Propranolol-d₇

Name: Propranolol-d 7
Brand: MedChemExpress
SKU: HY-B0573BS
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0573BS Purity: 98.15%: FAQs
Data Sheet SDS COA Handling Instructions

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Propranolol-d₇ is the deuterium labeled Propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3].

For research use only. We do not sell to patients.

Propranolol-d<sub>7</sub> Chemical Structure

Propranolol-d₇ Chemical Structure

CAS No. : 98897-23-5

Size	Price	Stock	Quantity
1 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Propranolol-d₇:

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

266.39

Formula

C₁₆H₁₄D₇NO₂

CAS No.

98897-23-5

Unlabeled CAS

525-66-6

Appearance

Solid

Color

White to off-white

SMILES

OC(COC1=C2C=CC=CC2=CC=C1)CNC([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (375.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7539 mL	18.7695 mL	37.5389 mL
5 mM	0.7508 mL	3.7539 mL	7.5078 mL
10 mM	0.3754 mL	1.8769 mL	3.7539 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (273 KB) SDS (251 KB)

COA (248 KB) Elemental Analysis Report (106 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. Epub 2006 Aug 1 [Content Brief]

[3]. Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73. [Content Brief]

[4]. Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338. [Content Brief]

[5]. Munabi NC, et al. Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation. Stem Cells Transl Med. 2016 Jan;5(1):45-55. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	3.7539 mL	18.7695 mL	37.5389 mL	93.8474 mL
	5 mM	0.7508 mL	3.7539 mL	7.5078 mL	18.7695 mL
	10 mM	0.3754 mL	1.8769 mL	3.7539 mL	9.3847 mL
	15 mM	0.2503 mL	1.2513 mL	2.5026 mL	6.2565 mL
	20 mM	0.1877 mL	0.9385 mL	1.8769 mL	4.6924 mL
	25 mM	0.1502 mL	0.7508 mL	1.5016 mL	3.7539 mL
	30 mM	0.1251 mL	0.6256 mL	1.2513 mL	3.1282 mL
	40 mM	0.0938 mL	0.4692 mL	0.9385 mL	2.3462 mL
	50 mM	0.0751 mL	0.3754 mL	0.7508 mL	1.8769 mL
	60 mM	0.0626 mL	0.3128 mL	0.6256 mL	1.5641 mL
	80 mM	0.0469 mL	0.2346 mL	0.4692 mL	1.1731 mL
	100 mM	0.0375 mL	0.1877 mL	0.3754 mL	0.9385 mL