DIM

By Targets:	ADC Linker (3) Androgen Receptor (1) Apoptosis (1) Autophagy (1) CDK (1) Liposome (1) Nuclear Hormone Receptor 4A/NR4A (4) PROTACs (1) Ser/Thr Protease (1) STAT (1)
By Research Areas:	Cancer (6) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	Azide (2) Alkynes (1)
Oligonucleotides:	Cationic Lipids (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15758

3,3'-Diindolylmethane Maximum Cited Publications 9 Publications Verification DIM; Arundine; HB 236	Androgen Receptor Autophagy	Cancer
3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.

HY-19808

*C-DIM12* 1 Publications Verification DIM-C-pPhCl	Nuclear Hormone Receptor 4A/NR4A	Neurological Disease Inflammation/Immunology Cancer
C-DIM12 is a potent, orally active Nurr1 antagonist. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study .

HY-112055

DIM-C-pPhOH 4 Publications Verification	Nuclear Hormone Receptor 4A/NR4A Apoptosis	Cancer
DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. DIM-C-pPhOH inhibits cancer cell growth and mTOR signaling, induce apoptosis and cellular stress. DIM-C-pPhOH reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells, respectively .

HY-111492

DIM-C-pPhOCH3 1 Publications Verification	Nuclear Hormone Receptor 4A/NR4A	Cancer
DIM-C-pPhOCH₃ is a Nur77 agonist. Nerve growth factor-induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor.

HY-112056

DIM-C-pPhCO2Me 1 Publications Verification	Nuclear Hormone Receptor 4A/NR4A	Cancer
DIM-C-pPhCO2Me is a nuclear receptor 4A1 (NR4A1) antagonist . Antineoplastic activity .

HY-49223

diMal-O-CH2COOH	ADC Linker	Cancer
diMal-O-CH2COOH is a cleavable ADC linker.

HY-149310

Dim16	Ser/Thr Protease	Metabolic Disease
Dim16 is a dual PCSK9/HMG-CoAR inhibitor, with an IC₅₀ value of 19 nM for PCSK9. Dim16 inhibits PCSK9-LDLR binding with an IC₅₀ value of 0.8 nM. Dim16 increases LDL uptake in HepG2 cells .

HY-159715

*Lipid DIM1*	Liposome	Others
Lipid DIM1 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid DIM1 is a carrier for both siRNA and mRNA .

HY-151786

*Fmoc-L-Lys(Pentynoyl-DIM)-OH*	ADC Linker	Others
Fmoc-L-Lys(Pentynoyl-DIM)-OH is a click chemistry reagent containing an azide. Fmoc-L-Lys(Pentynoyl-DIM)-OH can be used as a SPPS building block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151787

*Fmoc-L-Lys(N3-Aca-DIM)-OH*	ADC Linker	Others
Fmoc-L-Lys(N3-Aca-DIM)-OH is a click chemistry reagent containing an azide group. Used as a SPPS building-block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-N12703

N-Acetyldopamine dimmers A	Others	Inflammation/Immunology
N-Acetyldopamine dimmers A (Compound (+)-2) can be isolated from the cast-off shell of the cicada of Cryptotympana sp. N-Acetyldopamine dimmers A increases collagen and α-SMA expression .

HY-153991

STAT6-IN-2	STAT	Inflammation/Immunology
STAT6-IN-2 (Comp R-84) is an inhibitor of STAT6. STAT6-IN-2 inhibits the secretion of chemokine eliciting eosinophil infiltration eotaxin-3. STAT6-IN-2 can be used for immune disease research .

HY-163815

CDK2 degrader 2	PROTACs CDK	Others
CDK2 degrader 2 is a PROTAC class CDK2 degrader. The CDK2 binding moiety (CBM) binds to the CDK2 protein and subsequently undergoes ubiquitination, leading to the degradation of CDK2 through the ubiquitin proteasome pathway (UPP). CDK2 degrader 2 can cause degradation of CDK2 in MKN1 cells, with a DC₅₀ value less than 100 nM and an average D_max value greater than 75%. (Red: CBM; Blue: DIM; Black: linker)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15758

3,3'-Diindolylmethane 5+ Cited Publications DIM; Arundine; HB 236	Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Alkaloid Dimers Cancer	Androgen Receptor Autophagy
3,3'-Diindolylmethane is a strong, pure androgen receptor (AR) antagonist.

HY-N12703

N-Acetyldopamine dimmers A	Structural Classification Animals Source classification Phenols Polyphenols	Others
N-Acetyldopamine dimmers A (Compound (+)-2) can be isolated from the cast-off shell of the cicada of Cryptotympana sp. N-Acetyldopamine dimmers A increases collagen and α-SMA expression .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P77270

	TXNL4B Protein, Human (His) Thioredoxin-like protein 4B; DIM1-like protein; DIM2; DLP	Human	E. coli
	TXNL4B Protein, vital for pre-mRNA splicing, is crucial for S/G(2) cell cycle transition, forming homodimers and interacting with the U5-102 kDa spliceosome subunit. It plays a key role in splicing intricacies and influences cell cycle dynamics. TXNL4B Protein, Human (His) is the recombinant human-derived TXNL4B protein, expressed by E. coli , with N-His labeled tag. The total length of TXNL4B Protein, Human (His) is 149 a.a., with molecular weight of ~19 kDa.

HY-P77269

	TXNL4A Protein, Human (His) Thioredoxin-like protein 4A; DIM1 protein homolog; DIM1; TXNL4	Human	E. coli
	The TXNL4A protein plays a key role in pre-mRNA splicing and is an important component of U5 snRNP, U4/U6-U5 tri-snRNP complex, and precatalytic spliceosome (spliceosome B complex). It contributes to spliceosome assembly and is an integral part of the complex process of spliceosome function. TXNL4A Protein, Human (His) is the recombinant human-derived TXNL4A protein, expressed by E. coli , with N-His labeled tag. The total length of TXNL4A Protein, Human (His) is 142 a.a., with molecular weight of ~14 kDa.

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Cat. No.	Product Name		Classification

HY-151786

*Fmoc-L-Lys(Pentynoyl-DIM)-OH*		Alkynes Azide
Fmoc-L-Lys(Pentynoyl-DIM)-OH is a click chemistry reagent containing an azide. Fmoc-L-Lys(Pentynoyl-DIM)-OH can be used as a SPPS building block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-151787

*Fmoc-L-Lys(N3-Aca-DIM)-OH*		Azide
Fmoc-L-Lys(N3-Aca-DIM)-OH is a click chemistry reagent containing an azide group. Used as a SPPS building-block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilizing residues are attached to the Lys side-chains using Click-chemistry. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Cat. No.	Product Name		Classification

HY-159715

*Lipid DIM1*		Cationic Lipids
Lipid DIM1 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid DIM1 is a carrier for both siRNA and mRNA .

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