1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Tanimilast

Tanimilast (CHF-6001) is a novel highly potent and selective phosphodiesterase 4 inhibitor(IC50=0.026 ± 0.006 nM) with robust anti-inflammatory activity and suitable for topical pulmonary administration.Tanimilast is used for the research of obstructive lung diseases.

For research use only. We do not sell to patients.

Tanimilast Chemical Structure

Tanimilast Chemical Structure

CAS No. : 1239278-59-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
1 mg In-stock
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

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Description

Tanimilast (CHF-6001) is a novel highly potent and selective phosphodiesterase 4 inhibitor(IC50=0.026 ± 0.006 nM) with robust anti-inflammatory activity and suitable for topical pulmonary administration.Tanimilast is used for the research of obstructive lung diseases[1].

Cellular Effect
Cell Line Type Value Description References
U-937 IC50
0.04 nM
Compound: (S)-32a
Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay
Inhibition of PDE4 isolated from human U937 cells assessed as reduction in cAMP level by LANCE assay
[PMID: 24400806]
Molecular Weight

687.54

Formula

C30H30Cl2F2N2O8S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[C@H](C1=CC=C(OC(F)F)C(OCC2CC2)=C1)CC3=C(Cl)C=[N+]([O-])C=C3Cl)C4=CC=C(NS(=O)(C)=O)C(OCC5CC5)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (290.89 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4545 mL 7.2723 mL 14.5446 mL
5 mM 0.2909 mL 1.4545 mL 2.9089 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4545 mL 7.2723 mL 14.5446 mL 36.3615 mL
5 mM 0.2909 mL 1.4545 mL 2.9089 mL 7.2723 mL
10 mM 0.1454 mL 0.7272 mL 1.4545 mL 3.6362 mL
15 mM 0.0970 mL 0.4848 mL 0.9696 mL 2.4241 mL
20 mM 0.0727 mL 0.3636 mL 0.7272 mL 1.8181 mL
25 mM 0.0582 mL 0.2909 mL 0.5818 mL 1.4545 mL
30 mM 0.0485 mL 0.2424 mL 0.4848 mL 1.2121 mL
40 mM 0.0364 mL 0.1818 mL 0.3636 mL 0.9090 mL
50 mM 0.0291 mL 0.1454 mL 0.2909 mL 0.7272 mL
60 mM 0.0242 mL 0.1212 mL 0.2424 mL 0.6060 mL
80 mM 0.0182 mL 0.0909 mL 0.1818 mL 0.4545 mL
100 mM 0.0145 mL 0.0727 mL 0.1454 mL 0.3636 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tanimilast
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HY-19929
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