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Pathways Recommended: PROTAC
Results for "

PROTAC AR Degrader-9

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-30756
    tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate

    		PROTAC Linkers Others
    tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate is a PROTAC linker. tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate is the linker of PROTAC ER Degrader-12 (HY-160264) and PROTAC AR Degrader-9 (HY-170332) .
    tert-Butyl 2,7-diazaspiro[3.5]nonane-2-carboxylate
  • HY-170448
    PROTAC AR Degrader-9

    		PROTACs Androgen Receptor Endocrinology
    PROTAC AR Degrader-9 (Compound c6) is a PROTAC degrader for androgen receptor, that degrades AR in human hair follicle papilla cells (HDPCs) with a DC50 of 262.38 nM. PROTAC AR Degrader-9 promotes the expressions of paracrine factors, such as TGF-β1 and β-catenin, exhibits hair regenerating efficacy in mouse models . (Pink: ligand for target protein AR ligand-38 (HY-170450); Black: linker; Blue: ligand for E3 ligase Cereblon (HY-170449))
    PROTAC AR Degrader-9
  • HY-170450
    AR ligand-38

    		Androgen Receptor Ligands for Target Protein for PROTAC Endocrinology
    AR ligand-38 is the ligand for androgen receptor, that can be used for synthesis of PROTAC AR Degrader-9 (HY-170448) .
    AR ligand-38
  • HY-147100
    α1A-AR Degrader 9c

    		PROTACs Adrenergic Receptor Cancer
    α1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible α1A-AR (Adrenergic receptor) PROTAC degrader, with a DC50 of 2.86 μM. α1A-AR Degrader 9c induces α1A-AR degradation can be attributed to proteasomal degradation. α1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC50 of 6.12 μM. α1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research .
    α1A-AR Degrader 9c

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