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IK1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Endogenous Metabolite (1) Potassium Channel (1)
By Research Areas:	Cardiovascular Disease (2) Neurological Disease (1)

3

Inhibitors & Agonists

2

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

IK1 inhibitor PA-6 1 Publications Verification PA-6	Potassium Channel	Cardiovascular Disease
IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent *I_K1* (K_IR2.x ion-channel-carried inward rectifier current) inhibitor, with IC₅₀ values of 12-15 nM for human and mouse K_IR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates K_IR2.1 protein expression and induces intracellular K_IR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia ^[1] .

Zacopride hydrochloride	5-HT Receptor	Neurological Disease
Zacopride hydrochloride is a highly potent 5-HT₃ receptor antagonist with K_is of 0.38 and 373 nM for 5-HT₃ and 5-HT₄ receptor, respectively. Zacopride hydrochloride is also a moderate *I_K1* channel agonist. Zacopride hydrochloride exerts significant antiarrhythmic and cardiac protective effects ^[1] .

Zacopride	Endogenous Metabolite	Cardiovascular Disease
Zacopride is a selective agonist with the activity of enhancing the inward rectifier potassium current (IK1) in rabbit hearts. Zacopride also exhibits significant antiarrhythmic effects, inhibiting ventricular arrhythmias by increasing IK1 without affecting atrial arrhythmias. Zacopride can hyperpolarize the resting membrane potential and shorten the action potential duration (APD) in a concentration-dependent manner. Zacopride significantly reduced the incidence of compound-induced early afterdepolarizations (EADs) at 1 μmol/L ^[1].

Cat. No.	Compare	Product Name	Application	Reactivity

	Ikaros Antibody (YA987) CLL associated antigen KW 6; DNA-binding protein IKaros; hIK 1; hIK-1; Hs.54452; IK1; IKaros (zinc finger protein); IKAROS; IKAROS family zinc finger 1 (IKaros); IKaros family zinc finger protein 1; IKzf1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subfamily 1A 1 (IKaros); zinc finger protein subfamily 1A 1; Zinc finger protein; subfamily 1A; member 1; ZNFN1A1.	WB, IP	Human
	Ikaros Antibody (YA987) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA987), targeting Ikaros, with a predicted molecular weight of 58 kDa (observed band size: 58 kDa). Ikaros Antibody (YA987) can be used for WB, IP experiment in human background.

	Ikaros Antibody (YA988) CLL associated antigen KW 6; DNA-binding protein IKaros; hIK 1; hIK-1; Hs.54452; IK1; IKaros (zinc finger protein); IKAROS; IKAROS family zinc finger 1 (IKaros); IKaros family zinc finger protein 1; IKzf1; IKZF1_HUMAN; LYF1; Lymphoid transcription factor LyF-1; PRO0758; Zinc finger protein subfamily 1A 1 (IKaros); zinc finger protein subfamily 1A 1; Zinc finger protein; subfamily 1A; member 1; ZNFN1A1.	IHC-P	Human
	Ikaros Antibody (YA988) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA988), targeting Ikaros. Ikaros Antibody (YA988) can be used for IHC-P experiment in human background.

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