Vupanorsen (Synonyms: IONIS ANGPT-L3Rx; ISIS 703802)

Cat. No.: HY-153497: FAQs
Data Sheet SDS COA Handling Instructions

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Vupanorsen is an N-acetyl galactosamine-conjugated antisense oligonucleotide that inhibits Angiopoietin-like 3 (ANGPTL3) protein synthesis. Vupanorsen lowers triglycerides and atherogenic lipoproteins.

The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Vupanorsen sodium) that retains the same biological activity.

For research use only. We do not sell to patients.

DNA, d([2′-O-(2-methoxyethyl)]rG-sp-[2′-O-(2-methoxyethyl)]rG-[2′-O-(2-methoxyethyl)]rA-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]rA-T-sp-T-sp-G-sp-m5C-sp-m5C-sp-A-sp-G-sp-T-sp-A-sp-A-sp-[2′-O-(2-methoxyethyl)]m5rU-[2′-O-(2-methoxyethyl)]m5rC-[2′-O-(2-methoxyethyl)]rG-sp-[2′-O-(2-methoxyethyl)]m5rC-sp-[2′-O-(2-methoxyethyl)]rA), 5′-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate]

Vupanorsen Chemical Structure

CAS No. : 2097587-62-5

Size	Price	Stock
1 mg	USD 294	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

Other Forms of Vupanorsen:

Vupanorsen sodium Get quote
Vupanorsen triethylamine Get quote

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ANGPTL3

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

ANGPTL3

Clinical Trial

CAS No.

2097587-62-5

Appearance

Solid

Color

White to off-white

SMILES

[Vupanorsen]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 92.29%

Select Batch:

Data Sheet (266 KB) SDS (252 KB)

COA (248 KB) LCMS (322 KB)

Handling Instructions (2659 KB)

References

[1]. Bergmark BA, Marston NA, Bramson CR, et al. Effect of Vupanorsen on Non-High-Density Lipoprotein Cholesterol Levels in Statin-Treated Patients With Elevated Cholesterol: TRANSLATE-TIMI 70. Circulation. 2022;145(18):1377-1386. [Content Brief]

[2]. Gaudet D, Karwatowska-Prokopczuk E, Baum SJ, et al. Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia. Eur Heart J. 2020;41(40):3936-3945. [Content Brief]

Vupanorsen Related Classifications

Metabolic Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vupanorsen2097587-62-5IONIS ANGPT-L3Rx ISIS 703802ISIS703802ISIS 703802ISIS-703802ANGPTLAngiopoietin-like proteinInhibitorinhibitorinhibit

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