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Hdm2 E3 ligase inhibitor 1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-131667
    Hdm2 E3 ligase inhibitor 1

    		MDM-2/p53 E1/E2/E3 Enzyme Cancer
    Hdm2 E3 ligase inhibitor 1 (Compound 1) is a reversible inhibitor for Hdm2 (an E3 ubiquitin ligase)-mediated ubiquitination of the p53 protein with an IC50 of 12.7 μM. Hdm2 E3 ligase inhibitor 1 binds Hdm2, blocks Hdm2-catalyzed ubiquitin transfer from preligated Ub-Ubc4 to p53, inhibits p53 ubiquitination, stabilizes p53 protein in tumor cell and exhibits antitumor efficacy .
    Hdm2 E3 ligase inhibitor 1

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