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Results for "

Phosphodiesterase 4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phosphodiesterase (PDE) (47) 5-HT Receptor (1) Adrenergic Receptor (1) Apoptosis (1) Autophagy (1) Calcium Channel (2) Dopamine Receptor (1) Endogenous Metabolite (1) Fungal (1) Histamine Receptor (3) Influenza Virus (1) Isotope-Labeled Compounds (1) JAK (1) MMP (1) NF-κB (2) p38 MAPK (1) TNF Receptor (1)
By Research Areas:	Cancer (8) Endocrinology (1) Infection (3) Inflammation/Immunology (39) Metabolic Disease (2) Neurological Disease (10)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Phosphodiesterase (PDE)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19672

Lirimilast BAY 19-8004	Phosphodiesterase (PDE)	Inflammation/Immunology
Lirimilast (BAY 19-8004) is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC₅₀ value of 49 nM. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease (COPD). Lirimilast has potently anti-inflammatory properties .

HY-109085

Difamilast 2 Publications Verification OPA-15406	Phosphodiesterase (PDE)	Inflammation/Immunology
Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC₅₀=11.2 nM). Difamilast can be used for the research of mild to moderate atopic dermatitis (AD) .

HY-15178

Oglemilast GRC 3886	Phosphodiesterase (PDE)	Inflammation/Immunology
Oglemilast (GRC 3886) is a potent and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC₅₀ of 0.5 nM for PDE4D3. Oglemilast inhibits pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo. Oglemilast has the potential for inflammatory airway diseases .

HY-130786

Denbufylline BRL 30892	Phosphodiesterase (PDE)	Others Inflammation/Immunology
Denbufylline (BRL 30892) is an inhibitor of phosphodiesterase-4 (PDE4). Denbufylline is able to block the degradation of intracellular cAMP (cyclic adenosine phosphate) thereby increasing the level of intracellular cAMP, which helps regulate a variety of cellular functions. Denbufylline can be used in the study of chronic obstructive pulmonary disease (COPD), asthma and other inflammatory diseases .

HY-122942

Moracin M	Phosphodiesterase (PDE) Endogenous Metabolite NF-κB Autophagy	Inflammation/Immunology
Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent phosphodiesterase-4 (PDE4) inhibitor with IC₅₀ values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity .

HY-U00254

L791943	Phosphodiesterase (PDE)	Neurological Disease
L791943 is a potent, selective *Phosphodiesterase-4* (PDE4) inhibitor with an IC₅₀ of 4.2 nM.

HY-N2958

Braylin	Phosphodiesterase (PDE)	Inflammation/Immunology
Braylin, a coumarin, is a potent phosphodiesterase-4 (PDE4) inhibitor and is involved in anti-inflammatory and immunomodulation, which may serve as a potential target for the study of immunoinflammatory diseases .

HY-19393

SCH 351591	Phosphodiesterase (PDE)	Inflammation/Immunology
SCH 351591 is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC₅₀ of 58 nM. SCH 351591 can inhibit all 4 PDE4 subtypes (A, B, C, and D). SCH 351591 has the potential for the asthma and chronic obstructive pulmonary disease (COPD) research .

HY-109085R

Difamilast (Standard)	Phosphodiesterase (PDE)	Inflammation/Immunology
Difamilast (Standard) is the analytical standard of Difamilast. This product is intended for research and analytical applications. Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC₅₀=11.2 nM). Difamilast can be used for the research of mild to moderate atopic dermatitis (AD) .

HY-108047

MK-0873	Phosphodiesterase (PDE)	Metabolic Disease Inflammation/Immunology
MK-0873 is a selective phosphodiesterase-4 (PDE4) inhibitor. MK-0873 increases intracellular levels of cyclic adenosine phosphate (cAMP) by inhibiting the activity of the PDE4 enzyme and subsequently activates protein kinase A (PKA). Activated PKA inhibits the activity of inflammatory cells and leads to direct relaxation of airway smooth muscle. MK-0873 can be used in studies of chronic obstructive pulmonary disease (COPD) .

HY-N11431

ent-Toddalolactone	Others	Cancer
ent-Toddalolactone is a natural compound with anti-inflammatory and anticancer activities. Ent-Toddalolactone has shown inhibitory effects on phosphodiesterase-4 (PDE4) in vitro and is a potential drug target for inhibiting asthma and chronic obstructive pulmonary disease. The activity of ent-Toddalolactone is related to its unique chemical structure, and some of its derivatives showed IC₅₀ values below 10 μM in inhibition experiments, showing high biological activity .

HY-128358

MR-L2	Phosphodiesterase (PDE)	Neurological Disease
MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC₅₀ of 1.2 µM .

HY-124388

PDE4-IN-20	Others	Inflammation/Immunology
PDE4-IN-20 is a selective submicromolar phosphodiesterase-4 (PDE4) inhibitor with anti-TNF-α properties. PDE4-IN-20 exhibits significant biological activity in vitro and in vivo. The mechanism of action of PDE4-IN-20 is supported by molecular modeling studies, which reveal its binding mode with PDE4. PDE4-IN-20 was optimized in further conformational analysis and showed pharmacological characteristics similar to those of known PDE4 inhibitors .

HY-101803

CP671305	Phosphodiesterase (PDE)	Others
CP671305 is a potent, orally active, selective inhibitor of *phosphodiesterase-4-D*, and possesses high activities.

HY-145583

Mufemilast Hemay005	Phosphodiesterase (PDE)	Others
Mufemilast is a phosphodiesterase 4 (PDE4) inhibitor .

HY-12740

Lotamilast RVT-501; E6005	Phosphodiesterase (PDE)	Inflammation/Immunology
Lotamilast (RVT-501; E6005) is a selective phosphodiesterase 4 (PDE4) inhibitor with an IC₅₀ of 2.8 nM.

HY-12887

Piclamilast RP 73401; RPR 73401	Phosphodiesterase (PDE)	Inflammation/Immunology Cancer
Piclamilast (RP 73401) is a phosphodiesterase 4 (PDE4) inhibitor, with IC₅₀ values of 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively .

HY-N10317

Toddacoumalone	Phosphodiesterase (PDE)	Inflammation/Immunology
Toddacoumalone is a natural inhibitor of phosphodiesterase 4 (PDE4) with moderate potency and imperfect agent-like properties. Toddacoumalone has the potential for the research of inflammatory diseases such as psoriasis .

HY-U00179

CDC801	Phosphodiesterase (PDE) TNF Receptor	Cancer
CDC801 is a potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α (TNF-α) inhibitor with IC₅₀ of 1.1 μM and 2.5 μM, respectively.

HY-70069

GSK256066 Trifluoroacetate 1 Publications Verification	Phosphodiesterase (PDE)	Inflammation/Immunology
GSK256066 Trifluoroacetate is a selective and high-affinity phosphodiesterase 4 (PDE) inhibitor, with an IC₅₀ of 3.2 pM for PDE4B. GSK256066 Trifluoroacetate is developed for the research of chronic obstructive pulmonary disease .

HY-12348

LEO 29102	Phosphodiesterase (PDE)	Inflammation/Immunology
LEO 29102 is a potent phosphodiesterase 4 (PDE4) inhibitor with an IC₅₀ value of 5 nM. LEO 29102 inhibits TNFα release. LEO 29102 has the potential for the research of atopic dermatitis .

HY-19929A

(R)-Tanimilast (R)-CHF-6001	Phosphodiesterase (PDE)	Inflammation/Immunology
(R)-Tanimilast is a isomeride of Tanimilast (HY-19929). Tanimilast (CHF-6001) is a novel highly potent and selective *phosphodiesterase 4* inhibitor(IC₅₀=0.026 ± 0.006 nM) .

HY-A0027

Fenspiride hydrochloride	Histamine Receptor Phosphodiesterase (PDE)	Inflammation/Immunology Endocrinology
Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), *phosphodiesterase 4* (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC₅₀ values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases .

HY-A0027A

Fenspiride	Histamine Receptor Phosphodiesterase (PDE)	Inflammation/Immunology
Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), *phosphodiesterase 4* (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC₅₀ values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases .

HY-106137

Tofimilast	Phosphodiesterase (PDE)	Neurological Disease Inflammation/Immunology
Tofimilast is an inhibitor of Phosphodiesterase 4 (PDE4) with an IC₅₀ of 0.14 μM. Tofimilast exerts its anti-inflammatory effects by inhibiting the activity of PDE4, thereby increasing intracellular levels of cAMP .

HY-10469

GSK256066 1 Publications Verification	Phosphodiesterase (PDE)	Inflammation/Immunology
GSK256066 is a selective and high-affinity phosphodiesterase 4 (PDE4) inhibitor, with an IC₅₀ of 3.2 pM for PDE4B. GSK256066 is developed for the research of chronic obstructive pulmonary disease .

HY-108617

YM976	Phosphodiesterase (PDE)	Inflammation/Immunology
YM976 is a *phosphodiesterase 4* (PDE4) inhibitor with an IC₅₀ of 2.2 nM. YM976 shows the dissociation of anti-inflammatory activities from emetic effects and inhibits the antigen-induced airway responses .

HY-162581

FCPR16	Phosphodiesterase (PDE)	Inflammation/Immunology
FCPR16 is a Phosphodiesterase 4 (PDE4) inhibitor. FCPR16 increases the levels of cAMP in SH-SY5Y cells. FCPR16 can be used in the study of Parkinson's disease .

HY-117571

Zatolmilast 2 Publications Verification BPN14770	Phosphodiesterase (PDE)	Neurological Disease
Zatolmilast (BPN14770) is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC₅₀s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively .

HY-A0027AS

Fenspiride-d5	Isotope-Labeled Compounds Histamine Receptor Phosphodiesterase (PDE)	Inflammation/Immunology
Fenspiride-d₅ is the deuterium labeled Fenspiride. Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases[1][2][3].

HY-121162

Mesembrine (+)-Mesembrine	5-HT Receptor Phosphodiesterase (PDE)	Neurological Disease
Mesembrine ((+)-Mesembrine) a main alkaloid that features an aryloctahydroindole skeleton. Mesembrine is a 5-HT transporter inhibitor with a K_i of 1.4 nM. Mesembrine also inhibits phosphodiesterase 4B (PDE4B) with an IC₅₀ of 7.8 μM .

HY-147263

Dovramilast CC-11050	Phosphodiesterase (PDE)	Infection Inflammation/Immunology
Dovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor and can reduce the inflammatory response and improves Isoniazid (INH)-mediated bacillary clearance from the lungs. Dovramilast, as an adjunct, is used for the research of tuberculosis (TB) .

HY-12887R

Piclamilast (Standard)	Phosphodiesterase (PDE)	Inflammation/Immunology Cancer
Piclamilast (Standard) is the analytical standard of Piclamilast. This product is intended for research and analytical applications. Piclamilast (RP 73401) is a phosphodiesterase 4 (PDE4) inhibitor, with IC₅₀ values of 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively .

HY-B0392

(S)-(+)-Rolipram (+)-Rolipram; (S)-Rolipram	Phosphodiesterase (PDE) Apoptosis	Neurological Disease Inflammation/Immunology Cancer
(S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC₅₀ of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells .

HY-A0140

Drotaverine	Others	Neurological Disease
Drotaverine is a selective phosphodiesterase 4 inhibitor with angina relief activity. Drotaverine is used to suppress angina, including pain in the gastrointestinal tract and biliary tract. Drotaverine may also cause compound-induced priapism, a side effect of sustained penile erection .

HY-19929

Tanimilast CHF-6001	Phosphodiesterase (PDE)	Inflammation/Immunology
Tanimilast (CHF-6001) is a novel highly potent and selective *phosphodiesterase 4* inhibitor(IC₅₀=0.026 ± 0.006 nM) with robust anti-inflammatory activity and suitable for topical pulmonary administration.Tanimilast is used for the research of obstructive lung diseases .

HY-106996

AWD 12-281 GW 842470	Phosphodiesterase (PDE)	Inflammation/Immunology
AWD 12-281 is an orally active and highly selective phosphodiesterase 4 (PDE4) inhibitor (IC₅₀ = 9.7 nM). AWD 12-281 is used in the study of allergic dermatitis, asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis .

HY-106003

GSK356278	Phosphodiesterase (PDE)	Neurological Disease Inflammation/Immunology
GSK356278 is a potent, selective, orally bioavailable and brain-penetrant inhibitor of phosphodiesterase 4 (PDE4), with pIC₅₀s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory activity, and exhibits anxiolytic and cognition-enhancing effects .

HY-108621

RS-25344 hydrochloride	Phosphodiesterase (PDE)	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
RS-25344 hydrochloride is a selective *cAMP-phosphodiesterase 4* (PDE 4; PDE IV) inhibitor with an IC₅₀** of 0.28 nM in human lymphocytes. RS-25344 hydrochloride has only weak inhibitory effects on PDE I, II, III (IC₅₀ of >100 μM, 160 μM, 330 μM, respectively). RS-25344 hydrochloride has anti-inflammatory, memory- and cognition enhancing, and antineoplastic effects .

HY-121037

Eggmanone EGM1	Phosphodiesterase (PDE)	Cancer
Eggmanone (EGM1) is a potent and selective phosphodiesterase 4 (PDE4) antagonist with an IC₅₀ of 72 nM for PDE4D3. Eggmanone shows approximately 40- to 50-fold selective for PDE4D3 over other PDEs. Eggmanone exerts its Hh-inhibitory effects through selective antagonism of PDE4, leading to protein kinase A activation and subsequent Hh blockade .

HY-163777

Talaroterphenyl A	Phosphodiesterase (PDE)	Others Inflammation/Immunology
Talaroterphenyl A (compound 1) is a p-terphenyl derivative present in the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41412, which exhibits phosphodiesterase 4 (PDE4) inhibitory activity (IC₅₀=1.2 μM). Talaroterphenyl A also exhibits anti-inflammatory and anti-fibrotic activities, significantly reducing the mRNA levels of pro-inflammatory cytokines IL-6, TNF-α, and IL-1β .

HY-161936

Z21115	Phosphodiesterase (PDE)	Inflammation/Immunology
Z21115 is an orally active inhibitor for *phosphodiesterase 4* (PDE4), that inhibits PDE4D7 with IC₅₀ of 10.5 nM. Z21115 inhibits Lipopolysaccharide (HY-D1056)-induced expression of IL-6, TNF-α and iNOS. Z21115 exhibits anti-inflammatory activity in DSS (HY-116282)-induced mouse colitis models without significant toxicity (1 g/kg) .

HY-101762

TyK2-IN-2	JAK Phosphodiesterase (PDE)	Inflammation/Immunology
TyK2-IN-2 (Compoud 18) is a potent and selective TYK2 inhibitor with IC₅₀s of 7 nM, 0.1 μM and 0.05 μM for TYK2 JH2, IL-23 and IFNα, respectively. TyK2-IN-2 also inhibits phosphodiesterase 4 (PDE4) with an IC₅₀ of 62 nM. TyK2-IN-2 can be used for the research of inflammatory and autoimmune diseases .

HY-117977

FCPR03	Phosphodiesterase (PDE)	Neurological Disease Inflammation/Immunology
FCPR03 is a potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC₅₀ values of 60 nM, 31 nM and 47 nM for PDE4 catalytic domain, PDE4B1 and PDE4D7, respectively. FCPR03 displays at least 2100-fold selectivity over other PDEs (PDE1-3 and PDE5-11). FCPR03 has anti-inflammatory, neuroprotective and antidepressant-like effects .

HY-126167

Deacetylsclerotiorin	Fungal Phosphodiesterase (PDE)	Infection
Deacetylsclerotiorin is a secondary metabolite of chloramphenicol isolated from the fungus Bartalinia robillardoides strain LF550. Deacetylsclerotiorin has significant inhibitory effects on Candida albicans (IC₅₀=24 μM), Trichophyton rubrum (IC₅₀=2.83 μM) and Septoria tritici (IC₅₀=7..45 μM). In addition, Deacetylsclerotiorin also exhibits inhibitory effects on the enzyme phosphodiesterase 4 (PDE4) (IC₅₀=2.8 μM) .

HY-111164

CBS-3595	p38 MAPK Phosphodiesterase (PDE)	Inflammation/Immunology
CBS-3595 is a dual inhibitor of p38 MAP kinase and *phosphodiesterase 4* with anti-inflammatory and anti-allodynic activities. CBS-3595 reduces the production of the proinflammatory cytokine IL-6 and increases the levels of the anti-inflammatory cytokine IL-10 in rats. CBS-3595 reduces paw oedema formation in the Complete Freund’s adjuvant (CFA) (HY-153808)-induced arthritis rat model. CBS-3595 is promising for research of autoimmune diseases .

HY-10790

Cilomilast 1 Publications Verification SB-207499	Phosphodiesterase (PDE)	Inflammation/Immunology
Cilomilast (SB-207499) is a potent, selective and orally active inhibitor of Phosphodiesterase 4 (PDE4), with IC₅₀s of ~100 and 120 nM for LPDE4 and HPDE4, respectively. Cilomilast shows selectivity for PDE4 over PDE1, PDE2, PDE3 and PDE5 (IC₅₀=74, 65, >100, and 83 μM, respectively). Cilomilast has anti-inflammatory and immunomodulatory effects and can be used for thr research of asthma and chronic obstructive pulmonary disease (COPD) .

HY-119799

UK-500001	Phosphodiesterase (PDE)	Inflammation/Immunology
UK-500001 is an orally active inhibitor for *phosphodiesterase 4* (PDE4), which inhibits PDE4D3 (IC₅₀ is 0.28 nM), PDE4B2 (IC₅₀ is 22.8 nM), PDE4A4 (IC₅₀ is 26.1 nM) and PDE4C2 (IC₅₀ is 271 nM). UK-500001 exhibits anti-inflammatory efficacy and inhibits TNF-α and IFN-γ release in human and rodent macrophagic cell lines in nanomolar levels. UK-500001 ameliorates chronic obstructive pulmonary disease (COPD) and asthma .

HY-N3945R

Glaucine (Standard)	Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus	Infection Inflammation/Immunology
Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .

HY-N3945

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Phosphodiesterase (PDE) Calcium Channel MMP NF-κB	Inflammation/Immunology Cancer
Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 (PDE4), with a K_i of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine inhibits the activation of NF-κB, leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer .

Cat. No.	Product Name	Target	Research Area

HY-P2424

Cholecystokinin-J CCK-J	Peptides	Others
Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca ²⁺ release .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122942

Moracin M	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Endogenous metabolite Inflammation/Immunology Disease Research Fields Morus alba Linn.	Phosphodiesterase (PDE) Endogenous Metabolite NF-κB Autophagy
Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent phosphodiesterase-4 (PDE4) inhibitor with IC₅₀ values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity .

HY-A0027

Fenspiride hydrochloride	Classification of Application Fields Disease Research Fields Endocrinology	Histamine Receptor Phosphodiesterase (PDE)
Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), *phosphodiesterase 4* (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC₅₀ values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases .

HY-N3945

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Infection Alkaloids Structural Classification other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Glaucium flavum Inflammation/Immunology Disease Research Fields Papaveraceae	Phosphodiesterase (PDE) Calcium Channel MMP NF-κB
Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 (PDE4), with a K_i of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine inhibits the activation of NF-κB, leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer .

HY-N2958

Braylin	Source classification Rutaceae Plants Zanthoxylum tingoassuiba A.St.-Hil.	Phosphodiesterase (PDE)
Braylin, a coumarin, is a potent phosphodiesterase-4 (PDE4) inhibitor and is involved in anti-inflammatory and immunomodulation, which may serve as a potential target for the study of immunoinflammatory diseases .

HY-N11431

ent-Toddalolactone	Toddalia asiatica (L.) Lam. Structural Classification Source classification Rutaceae Coumarins Phenylpropanoids Plants	Others
ent-Toddalolactone is a natural compound with anti-inflammatory and anticancer activities. Ent-Toddalolactone has shown inhibitory effects on phosphodiesterase-4 (PDE4) in vitro and is a potential drug target for inhibiting asthma and chronic obstructive pulmonary disease. The activity of ent-Toddalolactone is related to its unique chemical structure, and some of its derivatives showed IC₅₀ values below 10 μM in inhibition experiments, showing high biological activity .

HY-N10317

Toddacoumalone	Structural Classification other families Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Phosphodiesterase (PDE)
Toddacoumalone is a natural inhibitor of phosphodiesterase 4 (PDE4) with moderate potency and imperfect agent-like properties. Toddacoumalone has the potential for the research of inflammatory diseases such as psoriasis .

HY-121162

Mesembrine (+)-Mesembrine	Alkaloids other families Pyrrole Alkaloids Source classification Plants	5-HT Receptor Phosphodiesterase (PDE)
Mesembrine ((+)-Mesembrine) a main alkaloid that features an aryloctahydroindole skeleton. Mesembrine is a 5-HT transporter inhibitor with a K_i of 1.4 nM. Mesembrine also inhibits phosphodiesterase 4B (PDE4B) with an IC₅₀ of 7.8 μM .

HY-163777

Talaroterphenyl A	Structural Classification Monophenols Microorganisms Source classification Phenols	Phosphodiesterase (PDE)
Talaroterphenyl A (compound 1) is a p-terphenyl derivative present in the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41412, which exhibits phosphodiesterase 4 (PDE4) inhibitory activity (IC₅₀=1.2 μM). Talaroterphenyl A also exhibits anti-inflammatory and anti-fibrotic activities, significantly reducing the mRNA levels of pro-inflammatory cytokines IL-6, TNF-α, and IL-1β .

HY-N3945R

Glaucine (Standard)	Alkaloids Structural Classification other families Source classification Plants Isoquinoline Alkaloids Glaucium flavum Papaveraceae	Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus
Glaucine (Standard) is the analytical standard of Glaucine. This product is intended for research and analytical applications. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 μM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701961

	PDE4D Protein, Human (His) PDE4D; cAMP-specific 3'; 5'-cyclic Phosphodiesterase 4D; DPDE3; PDE43	Human	E. coli
	PDE4D (Phosphodiesterase 4D) protein, as a hydrolytic enzyme, degrades the second messenger cAMP, a crucial regulator in various physiological processes. Its enzymatic activity in breaking down cAMP underscores PDE4D's pivotal role in modulating cellular signaling cascades, maintaining the intricate balance of intracellular communication mediated by this critical second messenger. PDE4D Protein, Human (His) is the recombinant human-derived PDE4D protein, expressed by E. coli , with N-6*His labeled tag. The total length of PDE4D Protein, Human (His) is 328 a.a., .

HY-P701960

	PDE4D Protein, Human PDE4D; cAMP-specific 3'; 5'-cyclic Phosphodiesterase 4D; DPDE3; PDE43	Human	E. coli
	PDE4D (Phosphodiesterase 4D) protein, as a hydrolytic enzyme, degrades the second messenger cAMP, a crucial regulator in various physiological processes. Its enzymatic activity in breaking down cAMP underscores PDE4D's pivotal role in modulating cellular signaling cascades, maintaining the intricate balance of intracellular communication mediated by this critical second messenger. PDE4D Protein, Human is the recombinant human-derived PDE4D protein, expressed by E. coli , with tag free. The total length of PDE4D Protein, Human is 328 a.a., .

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Cat. No.	Product Name	Chemical Structure

HY-A0027AS

Fenspiride-d5

Fenspiride-d₅ is the deuterium labeled Fenspiride. Fenspiride, an orally active non-steroidal antiinflammatory agent, is an antagonist of H1-histamine receptor. Fenspiride inhibites phosphodiesterase 3 (PDE3), phosphodiesterase 4 (PDE4) and phosphodiesterase 5 (PDE5) activities with -log IC50 values of 3.44, 4.16 and approximately 3.8, respectively. Fenspiride can be used for the research of respiratory diseases[1][2][3].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83187

	PDE4B Antibody (YA2932) DPDE4; PDE 4B; PDE IVB; PDE32; Pde4b; PDE4B5; PDEIVB; Phosphodiesterase 4B	WB, FC	Human, Mouse
	PDE4B Antibody (YA2932) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2932), targeting PDE4B, with a predicted molecular weight of 83 kDa (observed band size: 95 kDa). PDE4B Antibody (YA2932) can be used for WB, FC experiment in human, mouse background.

HY-P81969

	PDE4D Antibody (YA1714) cAMP-specific 3' ; 5' -cyclic Phosphodiesterase 4D; DPDE3; PDE43; PDE4D; DPDE3	WB	Human
	PDE4D Antibody (YA1714) is a biotin-conjugated non-conjugated IgG antibody, targeting PDE4D, with a predicted molecular weight of 91 kDa (observed band size: 91 kDa). PDE4D Antibody (YA1714) can be used for WB experiment in human background.