIHBP1.ANGPTL3/Angiopoietin-like 3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ANGPTL3/Angiopoietin-like 3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P700954

	*ANGPTL3/Angiopoietin-like* 3 Protein, Cynomolgus (HEK293, His)** ANGPTL3; ANGPT5; ANG-5; Angiopoietin-5; FHBL2; ANL3; Angiopoietin-5; Angiopoietin-like protein 3	Cynomolgus	HEK293
	ANGPTL3/angiopoietin-like 3 protein is a hepatic factor that complexly regulates lipid and glucose metabolism. It stimulates plasma triglycerides by inhibiting lipoprotein lipase (LPL), inhibits TG clearance through PCSK6 and FURIN recruitment, is independent of proteolytic cleavage, and is not affected by GPIHBP1. ANGPTL3/Angiopoietin-like 3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived ANGPTL3/Angiopoietin-like 3 protein, expressed by HEK293 , with C-His labeled tag. The total length of ANGPTL3/Angiopoietin-like 3 Protein, Cynomolgus (HEK293, His) is 444 a.a., with molecular weight of 60-70 kDa.

HY-P71652

	*ANGPTL2/Angiopoietin-like* 2 Protein, Human (His-SUMO)** Angiopoietin like 2; Angiopoietin related protein 2 ; Angiopoietin-like protein 2; Angiopoietin-related protein 2; HARP; MGC8889; UNQ170/PRO196	Human	E. coli
	ANGPTL2/angiopoietin-like 2 protein takes center stage as it induces endothelial cell sprouting through dual autocrine and paracrine mechanisms.This ability underscores its critical role in angiogenesis, where balanced signaling events control the formation of new blood vessels.ANGPTL2/Angiopoietin-like 2 Protein, Human (His-SUMO) is the recombinant human-derived ANGPTL2/Angiopoietin-like 2 protein, expressed by E.coli , with N-His, N-SUMO labeled tag.

HY-P78379

	*ANGPTL3/Angiopoietin-like* 3 Protein, Human (HEK293, His-Avi)** ANGPTL3; ANGPT5; ANG-5; Angiopoietin-5; FHBL2; ANL3; Angiopoietin-5; Angiopoietin-like protein 3	Human	HEK293
	ANGPTL3/angiopoietin-like 3 protein is a hepatic factor that complexly regulates lipid and glucose metabolism.It stimulates plasma triglycerides by inhibiting lipoprotein lipase (LPL), inhibits TG clearance through PCSK6 and FURIN recruitment, is independent of proteolytic cleavage, and is not affected by GPIHBP1.ANGPTL3/Angiopoietin-like 3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived ANGPTL3/Angiopoietin-like 3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P700562

	*ANGPTL4/Angiopoietin-related 4 Protein, Human (GST)* Angiopoietin-like protein 4Hepatic fibrinogen/Angiopoietin-related protein ; HFARP	Human	E. coli
	ANGPTL4 protein mediates lipoprotein lipase (LPL) inactivation, regulating triglyceride clearance and lipid metabolism. It also affects glucose homeostasis, insulin sensitivity, endothelial cell function, and angiogenesis. Cleaved ANGPTL4 is more active in LPL inactivation, highlighting its multifaceted role in metabolic and vascular regulation. ANGPTL4/Angiopoietin-related 4 Protein, Human (GST) is the recombinant human-derived ANGPTL4/Angiopoietin-related 4 protein, expressed by E. coli , with N-GST labeled tag.

HY-P700633

	*ANGPTL8/Angiopoietin-like* 8 Protein, Mouse (H40A, Q44A, Q47A, His)** rHuAngiopoietin-like protein 8, N-Fc; ANGPTL8; Betatrophin; C19orf81; Angiopoietin-like protein 8	Mouse	E. coli
	ANGPTL8, a blood lipid regulator, controls serum triglyceride levels and orchestrates metabolic transitions during fasting and refeeding. Its role involves directing fatty acid storage in adipose tissue during the fed state. Though its precise mechanism is not fully understood, ANGPTL8 has been suggested to promote ANGPTL3 cleavage, interacting with ANGPTL3 for regulatory functions in lipid metabolism. ANGPTL8/Angiopoietin-like 8 Protein, Mouse (H40A, Q44A, Q47A, His) is the recombinant mouse-derived ANGPTL8/Angiopoietin-like 8 protein, expressed by E. coli , with C-6*His labeled tag and H40A, Q44A, Q47A inactivating mutations. The total length of ANGPTL8/Angiopoietin-like 8 Protein, Mouse (H40A, Q44A, Q47A, His) is 183 a.a., with molecular weight of 21.3 kDa.

HY-P700852

	*ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, hFc)* Angiopoietin-like 7; Angiopoietin-like factor; ANGPTL7; AngX; CDT6	Human	HEK293
	ANGPTL7/angiopoietin-related 7 protein plays a crucial role in the formation and organization of the extracellular matrix. Particularly in the eye, it serves as a mediator for dexamethasone-induced matrix deposition within the trabecular meshwork, a tissue that studies have shown is necessary for aqueous humor outflow and maintenance of intraocular pressure. ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, hFc) is the recombinant human-derived ANGPTL7/Angiopoietin-related 7 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, hFc) is 320 a.a., with molecular weight of 70-90 kDa.

HY-P700955

	*ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, His-Avi)* Angiopoietin-like 7; Angiopoietin-like factor; ANGPTL7; AngX; CDT6	Human	HEK293
	ANGPTL7/angiopoietin-related 7 protein plays a crucial role in the formation and organization of the extracellular matrix. Particularly in the eye, it serves as a mediator for dexamethasone-induced matrix deposition within the trabecular meshwork, a tissue that studies have shown is necessary for aqueous humor outflow and maintenance of intraocular pressure. ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, His-Avi) is the recombinant human-derived ANGPTL7/Angiopoietin-related 7 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of ANGPTL7/Angiopoietin-related 7 Protein, Human (HEK293, His-Avi) is 320 a.a., with molecular weight of 35-40 kDa.

HY-P78380

	*ANGPTL2/Angiopoietin-like* 2 Protein, Human (HEK293, His-Avi)** ARP2; HARP; Angiopoietin-like 2; ANGPTL2; ANGRP2; MGC8889	Human	HEK293
	ANGPTL2/angiopoietin-like 2 protein takes center stage as it induces endothelial cell sprouting through dual autocrine and paracrine mechanisms.This ability underscores its critical role in angiogenesis, where balanced signaling events control the formation of new blood vessels.ANGPTL2/Angiopoietin-like 2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived ANGPTL2/Angiopoietin-like 2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78060

	*ANGPTL2/Angiopoietin-like* 2 Protein, Human (Biotinylated, HEK293, His-Avi)** ARP2; HARP; Angiopoietin-like 2; ANGPTL2; ANGRP2; MGC8889	Human	HEK293
	ANGPTL2/angiopoietin-like 2 protein takes center stage as it induces endothelial cell sprouting through dual autocrine and paracrine mechanisms.This ability underscores its critical role in angiogenesis, where balanced signaling events control the formation of new blood vessels.ANGPTL2/Angiopoietin-like 2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ANGPTL2/Angiopoietin-like 2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P75507

	*ANGPTL7/Angiopoietin-related 7 Protein, Canine (HEK293, His)* Angiopoietin-like factor; ANGPTL7; AngX; CDT6	Canine	HEK293
	ANGPTL7/ Angiopoietin-related proteins are negative regulators of corneal angiogenesis and play an important role in maintaining the patency and transparency of corneal blood vessels. ANGPTL7 is regulated by SP1 transcription and regulates ANGPTL7 levels through the RhoA/ROCK signaling pathway mediating CLAN formation. ANGPTL7/Angiopoietin-related 7 Protein, Canine (HEK293, His) is the recombinant canine-derived ANGPTL7/Angiopoietin-related 7 protein, expressed by HEK293 , with C-His labeled tag.

HY-P75508

	*ANGPTL7/Angiopoietin-related 7 Protein, Canine (HEK293, Fc)* Angiopoietin-like factor; ANGPTL7; AngX; CDT6	Canine	HEK293
	ANGPTL7/ Angiopoietin-related proteins are negative regulators of corneal angiogenesis and play an important role in maintaining the patency and transparency of corneal blood vessels. ANGPTL7 is regulated by SP1 transcription and regulates ANGPTL7 levels through the RhoA/ROCK signaling pathway mediating CLAN formation. ANGPTL7/Angiopoietin-related 7 Protein, Canine (HEK293, Fc) is the recombinant canine-derived ANGPTL7/Angiopoietin-related 7 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76727

	*ANGPTL5/Angiopoietin-like* 5 Protein, Human (sf9, GST)** Angiopoietin-related protein 5; ANGPTL5	Human	Sf9 insect cells
	ANGPTL5/Angiopoietin-like 5 Protein, a member of angiopoietin-like proteins (ANGPTLs) family, is mainly expressed in adult human heart. It plays a functional role in the expansion of human cord blood hematopoietic stem cells. In addition, ANGPTL5 is an adipocytokine and has an important role in metabolic processes including lipid metabolism, obesity, and type 2 diabetes mellitus. ANGPTL5/Angiopoietin-like 5 Protein, Human (sf9, GST) is the recombinant human-derived ANGPTL5/Angiopoietin-like 5 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of ANGPTL5/Angiopoietin-like 5 Protein, Human (sf9, GST) is 363 a.a., with molecular weight of ~68 kDa.

HY-P76726

	*ANGPTL3/Angiopoietin-like* 3 Protein, Cynomolgus (sf9, His)** Angiopoietin-related protein 3; Angiopoietin-5; ANG-5; ANGPT5	Cynomolgus	Sf9 insect cells
	ANGPTL3/Angiopoietin-like 3 is a vascular growth factor and a member of the angiopoietin like protein family. It has high specificity for endothelial cells, performs various other regulatory activities to affect inflammation, and has been proved to have atherosclerosis promoting and atherosclerosis protective effects. NGPTL3/Angiopoietin-like 3 can also inhibit the activity of lipoprotein lipase and induce angiogenesis. ANGPTL3/Angiopoietin-like 3 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived ANGPTL3/Angiopoietin-like 3 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P75577

	*ANGPTL2/Angiopoietin-like* 2 Protein, Human (HEK293, His)** Angiopoietin-related protein 2; ANGPTL2; ANGRP2; ARP2HARP; MGC8889	Human	HEK293
	ANGPTL2/angiopoietin-like 2 protein takes center stage as it induces endothelial cell sprouting through dual autocrine and paracrine mechanisms. This ability underscores its critical role in angiogenesis, where balanced signaling events control the formation of new blood vessels. ANGPTL2/Angiopoietin-like 2 Protein, Human (HEK293, His) is the recombinant human-derived ANGPTL2/Angiopoietin-like 2 protein, expressed by HEK293 , with N-His labeled tag.

HY-P75578

	*ANGPTL2/Angiopoietin-like* 2 Protein, Mouse (HEK293, Fc)** Angiopoietin-related protein 2; ANGPTL2; ANGRP2; ARP2HARP; MGC8889	Mouse	HEK293
	ANGPTL2/Angiopoietin-like 2 protein plays a crucial role in inducing sprouting in endothelial cells through autocrine and paracrine mechanisms.It orchestrates angiogenic processes and regulates vascular development.ANGPTL2's versatile impact on endothelial cell behavior positions it as a key modulator in the molecular signals governing angiogenesis.ANGPTL2/Angiopoietin-like 2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived ANGPTL2/Angiopoietin-like 2 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P75580

	*ANGPTL3/Angiopoietin-like* 3 Protein, Human (sf9, His)** Angiopoietin-5; ANG-5; ANGPTL3; ANGPT5; UNQ153/PRO179	Human	Sf9 insect cells
	ANGPTL3/angiopoietin-like 3 protein is a hepatic factor that complexly regulates lipid and glucose metabolism.It stimulates plasma triglycerides by inhibiting lipoprotein lipase (LPL), inhibits TG clearance through PCSK6 and FURIN recruitment, is independent of proteolytic cleavage, and is not affected by GPIHBP1.ANGPTL3/Angiopoietin-like 3 Protein, Human (sf9, His) is the recombinant human-derived ANGPTL3/Angiopoietin-like 3 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P77295

	ANGPTL1 Protein, Canine (HEK293, Fc) Angiopoietin like 1; ANGPTL1; ANG-3	Canine	HEK293

HY-P75506

	*ANGPTL7/Angiopoietin-related 7 Protein, Rhesus Macaque (HEK293, His)* Angiopoietin like 7; ANGPTL7; CDT6	Rhesus Macaque	HEK293
	ANGPTL7/angiopoietin-related 7 protein plays a crucial role in the formation and organization of the extracellular matrix. Particularly in the eye, it serves as a mediator for dexamethasone-induced matrix deposition within the trabecular meshwork, a tissue that studies have shown is necessary for aqueous humor outflow and maintenance of intraocular pressure. ANGPTL7/Angiopoietin-related 7 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived ANGPTL7/Angiopoietin-related 7 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700655

	*ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His)* ANGPTL4; ARP4; FIAF; HFARP; Angiopoietin like 4; NGPTL2; NL2; PGAR; pp1158; ANG-3; ANG4; AGP4; ANG3; ANG-3; ANG-4	Cynomolgus	HEK293
	ANGPTL4/angiopoietin-related 4 protein plays a key role in regulating lipid metabolism by inactivating lipoprotein lipase (LPL) and controlling the clearance of triglycerides in the blood. Its effects extend to the regulation of glucose homeostasis and insulin sensitivity. ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived ANGPTL4/Angiopoietin-related 4 protein, expressed by HEK293 , with N-His labeled tag. The total length of ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His) is 243 a.a., with molecular weight of 35-40 kDa.

HY-P78237

	*ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His)* ANGPTL4; ARP4; FIAF; HFARP; Angiopoietin like 4; NGPTL2; NL2; PGAR; pp1158; ANG-3; ANG4; AGP4; ANG3; ANG-3; ANG-4; Angiopoietin-3; ANGPT4; MGC138181; MGC138183	Mouse	HEK293
	ANGPTL4/angiopoietin-related 4 protein plays a key role in regulating lipid metabolism by inactivating lipoprotein lipase (LPL) and controlling the clearance of triglycerides in the blood. Its effects extend to the regulation of glucose homeostasis and insulin sensitivity. ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ANGPTL4/Angiopoietin-related 4 protein, expressed by HEK293 , with N-His labeled tag. The total length of ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His) is 243 a.a., with molecular weight of 35-50 kDa.

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HY-153497A

Vupanorsen sodium IONIS ANGPT-L3Rx sodium; ISIS 703802 sodium		Antisense Oligonucleotides
Vupanorsen (sodium) is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen (sodium) lowers triglycerides and atherogenic lipoproteins.

HY-153497

Vupanorsen IONIS ANGPT-L3Rx; ISIS 703802		Antisense Oligonucleotides
Vupanorsen is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen lowers triglycerides and atherogenic lipoproteins.

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