ANGPTL8/Angiopoietin-like 8 Protein, Mouse (P. pastoris, His)

ANGPTL8, a blood lipid regulator, controls serum triglyceride levels and orchestrates metabolic transitions during fasting and refeeding. Its role involves directing fatty acid storage in adipose tissue during the fed state. Though its precise mechanism is not fully understood, ANGPTL8 has been suggested to promote ANGPTL3 cleavage, interacting with ANGPTL3 for regulatory functions in lipid metabolism. ANGPTL8/Angiopoietin-like 8 Protein, Mouse (P. pastoris, His) is the recombinant mouse-derived ANGPTL8/Angiopoietin-like 8 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of ANGPTL8/Angiopoietin-like 8 Protein, Mouse (P. pastoris, His) is 183 a.a., with molecular weight of 22.5 kDa.

ANGPTL8, known as a blood lipid regulator, plays a pivotal role in controlling serum triglyceride levels. This hormone is implicated in orchestrating the metabolic transition between fasting and refeeding, facilitating the directed storage of fatty acids in adipose tissue during the fed state. While its precise mechanism is not fully elucidated, ANGPTL8 has been suggested to promote ANGPTL3 cleavage according to one report, although another study contradicts this claim by stating that ANGPTL8 is not required for ANGPTL3 cleavage. Notably, ANGPTL8 engages in interactions with ANGPTL3, further contributing to its regulatory functions in lipid metabolism.

Mouse

P. pastoris

N-6*His

Q8R1L8 (V16-A198)

624219  [NCBI]

VRPAPVAPLGGPEPAQYEELTLLFHGALQLGQALNGVYRATEARLTEAGHSLGLYDRALEFLGTEVRQGQDATQELRTSLSEIQVEEDALHLRAEATARSLGEVARAQQALRDTVRRLQVQLRGAWLGQAHQEFETLKARADKQSHLLWALTGHVQRQQREMAEQQQWLRQIQQRLHTAALPA

27 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.