2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Dovramilast

Dovramilast  (Synonyms: CC-11050)

Cat. No.: HY-147263 Purity: 99.83%
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Dovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor and can reduce the inflammatory response and improves Isoniazid (INH)-mediated bacillary clearance from the lungs. Dovramilast, as an adjunct, is used for the research of tuberculosis (TB).

For research use only. We do not sell to patients.

Dovramilast Chemical Structure

Dovramilast Chemical Structure

CAS No. : 340019-69-4

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5 mg USD 380 In-stock
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100 mg USD 2850 In-stock
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Based on 1 publication(s) in Google Scholar

Dovramilast Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

Dovramilast (CC-11050) is an orally active phosphodiesterase 4 (PDE4) inhibitor and can reduce the inflammatory response and improves Isoniazid (INH)-mediated bacillary clearance from the lungs. Dovramilast, as an adjunct, is used for the research of tuberculosis (TB)[1].

IC50 & Target

PDE4

 

In Vivo

Dovramilast (oral gavage, 5, 25, or 50 mg/kg, single) significantly improves antibiotic-mediated bacterial killing and reduces lung pathology[2].
Pharmacokinetic Parameters of Dovramilast in B6D2F1 mice[2].

Sampling time(h) Concentration(ng/ml)
CC-11050 only CC-11050+INH
1 1,331.6±136.97 905.35±594.23
2 1,409.47±140.85 1,309.39±214.08
5 948.85±128.7 1,609.18±167.2
8 820.6±265.98 1,271.73±249.18
24 1.27±1.1 4.96±1.85
Tmax(h) 2.0 5.0
Cmax(ng/ml) 1,410 1,610
AUClast(ng × h/ml) 10,200 13,900

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B6D2F1 mice[2]
Dosage: 5, 25, or 50 mg/kg
Administration: oral, 5, 25, or 50 mg/kg, single
Result: Reduced PDE4 expression in mtb-infected mouse lungs.
Animal Model: B6D2F1 mice[2]
Dosage: 5, 25, or 50 mg/kg
Administration: oral gavage, 5, 25, or 50 mg/kg, single
Result: Improved antibiotic-mediated bacterial killing and reduced lung pathology.
Clinical Trial
Molecular Weight

472.55

Formula

C24H28N2O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1CC1)NC2=CC=CC(CN3[C@@H](C4=CC=C(OC)C(OCC)=C4)CS(=O)(C)=O)=C2C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (52.90 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1162 mL 10.5809 mL 21.1618 mL
5 mM 0.4232 mL 2.1162 mL 4.2324 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1162 mL 10.5809 mL 21.1618 mL 52.9045 mL
5 mM 0.4232 mL 2.1162 mL 4.2324 mL 10.5809 mL
10 mM 0.2116 mL 1.0581 mL 2.1162 mL 5.2904 mL
15 mM 0.1411 mL 0.7054 mL 1.4108 mL 3.5270 mL
20 mM 0.1058 mL 0.5290 mL 1.0581 mL 2.6452 mL
25 mM 0.0846 mL 0.4232 mL 0.8465 mL 2.1162 mL
30 mM 0.0705 mL 0.3527 mL 0.7054 mL 1.7635 mL
40 mM 0.0529 mL 0.2645 mL 0.5290 mL 1.3226 mL
50 mM 0.0423 mL 0.2116 mL 0.4232 mL 1.0581 mL
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Dovramilast Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dovramilast340019-69-4CC-11050CC11050CC 11050Phosphodiesterase (PDE)phosphodiesterase 4 (PDE4)inflammatoryINHTNForalInhibitorinhibitorinhibit

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