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Aristolochic acid A (Standard)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Caspase (1) NF-κB (1) Phospholipase (1)
By Research Areas:	Cancer (4) Inflammation/Immunology (1)

5

Inhibitors & Agonists

5

Natural
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Targets Recommended: Amino acid Transporter Amino Acid Derivatives Hydroxycarboxylic Acid Receptor (HCAR) Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Aristolochic acid A (Standard)	NF-κB	Cancer
Aristolochic acid A (Standard) is the analytical standard of Aristolochic acid A. This product is intended for research and analytical applications. Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines .

Aristolochic acid D (Standard)	Others	Cancer
Aristolochic acid D (Standard) is the analytical standard of Aristolochic acid D. This product is intended for research and analytical applications. Aristolochic acid D is an aristolochic acid derivative isolated from stems of Aristolochia indica. Aristolochic acid is nephrotoxin and carcinogen .

Aristolochic acid B (Standard)	Others	Cancer
Aristolochic acid B (Standard) is the analytical standard of Aristolochic acid B. This product is intended for research and analytical applications. Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo .

Aristolochic acid C (Standard)	Phospholipase	Cancer
Aristolochic acid C (Standard) is the analytical standard of Aristolochic acid C. This product is intended for research and analytical applications. Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A2 (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis .

Aristolactam I (Standard)	Caspase Apoptosis	Inflammation/Immunology
Aristolactam I (Standard) is the analytical standard of Aristolactam I. This product is intended for research and analytical applications. Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage. Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway .

Cat. No.	Product Name	Category	Target	Chemical Structure

Aristolochic acid A (Standard)	Alkaloids Structural Classification other families Aristolochia debilis Sieb. et Zucc. Other Alkaloids Source classification Plants Aristolochiaceae	NF-κB
Aristolochic acid A (Standard) is the analytical standard of Aristolochic acid A. This product is intended for research and analytical applications. Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines .

Aristolochic acid D (Standard)	Structural Classification Monophenols other families Ketones, Aldehydes, Acids Source classification Phenols Plants	Others
Aristolochic acid D (Standard) is the analytical standard of Aristolochic acid D. This product is intended for research and analytical applications. Aristolochic acid D is an aristolochic acid derivative isolated from stems of Aristolochia indica. Aristolochic acid is nephrotoxin and carcinogen .

Aristolochic acid B (Standard)	Structural Classification Natural Products other families Source classification Plants	Others
Aristolochic acid B (Standard) is the analytical standard of Aristolochic acid B. This product is intended for research and analytical applications. Aristolochic acid B is one of the major components of Aristolochic acids (AA) which are natural products derived from taxa in the Aristolochiaceae. Aristolochic acid is known to be a potent mutagen and carcinogen. Aristolochic acid B showes more carcinogenic risk than Aristolochic acid A in vivo .

Aristolochic acid C (Standard)	Structural Classification Monophenols other families Source classification Phenols Plants	Phospholipase
Aristolochic acid C (Standard) is the analytical standard of Aristolochic acid C. This product is intended for research and analytical applications. Aristolochic acid C is a derivative of Aristolochic acid. Aristolochic acid is a phospholipase A2 (PLA2) inhibitor, which disrupts cortical microtubule arrays and root growth in Arabidopsis .

Aristolactam I (Standard)	Structural Classification Natural Products other families Source classification Plants	Caspase Apoptosis
Aristolactam I (Standard) is the analytical standard of Aristolactam I. This product is intended for research and analytical applications. Aristololactam I (AL-I), is the main metabolite of aristolochic acid I (AA-I), participates in the processes that lead to renal damage. Aristololactam I (AL-I) directly injures renal proximal tubule cells, the cytotoxic potency of AL-I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase-3-dependent pathway .

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