2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs CDK
  4. CDK2 degrader 2

CDK2 degrader 2 is a PROTAC class CDK2 degrader. The CDK2 binding moiety (CBM) binds to the CDK2 protein and subsequently undergoes ubiquitination, leading to the degradation of CDK2 through the ubiquitin proteasome pathway (UPP). CDK2 degrader 2 can cause degradation of CDK2 in MKN1 cells, with a DC50 value less than 100 nM and an average Dmax value greater than 75%. (Red: CBM; Blue: DIM; Black: linker)

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CDK2 degrader 2 Chemical Structure

CDK2 degrader 2 Chemical Structure

CAS No. : 3030271-16-7

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Based on 1 publication(s) in Google Scholar

CDK2 degrader 2 Related Antibodies

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Description

CDK2 degrader 2 is a PROTAC class CDK2 degrader. The CDK2 binding moiety (CBM) binds to the CDK2 protein and subsequently undergoes ubiquitination, leading to the degradation of CDK2 through the ubiquitin proteasome pathway (UPP). CDK2 degrader 2 can cause degradation of CDK2 in MKN1 cells, with a DC50 value less than 100 nM and an average Dmax value greater than 75%. (Red: CBM; Blue: DIM; Black: linker)

Molecular Weight

913.53

Formula

C46H57ClN10O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(Cl)=CC2=C(N1C(C)C)N=C(NC3=CC=C(S(=O)(C4CCN(C5CCN(CC6CCN(CC6)C7=C(N(C)C(N8C9C(NC(CC9)=O)=O)=O)C8=CC=C7)CC5)CC4)=O)C=C3C)N=C2
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (109.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0947 mL 5.4733 mL 10.9465 mL
5 mM 0.2189 mL 1.0947 mL 2.1893 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0947 mL 5.4733 mL 10.9465 mL 27.3664 mL
5 mM 0.2189 mL 1.0947 mL 2.1893 mL 5.4733 mL
10 mM 0.1095 mL 0.5473 mL 1.0947 mL 2.7366 mL
15 mM 0.0730 mL 0.3649 mL 0.7298 mL 1.8244 mL
20 mM 0.0547 mL 0.2737 mL 0.5473 mL 1.3683 mL
25 mM 0.0438 mL 0.2189 mL 0.4379 mL 1.0947 mL
30 mM 0.0365 mL 0.1824 mL 0.3649 mL 0.9122 mL
40 mM 0.0274 mL 0.1368 mL 0.2737 mL 0.6842 mL
50 mM 0.0219 mL 0.1095 mL 0.2189 mL 0.5473 mL
60 mM 0.0182 mL 0.0912 mL 0.1824 mL 0.4561 mL
80 mM 0.0137 mL 0.0684 mL 0.1368 mL 0.3421 mL
100 mM 0.0109 mL 0.0547 mL 0.1095 mL 0.2737 mL
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CDK2 degrader 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK2 degrader 23030271-16-7PROTACsCDKCyclin dependent kinasePROTACdegraderMKN1 cellInhibitorinhibitorinhibit

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