LEO 29102

Cat. No.: HY-12348: FAQs
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LEO 29102 is a potent phosphodiesterase 4 (PDE4) inhibitor with an IC₅₀ value of 5 nM. LEO 29102 inhibits TNFα release. LEO 29102 has the potential for the research of atopic dermatitis.

For research use only. We do not sell to patients.

LEO 29102 Chemical Structure

CAS No. : 1035572-38-3

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Biological Activity
Purity & Documentation
References
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Description

LEO 29102 is a potent phosphodiesterase 4 (PDE4) inhibitor with an IC₅₀ value of 5 nM. LEO 29102 inhibits TNFα release. LEO 29102 has the potential for the research of atopic dermatitis^[1].

IC₅₀ & Target^[1]

PDE4

5 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
PBMC	IC₅₀	16 nM Compound: 20	Inhibition of LPS-induced TNFalpha release in human PBMC preincubated for 30 mins before LPS stimulation measured after 18 hrs by TR-FRET assay Inhibition of LPS-induced TNFalpha release in human PBMC preincubated for 30 mins before LPS stimulation measured after 18 hrs by TR-FRET assay	[PMID: 24984230]

Molecular Weight

441.31

Formula

C₂₀H₂₂Cl₂N₂O₅

CAS No.

1035572-38-3

SMILES

COC1=C(C=CC(C(CC2=C(C=NC=C2Cl)Cl)=O)=C1OCC(NCCC)=O)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Felding J, et al. Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis. J Med Chem. 2014 Jul 24;57(14):5893-903. [Content Brief]

LEO 29102 Related Classifications

Inflammation/Immunology

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LEO 291021035572-38-3LEO29102LEO-29102Phosphodiesterase (PDE)TNFαatopic dermatitisInhibitorinhibitorinhibit

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