2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Lirimilast

Lirimilast  (Synonyms: BAY 19-8004)

Cat. No.: HY-19672 Purity: 98.69%
COA Handling Instructions

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Lirimilast (BAY 19-8004) is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 49 nM. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease (COPD). Lirimilast has potently anti-inflammatory properties.

For research use only. We do not sell to patients.

Lirimilast Chemical Structure

Lirimilast Chemical Structure

CAS No. : 329306-27-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 616 In-stock
Solution
10 mM * 1 mL in DMSO USD 616 In-stock
Solid
1 mg USD 224 In-stock
5 mg USD 560 In-stock
10 mg USD 950 In-stock
25 mg USD 1710 In-stock
50 mg USD 2565 In-stock
100 mg USD 3848 In-stock
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Based on 1 publication(s) in Google Scholar

Lirimilast Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Lirimilast (BAY 19-8004) is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 49 nM. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease (COPD). Lirimilast has potently anti-inflammatory properties[1][2].

IC50 & Target

PDE4

42 nM (IC50)

In Vitro

In PDE4 assays Lirimilast (BAY 19-8004) is reported to be 5-fold more potent than Cilomilast and equipotent with CDP-840 using freshly prepared PDE4 from human PMNL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lirimilast Related Antibodies
In Vivo

Since Lirimilast (BAY 19-8004) is orally active in the guinea-pig at 3 mg/kg and, more critically, in primates at 0.1 mg/kg/day it appears to have a good therapeutic ratio. In addition Lirimilast is found to be 3-fold more potent than Cilomilast when compared in a rat model of lung neutrophilic inflammation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

443.26

Formula

C17H12Cl2N2O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N)NC1=C(C(C2=CC=C(Cl)C=C2Cl)=O)OC3=CC(OS(=O)(C)=O)=CC=C13
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (225.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2560 mL 11.2801 mL 22.5601 mL
5 mM 0.4512 mL 2.2560 mL 4.5120 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.69%

COA (256 KB) HNMR (143 KB) RP-HPLC (168 KB) LCMS (100 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2560 mL 11.2801 mL 22.5601 mL 56.4003 mL
5 mM 0.4512 mL 2.2560 mL 4.5120 mL 11.2801 mL
10 mM 0.2256 mL 1.1280 mL 2.2560 mL 5.6400 mL
15 mM 0.1504 mL 0.7520 mL 1.5040 mL 3.7600 mL
20 mM 0.1128 mL 0.5640 mL 1.1280 mL 2.8200 mL
25 mM 0.0902 mL 0.4512 mL 0.9024 mL 2.2560 mL
30 mM 0.0752 mL 0.3760 mL 0.7520 mL 1.8800 mL
40 mM 0.0564 mL 0.2820 mL 0.5640 mL 1.4100 mL
50 mM 0.0451 mL 0.2256 mL 0.4512 mL 1.1280 mL
60 mM 0.0376 mL 0.1880 mL 0.3760 mL 0.9400 mL
80 mM 0.0282 mL 0.1410 mL 0.2820 mL 0.7050 mL
100 mM 0.0226 mL 0.1128 mL 0.2256 mL 0.5640 mL
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Lirimilast Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lirimilast329306-27-6BAY 19-8004Phosphodiesterase (PDE)Anti-inflammatoryasthmaCOPDPDE4orallyInhibitorinhibitorinhibit

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