2. Vitamin D Related/Nuclear Receptor
  3. Nuclear Hormone Receptor 4A/NR4A
  4. C-DIM12

C-DIM12  (Synonyms: DIM-C-pPhCl)

Cat. No.: HY-19808 Purity: 98.32%
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C-DIM12 is a potent, orally active Nurr1 antagonist. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study.

For research use only. We do not sell to patients.

C-DIM12 Chemical Structure

C-DIM12 Chemical Structure

CAS No. : 178946-89-9

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Based on 1 publication(s) in Google Scholar

C-DIM12 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE C-DIM12

View All Nuclear Hormone Receptor 4A/NR4A Isoform Specific Products:

View All Isoforms
Nurr1/NR4A2 Nur77/NR4A1

  • Biological Activity

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Description

C-DIM12 is a potent, orally active Nurr1 antagonist. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study[1][2][3].

IC50 & Target

Nurr1/NR4A2

 

In Vitro

C-DIM12 (15 μM, 3-5 day) increases cell proliferation and survival by inhibiting autophagy in MiaPaCa2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C-DIM12 Related Antibodies
In Vivo

C-DIM12 (25 mg/kg for i.p., 14 day) modulates glial reactivity in MPTP-Induced Parkinsonism mice[2].
C-DIM12 (50-100 mg/kg for i.p., three times ) attenuates brain inflammation and improves functional recovery after intracerebral hemorrhage in mice[3].
C-DIM12 (30 mg/kg for i.p., 30 day) inhibits tumor growth and autophagy, and induces apoptosis in NURR1-KO cells orthotopic xenograft[1].
Pharmacokinetic Analysis in C57BL/6 male mice[1]

Route Organ Dose (mg/kg) Area under Curve (ng/mL*min) t1/2 (min) Cmax (ng/mL)
i.g. Plasma 25 539,220 249 1120
i.g. Brain 25 2,273,711 265 3622

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MPTP-induced C57BL/6 male Parkinsonism mice [2]
Dosage: 25 mg/kg/day, 14day
Administration: Intragastric gavage (i.g.)
Result: Protected against the loss of DA neurons in the substantia nigra pars compacta and DA terminals in the striatum, maintained a ramified phenotype in microglia, and suppressed activation of astrocytes.
Animal Model: The ICR mice model of intracerebral hemorrhage induced by collagenase type VII[3]
Dosage: 50 and 100mg/kg/day at a 24-h interval, three times
Administration: Orally administration
Result: Improved the recovery of neurological function and prevented neuron loss in the hematoma, while suppressed activation of microglia/macrophages and expression of inflammatory mediators interleukin-6 and CC chemokine ligand 2.
Preserved axonal structures in the internal capsule and axonal transport function.
Decreased of iNOS mRNA expression.
Animal Model: MiaPaCa2 cells (Ctrl and NURR1-KO) orthotopic xenograft tumor models[1]
Dosage: 30 mg/kg, 30 day
Administration: Intraperitoneal injection (i.p.)
Result: Inhibited tumor growth and ATG7 and ATG12 mRNA levels, and induced apoptosis.
Molecular Weight

356.85

Formula

C23H17ClN2
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (280.23 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8023 mL 14.0115 mL 28.0230 mL
5 mM 0.5605 mL 2.8023 mL 5.6046 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8023 mL 14.0115 mL 28.0230 mL 70.0574 mL
5 mM 0.5605 mL 2.8023 mL 5.6046 mL 14.0115 mL
10 mM 0.2802 mL 1.4011 mL 2.8023 mL 7.0057 mL
15 mM 0.1868 mL 0.9341 mL 1.8682 mL 4.6705 mL
20 mM 0.1401 mL 0.7006 mL 1.4011 mL 3.5029 mL
25 mM 0.1121 mL 0.5605 mL 1.1209 mL 2.8023 mL
30 mM 0.0934 mL 0.4670 mL 0.9341 mL 2.3352 mL
40 mM 0.0701 mL 0.3503 mL 0.7006 mL 1.7514 mL
50 mM 0.0560 mL 0.2802 mL 0.5605 mL 1.4011 mL
60 mM 0.0467 mL 0.2335 mL 0.4670 mL 1.1676 mL
80 mM 0.0350 mL 0.1751 mL 0.3503 mL 0.8757 mL
100 mM 0.0280 mL 0.1401 mL 0.2802 mL 0.7006 mL
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C-DIM12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C-DIM12178946-89-9DIM-C-pPhClNuclear Hormone Receptor 4A/NR4ANerve Growth Factor IB-like ReceptorPancreatic ductal adenocarcinomaMiaPaCa2Parkinsonismintracerebral hemorrhageinflammationapoptosisautophagyInhibitorinhibitorinhibit

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