Resolvin D2  (Synonyms: RvD2)

Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC₅₀ = 0.1 nM) and TRPA1 (IC₅₀ = 2 nM) in primary sensory neurons^[1][2][3].

TRP Channel^[3]

Resolvin D2 induces active resolution of inflammation with pulp-like tissue regeneration after root canal infection and thus maybe suitable for treating periapical lesions^[1].
Resolvin D2 decreases leukocyte:endothelial interactions in vivo by endothelial-dependent nitric oxide production, and direct modulation of leukocyte adhesion receptor expression^[2].
Peripheral administration of Resolvin D2 (10 ng; Intraplantar administration) potently inhibits inflammatory pain^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

376.49

C₂₂H₃₂O₅

810668-37-2

Liquid

Colorless to light yellow

CC/C=C\C[C@H](O)[C@H](O)/C=C/C=C/C=C\C=C\[C@@H](O)C/C=C\CCC(O)=O

Room temperature in continental US; may vary elsewhere.

Solution, -20°C, 2 years

• [1]. Siddiqui YD, et al. Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis. Front Immunol. 2019 Feb 26;10:307.  [Content Brief]

  [2]. Spite M, et al. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature. 2009 Oct 29;461(7268):1287-91.  [Content Brief]

  [3]. Park CK, et al. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.6. J Neurosci. 2011 Dec 14;31(50):18433-8.  [Content Brief]