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DHA

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B2167
    Docosahexaenoic acid
    Maximum Cited Publications
    26 Publications Verification

    DHA; Cervonic acid

    		 Endogenous Metabolite Neurological Disease Cancer
    Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.
    Docosahexaenoic acid
  • HY-131397
    Docosahexaenoyl serotonin

    DHA-5-HT

    		 Interleukin Related Inflammation/Immunology
    Docosahexaenoyl serotonin (DHA-5-HT) is an endogenous n-3 fatty acid-serotonin conjugate. Docosahexaenoyl serotonin is an inhibitor of IL-17. Docosahexaenoyl serotonin has anti-inflammatory activity .
    Docosahexaenoyl serotonin
  • HY-165781
    DHA Ceramide

    C22:6 Ceramide

    		 Others Metabolic Disease
    DHA Ceramide (C22:6 Ceramide) is an ester product.
    DHA Ceramide
  • HY-B2167S
    Docosahexaenoic acid-d5

    DHA-d5; Cervonic acid-d5

    		 Endogenous Metabolite Neurological Disease
    Docosahexaenoic acid-d5 is the deuterium labeled Docosahexaenoic Acid. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk.
    Docosahexaenoic acid-d5
  • HY-W348896
    Fmoc-Dha-OH

    		Others Others
    Fmoc-Dha-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Fmoc-Dha-OH
  • HY-W440983
    SDPC

    PC(18:0/22:6); DHA-PC; 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine

    		 PPAR Cardiovascular Disease Cancer
    SDPC (DHA-PC) is a new generation of omega-3 lipids, which contains an ester bond linking DHA at the sn-2 position of phospholipid. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine exerts anti-angiogenesis effect through activating PPARγ. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine significantly declines the proliferation, migration, tube formation of human umbilical vein endothelial cells. 1-Stearoyl-2-docosahexaenoyl-sn-glyerco-3-phosphocholine has the potential for anti-tumor angiogenesis research .
    SDPC
  • HY-139408
    17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid

    17-Oxo-DHA; 17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-DHA

    		 PPAR Keap1-Nrf2 Metabolic Disease
    17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid (17-Oxo-DHA) is a metabolite of lipoxygenase-mediated oxidation of DHA. 17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid is a PPARγ agonist and activates a Nrf2 dependent antioxidant reaction .
    17-Oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-docosahexaenoic acid
  • HY-139247
    pNPS-DHA

    		Others Inflammation/Immunology
    pNPS-DHA (Compound 19) is an orally active DHA-ethanolamide (DHEA) derivative that has antiallergic activity. pNPS-DHA inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) reaction in mice. pNPS-DHA has anti-degranulating activity in RBL-2H3 mast cells with an IC50 of 15 μM .
    pNPS-DHA
  • HY-156559
    GlcNAc-SH

    		Biochemical Assay Reagents Others
    GlcNAc-SH is a thiol-derivatized saccharide that can be used to label Dha to generate glycoprotein mimics .
    GlcNAc-SH
  • HY-148944
    Didocosahexaenoin

    		Reactive Oxygen Species Apoptosis Cancer
    Didocosahexaenoin, an omega-3 derivative, is a diglyceride of DHA and can be synthesised from DHA triglycerides. Didocosahexaenoin causes significant loss of mitochondrial membrane potential and induces ROS production. Didocosahexaenoin induces apoptosis. Didocosahexaenoin induces stronger cytotoxicity than DHA in human prostate carcinoma cells .
    Didocosahexaenoin
  • HY-124019
    4,5-DiHDPA lactone

    		PPAR Neurological Disease
    4,5-DiHDPA lactone (5), a derivative of docosahexaenoic acid (DHA), is a PPARγ activator .
    4,5-DiHDPA lactone
  • HY-130550
    (±)7(8)-EpDPA

    		Endogenous Metabolite Others
    (±)7(8)-EpDPA is an epoxide derivative of docosahexaenoic acid (DHA) metabolized by CYP450 .
    (±)7(8)-EpDPA
  • HY-113777
    22-HDHA

    22-Hydroxy Docosahexaenoic acid; 22-OH DHA

    		 Others Metabolic Disease
    22-HDHA is an oxidation product of docosahexaenoic acid.1 In vitro, it is formed upon incubation of rat liver microsomes with DHA and NADPH and also by the human cytochrome P450 (CYP) isoform CYP4F3B in BTI-TN-5B1-4 microsomes. Serum levels of 22-HDHA increase following dietary DHA supplementation in humans.
    22-HDHA
  • HY-134997
    4-Oxo Docosahexaenoic Acid

    4-oxo DHA

    		 Others Cancer
    4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of Docosahexaenoic acid (HY-B2167) with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 μM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 μM.
    4-Oxo Docosahexaenoic Acid
  • HY-19886
    F 16915

    		Others Cardiovascular Disease
    F 16915, a Docosahexaenoic Acid (DHA, HY-B2167) derivative, is a potent pro-agent of DHA. F 16915 can prevent heart failure-induced atrial fibrillation .
    F 16915
  • HY-N11286
    Tridocosahexaenoylglycerol

    TG-DHA; Meganol D

    		 Others Neurological Disease Metabolic Disease Inflammation/Immunology
    Tridocosahexaenoylglycerol (TG-DHA) is an orally active dietary supplement that improves autoimmune encephalomyelitis in mice. Tridocosahexaenoylglycerol shows beneficial effects on neurodegenerative diseases and also improves macular function in diabetic retinopathy. Tridocosahexaenoylglycerol can be used for research on neurological diseases, inflammatory immune diseases, and metabolic diseases .
    Tridocosahexaenoylglycerol
  • HY-119684
    Maresin 2

    		Others Inflammation/Immunology
    Maresin 2 is an anti-inflammatory and pro-resolving mediator from human macrophages. Maresins are a new family of anti-inflammatory and pro-resolving lipid mediators biosynthesized from docosahexaenoic acid (DHA) by macrophages .
    Maresin 2
  • HY-136540
    Resolvin D3

    RvD3

    		 Others Inflammation/Immunology
    Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation .
    Resolvin D3
  • HY-116429A
    7(S)-Maresin 1

    		Reactive Oxygen Species Inflammation/Immunology
    7(S)-Maresin 1 is an inactive 7(S) exomer of Maresin 1, containing a 7(R) hydroxyl group. It can be used as a negative control. Maresin 1 is a specific regulator of endogenous DHA production in the human body, which can stimulate the production and secretion of intracellular Ca 2+ .
    7(S)-Maresin 1
  • HY-116663
    (±)20-HDHA

    (±)20-HDoHE

    		 Endogenous Metabolite Neurological Disease
    (±)20-HDHA ((±)20-HDoHE) is a racemic mixture and is an autoxidation product of Docosahexaenoic acid (DHA). (±)20-HDHA is also formed by peroxidation process in human platelets and rat brain homogenate .
    (±)20-HDHA
  • HY-113512
    17-HDHA

    		Others Inflammation/Immunology
    17-HDHA is a DHA-derived specialized proresolving mediator (SPM). 17-HDHA enhances the antibody-mediated immune response against influenza virus. 17-HDHA enhances the differentiation of B cells toward the CD27 + CD38 + antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells .
    17-HDHA
  • HY-130238
    (±)8-HDHA

    (±)8-HDoHE; 8-hydroxy Docosahexaenoic acid; (±)8-HDoHE

    		 Endogenous Metabolite Metabolic Disease
    (±)8-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)8-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
    (±)8-HDHA
  • HY-130287
    (±)16-HDHA

    (±)16-HDoHE; 16-hydroxy Docosahexaenoic acid; (±)16-HDoHE

    		 Endogenous Metabolite Metabolic Disease
    (±)16-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. (±)16-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
    (±)16-HDHA
  • HY-130288
    (±)13-HDHA

    (±)13-HDoHE; 13-hydroxy Docosahexaenoic acid; (±)13-HDoHE

    		 Others Inflammation/Immunology
    (±)13-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra is shown to metabolize DHA to 13(R)-HDHA, presumably via the 11R-lipoxygenase activity. (±)13-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
    (±)13-HDHA
  • HY-165071
    (±)16(17)-EpDPA

    (±)16,17 EDP; (±)16,17-Epoxy docosapentaenoic acid; (±)16,17-Epoxy DPA

    		 Others Others
    (±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA.
    (±)16(17)-EpDPA
  • HY-B2167R
    Docosahexaenoic acid (Standard)

    		Endogenous Metabolite Neurological Disease Cancer
    Docosahexaenoic acid (Standard) is the analytical standard of Docosahexaenoic acid. This product is intended for research and analytical applications. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid abundantly present brain and retina. It can be obtained directly from fish oil and maternal milk. In Vitro: Docosahexaenoic acid (DHA) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. The inclusion of plentiful DHA in the diet improves learning ability and memory . DHA is an essential requirement in every step of brain development like neural cell proliferation, migration, differentiation, synaptogenesis. The multiple double bonds and unique structure allow DHA to impart special membrane characteristics for effective cell signaling. Many development disorders like dyslexia, autism spectrum disorder, attention deficit hyperactivity disorder, schizophrenia etc. are causally related to decreased level of DHA . DHA is a potent RXR ligand inducing robust RXR activation already at low micro molar concentrations. The EC50 for RXRα activation by DHA is about 5-10 μM fatty acid . In Vivo: Docosahexaenoic acid administration over 10 weeks significantly reduces the number of reference memory errors, without affecting the number of working memory errors, and significantly increases the docosahexaenoic acid content and the docosahexaenoic acid/arachidonic acid ratio in both the hippocampus and the cerebral cortex . DHA treatment exerts neuroprotective actions on an experimental mouse model of PD. There is a decrease tendency in brain lipid oxidation of MPTP mice but it does not significantly .
    Docosahexaenoic acid (Standard)
  • HY-130419
    (±)13(14)-EpDPA

    13,14-EpDPE

    		 Others Cardiovascular Disease Neurological Disease
    (±)13(14)-EpDPA (13,14-EpDPE) is the product of the reaction of cytochrome P-450 epoxygenase with Docosahexaenoic Acid (DHA).(±)13(14)-EpDPA has antihyperalgesic and vasorelaxative activities .
    (±)13(14)-EpDPA
  • HY-139391
    (±)10(11)-DiHDPA

    		Others Others
    (±)10(11)-DiHDPA is a fatty acid diol and a metabolite of epoxidized fatty acids (EpFAs) .
    (±)10(11)-DiHDPA
  • HY-101540
    NMI 8739

    		Dopamine Receptor Neurological Disease
    NMI 8739 is a dopamine D2 autoreceptor agonist, which is an amine conjugate of the DHA carrier and the neurotransmitter dopamine.
    NMI 8739
  • HY-101541
    Docosahexaenoic acid methyl ester

    Methyl docosahexaenoate; all cis-DHA methyl ester

    		 Others Neurological Disease
    Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.
    Docosahexaenoic acid methyl ester
  • HY-120312
    PCTR3

    		Others Others
    PCTR3 is a Docosahexaenoic acid DHA (HY-B2167) derivative, which acts as a pro-resolving and tissue regeneration lipid mediator .
    PCTR3
  • HY-124355
    4-Hydroxy hexenal

    4-HHE

    		 Endogenous Metabolite Metabolic Disease
    4-Hydroxy hexenal (4-HHE) is a lipid peroxidation product derived from oxidized ω-3 fatty acids such as DHA.
    4-Hydroxy hexenal
  • HY-158623
    (±)13(14)-DiHDPA

    (±)13,14-DiHDPE

    		 Drug Metabolite Inflammation/Immunology
    (±)13(14)-DiHDPA ((±)13,14-DiHDPE) a metabolite of Docosahexaenoic acid (DHA; HY-B2167) by P450 (CYP) metabolic pathways .
    (±)13(14)-DiHDPA
  • HY-130239
    14(S)-HDHA

    14(S)-HDoHE

    		 Drug Metabolite Neurological Disease
    14(S)-HDHA (14(S)-HDoHE) is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway .
    14(S)-HDHA
  • HY-116429
    Maresin 1
    2 Publications Verification

    		 Reactive Oxygen Species Inflammation/Immunology
    Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca 2+] and secretion. Maresin 1 possesses anti-inflammatory activity .
    Maresin 1
  • HY-130289
    (±)4-HDHA

    4-Hydroxy docosahexaenoic acid; (±)4-HDoHE

    		 PPAR Metabolic Disease Inflammation/Immunology
    (±)4-HDHA (4-Hydroxy docosahexaenoic acid) is an autoxidation product of Docosahexaenoic acid (HY-B2167) (DHA). (±)4-HDHA is a PPARγ agonist, antidiabetic and anti-inflammatory agent .
    (±)4-HDHA
  • HY-W011120
    Ethyl docosa-4,7,10,13,16,19-hexaenoate
    1 Publications Verification

    		 Others Metabolic Disease
    Ethyl cis-4,7,10,13,16,19-Docosahexaenoate, the ethyl ester of Docosahexaenoate (DHA), is enriched in the ethyl ester fraction by the selective alcoholysis of fatty acid ethyl esters originating from tuna oil with lauryl alcohol.
    Ethyl docosa-4,7,10,13,16,19-hexaenoate
  • HY-130285
    10(S),17(S)-DiHDHA

    10(S),17(S)-DiHDoHE; PDX

    		 Endogenous Metabolite Inflammation/Immunology
    10(S),17(S)-DiHDHA (also known as neuroprotectin D1 when produced in neuronal tissues) is a DHA-derived dihydroxy fatty acid that exhibits potent protective and anti-inflammatory activities .
    10(S),17(S)-DiHDHA
  • HY-136540S
    Resolvin D3-d5

    RvD3-d5

    		 Isotope-Labeled Compounds Inflammation/Immunology
    Resolvin D3-d5 is the deuterium labeled Resolvin D3. Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation[1][2].
    Resolvin D3-d5
  • HY-130239A
    (±)14-HDHA

    (±)14-HDoHE; 14-hydroxy Docosahexaenoic acid; (±)14-HDoHE

    		 Drug Metabolite Neurological Disease
    (±)14-HDHA is the isomer of 14(S)-HDHA (HY-130239). 14(S)-HDHA is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway .
    (±)14-HDHA
  • HY-116429S
    Maresin 1-d5

    		Isotope-Labeled Compounds Reactive Oxygen Species Inflammation/Immunology
    Maresin 1-d5 is the deuterium labeled Maresin 1. Maresin 1, produced by human Mφs from endogenous docosahexaenoic acid (DHA) and a specialized proresolving mediator, stimulates intracellular [Ca2+] and secretion. Maresin 1 possesses anti-inflammatory activity[1][2][3].
    Maresin 1-d5
  • HY-121636
    Resolvin D2

    RvD2

    		 TRP Channel Infection Neurological Disease Inflammation/Immunology
    Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons .
    Resolvin D2
  • HY-107343
    Docosahexaenoic acid ethyl ester

    Ethyl docosahexaenoate

    		 Others Neurological Disease Metabolic Disease
    Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects .
    Docosahexaenoic acid ethyl ester
  • HY-N11286R
    Tridocosahexaenoylglycerol (Standard)

    		Others Neurological Disease Metabolic Disease Inflammation/Immunology
    Tridocosahexaenoylglycerol (Standard) is the analytical standard of Tridocosahexaenoylglycerol. This product is intended for research and analytical applications. Tridocosahexaenoylglycerol (TG-DHA) is an orally active dietary supplement that improves autoimmune encephalomyelitis in mice. Tridocosahexaenoylglycerol shows beneficial effects on neurodegenerative diseases and also improves macular function in diabetic retinopathy. Tridocosahexaenoylglycerol can be used for research on neurological diseases, inflammatory immune diseases, and metabolic diseases .
    Tridocosahexaenoylglycerol (Standard)
  • HY-Y0335
    1,3-Dihydroxyacetone

    Dihydroxyacetone

    		 Endogenous Metabolite Others
    1,3-Dihydroxyacetone (DHA), the main active ingredient in sunless tanning skin-care preparations and an important precursor for the synthesis of various fine chemicals, is produced on an industrial scale by microbial fermentation of glycerol (HY-B1659) in Gluconobacter oxydans. 1,3-Dihydroxyacetone is also used for synthesis of new biodegradable polymers by combining with lactic acid (HY-B2227) .
    1,3-Dihydroxyacetone
  • HY-101541S
    Docosahexaenoic acid-d5 methyl ester

    Methyl docosahexaenoate-d5; all cis-DHA methyl ester-d5

    		 Isotope-Labeled Compounds Neurological Disease
    Docosahexaenoic acid-d5 methyl ester is the deuterium labeled Docosahexaenoic Acid methyl ester. Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed[1][2].
    Docosahexaenoic acid-d5 methyl ester
  • HY-116124
    17(S)-HpDHA

    		Lipoxygenase Others
    17(S)-HpDHA is the main 15-Lipoxygenase (LOX) isoenzyme: h15-LOX-1 and h15-LOX-2 and docosahexaenoic acid (DHA). product. 17(S)-HpDHA negatively regulates epoxide synthesis via allosteric regulation. 17(S)-HpDHA also inhibits platelet aggregation with an EC50 of approximately 1 μM .
    17(S)-HpDHA
  • HY-W708469
    Resolvin D2 methyl ester

    		Endogenous Metabolite TRP Channel Inflammation/Immunology
    Resolvin D2 methyl ester is an ester derivative of the DHA (HY-B2167) metabolite Resolvin D2 (HY-121636) with anti-inflammatory and anti-infective activities. Resolvin D2 is a leukocyte modulator and a potent inhibitor of neuronal TRPV1 (IC50=0.1 nM) and TRPA1 (IC50=2 nM). Resolvin D2 can be used in sepsis research .
    Resolvin D2 methyl ester
  • HY-B0573
    Propranolol hydrochloride
    20+ Cited Publications

    		 Adrenergic Receptor Bacterial Neurological Disease Endocrinology Cancer
    Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively . Propranolol hydrochloride inhibits [ 3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM . Propranolol hydrochloride is used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .
    Propranolol hydrochloride
  • HY-B0573B
    Propranolol
    20+ Cited Publications

    		 Adrenergic Receptor Bacterial Cardiovascular Disease Neurological Disease Endocrinology Cancer
    Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively . Propranolol inhibits [ 3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM . Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy .
    Propranolol

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