Denbufylline (Synonyms: BRL 30892)

Cat. No.: HY-130786 Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Denbufylline (BRL 30892) is an inhibitor of phosphodiesterase-4 (PDE4). Denbufylline is able to block the degradation of intracellular cAMP (cyclic adenosine phosphate) thereby increasing the level of intracellular cAMP, which helps regulate a variety of cellular functions. Denbufylline can be used in the study of chronic obstructive pulmonary disease (COPD), asthma and other inflammatory diseases.

For research use only. We do not sell to patients.

Denbufylline Chemical Structure

CAS No. : 57076-71-8

Size	Price	Stock	Quantity
5 mg	USD 370	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

320.39

Formula

C₁₆H₂₄N₄O₃

CAS No.

57076-71-8

Appearance

Solid

Color

White to light yellow

SMILES

O=C(N1CCCC)N(CCCC)C2=C(N(CC(C)=O)C=N2)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 33 mg/mL (103.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1212 mL	15.6060 mL	31.2120 mL
5 mM	0.6242 mL	3.1212 mL	6.2424 mL
10 mM	0.3121 mL	1.5606 mL	3.1212 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (250 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)

References

[1]. Martin L, et al. Sustained buccal delivery of the hydrophobic drug denbufylline using physically cross-linked palmitoyl glycol chitosan hydrogels[J]. European journal of pharmaceutics and biopharmaceutics, 2003, 55(1): 35-45. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1212 mL	15.6060 mL	31.2120 mL	78.0299 mL
	5 mM	0.6242 mL	3.1212 mL	6.2424 mL	15.6060 mL
	10 mM	0.3121 mL	1.5606 mL	3.1212 mL	7.8030 mL
	15 mM	0.2081 mL	1.0404 mL	2.0808 mL	5.2020 mL
	20 mM	0.1561 mL	0.7803 mL	1.5606 mL	3.9015 mL
	25 mM	0.1248 mL	0.6242 mL	1.2485 mL	3.1212 mL
	30 mM	0.1040 mL	0.5202 mL	1.0404 mL	2.6010 mL
	40 mM	0.0780 mL	0.3901 mL	0.7803 mL	1.9507 mL
	50 mM	0.0624 mL	0.3121 mL	0.6242 mL	1.5606 mL
	60 mM	0.0520 mL	0.2601 mL	0.5202 mL	1.3005 mL
	80 mM	0.0390 mL	0.1951 mL	0.3901 mL	0.9754 mL
	100 mM	0.0312 mL	0.1561 mL	0.3121 mL	0.7803 mL

Denbufylline Related Classifications

Inflammation/Immunology Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Denbufylline57076-71-8BRL 30892BRL30892BRL-30892Phosphodiesterase (PDE)Xanthine derivativesinhibitorsPDE4cAMPneuroprotective agentsInhibitorinhibitorinhibit

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