2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. Dim16

Dim16 is a dual PCSK9/HMG-CoAR inhibitor, with an IC50 value of 19 nM for PCSK9. Dim16 inhibits PCSK9-LDLR binding with an IC50 value of 0.8 nM. Dim16 increases LDL uptake in HepG2 cells.

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Dim16 Chemical Structure

Dim16 Chemical Structure

CAS No. : 2743448-32-8

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Dim16 Related Antibodies

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Description

Dim16 is a dual PCSK9/HMG-CoAR inhibitor, with an IC50 value of 19 nM for PCSK9. Dim16 inhibits PCSK9-LDLR binding with an IC50 value of 0.8 nM. Dim16 increases LDL uptake in HepG2 cells[1].

IC50 & Target

19 nM (PCSK9)[1]
Molecular Weight

583.55

Formula

C29H38IN5
CAS No.
SMILES

CC(C)(C)CCCN1C(C2=CN=C(N2CCCCCNC)I)=NC=C1C3=CC=C4C=CC=CC4=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dim16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dim162743448-32-8Dim 16Dim-16Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesLDLRLDL uptakeHepG2 cellcholesterolInhibitorinhibitorinhibit

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