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LY3410738 (gentisate)

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-131312A
    Crelosidenib (gentisate)

    LY3410738 (gentisate); Mutant IDH1-IN-6 (gentisate)

    		 Isocitrate Dehydrogenase (IDH) Cancer
    Crelosidenib (gentisate) is a potent, selective and orally active mutant isocitrate dehydrogenase (IDH) inhibitor with IC50 of 6.27 nM, 3.71 nM, 36.9 nM and 11.5 nM for IDH1 R132H, IDH1 R132C, IDH2 R140Q and IDH2 R172K mutant enzymes, respectively. Crelosidenib (gentisate) is less active at inhibiting the IDH wild-type enzymes .
    Crelosidenib (gentisate)

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