ANGPTL3/Angiopoietin-like 3 Protein, Cynomolgus (sf9, His)

ANGPTL3/Angiopoietin-like 3 is a vascular growth factor and a member of the angiopoietin like protein family. It has high specificity for endothelial cells, performs various other regulatory activities to affect inflammation, and has been proved to have atherosclerosis promoting and atherosclerosis protective effects. NGPTL3/Angiopoietin-like 3 can also inhibit the activity of lipoprotein lipase and induce angiogenesis. ANGPTL3/Angiopoietin-like 3 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived ANGPTL3/Angiopoietin-like 3 protein, expressed by Sf9 insect cells , with C-His labeled tag.

ANGPTL3/Angiopoietin-like 3 is a vascular growth factor, which is highly specific to endothelial cells, performs various other regulatory activities to affect inflammation, and has been proved to have atherosclerosis promoting and atherosclerosis protecting effects^[1].
ANGPTL3/Angiopoietin-like 3 can inhibit the activity of lipoprotein lipase in vitro and in vivo, and plays a crucial role in human lipoprotein metabolism. In addition, ANGPTL3/Angiopoietin-like 3 can stimulate the adhesion and migration of endothelial cells and induce angiogenesis by binding to the cell integrin αVβ3. ANGPTL3/Angiopoietin-like 3 also activates protein kinase B and increases the permeability of glomerular endothelial cells ^[2].
The loss of function, inactivation or down-regulation of ANGPTL3/Angiopoietin-like 3 is related to the significant reduction of plasma TGs, LDL-C and high-density lipoprotein cholesterol (HDL-C) levels, atherosclerosis and the risk of cardiovascular events^[3].

Cynomolgus

Sf9 insect cells

C-His

A0A2K5UDC5/XP_005543242 (S17-P220)

102136264  [NCBI]

Approximately 25.2 kDa.

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.