UK-500001

Cat. No.: HY-119799: FAQs
Data Sheet Handling Instructions

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UK-500001 is an orally active inhibitor for phosphodiesterase 4 (PDE4), which inhibits PDE4D3 (IC₅₀ is 0.28 nM), PDE4B2 (IC₅₀ is 22.8 nM), PDE4A4 (IC₅₀ is 26.1 nM) and PDE4C2 (IC₅₀ is 271 nM). UK-500001 exhibits anti-inflammatory efficacy and inhibits TNF-α and IFN-γ release in human and rodent macrophagic cell lines in nanomolar levels. UK-500001 ameliorates chronic obstructive pulmonary disease (COPD) and asthma.

For research use only. We do not sell to patients.

UK-500001 Chemical Structure

CAS No. : 582332-31-8

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•Related Small Molecules:

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View All Isoforms

PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

PDE4D3

0.28 nM (IC₅₀)

PDE4B2

22.8 nM (IC₅₀)

PDE4A4

26.1 nM (IC₅₀)

PDE4C2

217 nM (IC₅₀)

Molecular Weight

499.48

Formula

C₂₆H₂₄F₃N₃O₄

CAS No.

582332-31-8

SMILES

O=C(C1=C(C=CC(C)=C1)O)N[C@H](CC2)CC[C@H]2NC(C(C=C(F)C=N3)=C3OC4=CC(F)=C(F)C=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Moretto N, et al., CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration. J Pharmacol Exp Ther. 2015 Mar;352(3):559-67. [Content Brief]

UK-500001 Related Classifications

Inflammation/Immunology

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UK-500001582332-31-8UK500001UK 500001Phosphodiesterase (PDE)THP-1NR8383RAW264.7PBMCchronic obstructive pulmonary diseaseasthmaCOPDorally activeInhibitorinhibitorinhibit

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