CDK2 degrader 2

Cat. No.: HY-163815: FAQs
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CDK2 degrader 2 is a PROTAC class CDK2 degrader. The CDK2 binding moiety (CBM) binds to the CDK2 protein and subsequently undergoes ubiquitination, leading to the degradation of CDK2 through the ubiquitin proteasome pathway (UPP). CDK2 degrader 2 can cause degradation of CDK2 in MKN1 cells, with a DC₅₀ value less than 100 nM and an average D_max value greater than 75%. (Red: CBM; Blue: DIM; Black: linker)

For research use only. We do not sell to patients.

CDK2 degrader 2 Chemical Structure

CAS No. : 3030271-16-7

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1 mg	USD 1380	Ask For Quote & Lead Time
5 mg	USD 3000	Ask For Quote & Lead Time
10 mg	USD 4900	Ask For Quote & Lead Time

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Description	CDK2 degrader 2 is a PROTAC class CDK2 degrader. The CDK2 binding moiety (CBM) binds to the CDK2 protein and subsequently undergoes ubiquitination, leading to the degradation of CDK2 through the ubiquitin proteasome pathway (UPP). CDK2 degrader 2 can cause degradation of CDK2 in MKN1 cells, with a DC₅₀ value less than 100 nM and an average D_max value greater than 75%. (Red: CBM; Blue: DIM; Black: linker)
Molecular Weight	913.53
Formula	C₄₆H₅₇ClN₁₀O₆S
CAS No.	3030271-16-7
SMILES	O=C1C(Cl)=CC2=C(N1C(C)C)N=C(NC3=CC=C(S(=O)(C4CCN(C5CCN(CC6CCN(CC6)C7=C(N(C)C(N8C9C(NC(CC9)=O)=O)=O)C8=CC=C7)CC5)CC4)=O)C=C3C)N=C2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (263 KB) Handling Instructions (2659 KB)
References	[1]. Collier, Philip, et al. CDK2 DEGRADERS AND USES THEREOF. US, US20240173419A1. 2024-05-30.

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2 degrader 23030271-16-7PROTACsCDKCyclin dependent kinasePROTACdegraderMKN1 cellInhibitorinhibitorinhibit

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