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S-adenosyl-L-methionine

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (4) DNA Methyltransferase (2) Endogenous Metabolite (7) Histone Methyltransferase (3) Influenza Virus (1) Isotope-Labeled Compounds (2)
By Research Areas:	Cancer (12) Infection (1) Inflammation/Immunology (4) Metabolic Disease (1) Neurological Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Methionine Adenosyltransferase (MAT) MetAP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W017770

S-Adenosyl-L-methionine disulfate tosylate 10+ Cited Publications Ademetionine disulfate tosylate; S-adenosyl methionine disulfate tosylate; AdoMet disulfate tosylate	Endogenous Metabolite Apoptosis	Neurological Disease Cancer
S-Adenosyl-L-methionine disulfate tosylate is the disulfate tosylate form of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .

HY-B0617A

S-Adenosyl-L-methionine tosylate 10+ Cited Publications S-adenosyl methionine tosylate; Ademetionine tosylate; AdoMet tosylate	Endogenous Metabolite Apoptosis	Neurological Disease Inflammation/Immunology Cancer
S-Adenosyl-L-methionine tosylate is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research .

HY-B0617S

S-Adenosyl-L-methionine-d3 S-adenosyl methionine-d₃; Ademetionine-d₃; AdoMet-d₃	Endogenous Metabolite	Neurological Disease Inflammation/Immunology Cancer
S-Adenosyl-L-methionine-d₃ is the deuterated product of S-Adenosyl-L-methionine. S-Adenosyl-L-methionine is endogenously produced from methionine and ATP through the action of methionine adenosyltransferase and is an important orally active methyl donor .

HY-14614A

S-Adenosyl-L-methionine chloride dihydrochloride 10+ Cited Publications S-adenosyl methionine chloride dihydrochloride; Ademetionine chloride dihydrochloride; AdoMet chloride dihydrochloride	Others	Others
S-(5'-Adenosyl)-L-methionine chloride dihydrochloride is a methyl donor and cofactor.

HY-150964S

*(RS)-S-Adenosyl-L-methionine-d3 (tetra-toluenesulfonate)*	Isotope-Labeled Compounds	Others
(RS)-S-Adenosyl-L-methionine-d3 (tetra-toluenesulfonate) is the deuterium labeled (RS)-S-Adenosyl-L-methionine tetra-toluenesulfonate[1].

HY-B0617

**S-Adenosyl-L-methionine** S-adenosyl methionine; Ademetionine; AdoMet	Endogenous Metabolite Apoptosis	Neurological Disease Inflammation/Immunology Cancer
S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .

HY-14614D

S-Adenosyl-L-methionine iodide S-adenosyl methionine iodide; Ademetionine iodide; AdoMet iodide	Endogenous Metabolite	Metabolic Disease Cancer
S-(5'-Adenosyl)-L-methionine iodide (S-Adenosyl-L-methionine iodide) is an important methyl donor that is found in all living organisms .

HY-B0617B

S-Adenosyl-L-methionine (1,4-butanedisulfonate) S-adenosyl methionine (1,4-butanedisulfonate); Ademetionine (1,4-butanedisulfonate); AdoMet (1,4-butanedisulfonate)	Endogenous Metabolite Apoptosis	Neurological Disease Inflammation/Immunology Cancer
S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate is an orally active methyl group donor. S-Adenosyl-L-methionine 1,4-butanedisulfonate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine 1,4-butanedisulfonate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine 1,4-butanedisulfonate has the potential for, cancer, liver disease and osteoarthritis research .

HY-B0617S1

S-Adenosyl-L-methionine-13C S-adenosyl methionine-¹³C; Ademetionine-¹³C; AdoMet--¹³C	Endogenous Metabolite	Cancer
S-Adenosyl-L-methionine- ¹³C is the ¹³C labeled S-Adenosyl-L-methionine[1]. S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects, and has the potential for liver disease and osteoarthritis research[2][3][4].

HY-150849S

*(RS)-S-Adenosyl-L-methionine-d3 (S-methyl-d3) Tetra(p-toluenesulfonate) Salt*	Isotope-Labeled Compounds	Others
(RS)-S-Adenosyl-L-methionine-d₃(S-methyl-d₃) Tetra(p-toluenesulfonate) Salt is the deuterium labeled (RS)-S-Adenosyl-L-methionine Tetra(p-toluenesulfonate) Salt[1].

HY-156048

Trifluoromethyl-tubercidin TFMT	Influenza Virus	Infection
Trifluoromethyl-tubercidin (TFMT) is a 2'-O-ribose methyltransferase 1 (MTr1) inhibitor through interaction at its S-adenosyl-l-methionine binding pocket to restrict influenza virus replication .

HY-E70209

EcoRI Methyltransferase	DNA Methyltransferase	Cancer
EcoRI Methyltransferase is a bacterial sequence-specific S-adenosyl-L-methionine-dependent DNA methyltransferase. EcoRI Methyltransferase relies on a complex conformational mechanism to achieve its remarkable specificity, including DNA bending, base flipping and intercalation into the DNA .

HY-126126

**S-Adenosyl-DL-methionine**	Others	Others
S-Adenosyl-DL-methionine is a derivative of Ademetionine (HY-B0617). Ademetionine is an intermediate metabolite of methionine .

HY-128717

GSK3368715 EPZ019997	Histone Methyltransferase	Cancer
GSK3368715 (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

HY-128717A

GSK3368715 dihydrochloride Maximum Cited Publications 13 Publications Verification EPZ019997 dihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

HY-128717B

GSK3368715 trihydrochloride EPZ019997 trihydrochloride	Histone Methyltransferase	Cancer
GSK3368715 trihydrochloride (EPZ019997) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC₅₀=3.1 nM (PRMT1), 48 nM (PRMT3), 1148 nM (PRMT4), 5.7 nM (PRMT6), 1.7 nM (PRMT8)). GSK3368715 trihydrochloride (EPZ019997) produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity .

HY-161694

DNMT1-IN-3	DNA Methyltransferase	Cancer
DNMT1-IN-3 (compound 7t-S) is an effective DNA methyltransferase 1 (DNMT1) inhibitor with an IC₅₀ value of 0.777 μM and a K_D value of 0.183 μM. DNMT1-IN-3 can bind to the methyl donor S-adenosyl-l-methionine (SAM) site in DNMT1. DNMT1-IN-3 can inhibit cell proliferation in K562 cells by inducing cells apoptosis and arresting cell cycle at G0 / G1 phase, which has the potential to be used for the research of hematologic tumor .

Cat. No.	Product Name	Type

HY-B0617

**S-Adenosyl-L-methionine** S-adenosyl methionine; Ademetionine; AdoMet	Biochemical Assay Reagents
S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .

S-Adenosyl-L-methionine

S-adenosyl methionine; Ademetionine; AdoMet

Biochemical Assay Reagents

S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .

Cat. No.	Product Name	Target	Research Area

HY-14614D

S-Adenosyl-L-methionine iodide S-adenosyl methionine iodide; Ademetionine iodide; AdoMet iodide	Endogenous Metabolite	Metabolic Disease Cancer
S-(5'-Adenosyl)-L-methionine iodide (S-Adenosyl-L-methionine iodide) is an important methyl donor that is found in all living organisms .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W017770

S-Adenosyl-L-methionine disulfate tosylate Maximum Cited Publications 11 Publications Verification Ademetionine disulfate tosylate; S-adenosyl methionine disulfate tosylate; AdoMet disulfate tosylate	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite Apoptosis
S-Adenosyl-L-methionine disulfate tosylate is the disulfate tosylate form of S-Adenosyl-L-methionine (HY-B0617). S-Adenosyl-L-methionine is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .

HY-B0617A

S-Adenosyl-L-methionine tosylate Maximum Cited Publications 11 Publications Verification S-adenosyl methionine tosylate; Ademetionine tosylate; AdoMet tosylate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Apoptosis
S-Adenosyl-L-methionine tosylate is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine tosylate is a dietary supplement with potent antidepressant and analgesic effects, and has the potential for liver disease and osteoarthritis research .

HY-B0617

**S-Adenosyl-L-methionine** S-adenosyl methionine; Ademetionine; AdoMet	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Apoptosis
S-Adenosyl-L-methionine (S-Adenosyl methionine) is an orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine has the potential for, cancer, liver disease and osteoarthritis research .

HY-14614D

S-Adenosyl-L-methionine iodide S-adenosyl methionine iodide; Ademetionine iodide; AdoMet iodide	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
S-(5'-Adenosyl)-L-methionine iodide (S-Adenosyl-L-methionine iodide) is an important methyl donor that is found in all living organisms .

HY-B0617B

S-Adenosyl-L-methionine (1,4-butanedisulfonate) S-adenosyl methionine (1,4-butanedisulfonate); Ademetionine (1,4-butanedisulfonate); AdoMet (1,4-butanedisulfonate)	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate is an orally active methyl group donor. S-Adenosyl-L-methionine 1,4-butanedisulfonate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine 1,4-butanedisulfonate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine 1,4-butanedisulfonate has the potential for, cancer, liver disease and osteoarthritis research .

HY-126126

**S-Adenosyl-DL-methionine**	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Others
S-Adenosyl-DL-methionine is a derivative of Ademetionine (HY-B0617). Ademetionine is an intermediate metabolite of methionine .

Cat. No.	Product Name	Chemical Structure

HY-B0617S

S-Adenosyl-L-methionine-d3
S-Adenosyl-L-methionine-d₃ is the deuterated product of S-Adenosyl-L-methionine. S-Adenosyl-L-methionine is endogenously produced from methionine and ATP through the action of methionine adenosyltransferase and is an important orally active methyl donor .

HY-150964S

*(RS)-S-Adenosyl-L-methionine-d3 (tetra-toluenesulfonate)*
(RS)-S-Adenosyl-L-methionine-d3 (tetra-toluenesulfonate) is the deuterium labeled (RS)-S-Adenosyl-L-methionine tetra-toluenesulfonate[1].

HY-B0617S1

S-Adenosyl-L-methionine-13C
S-Adenosyl-L-methionine- ¹³C is the ¹³C labeled S-Adenosyl-L-methionine[1]. S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects, and has the potential for liver disease and osteoarthritis research[2][3][4].

S-Adenosyl-L-methionine-13C

S-Adenosyl-L-methionine- ¹³C is the ¹³C labeled S-Adenosyl-L-methionine[1]. S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects, and has the potential for liver disease and osteoarthritis research[2][3][4].

HY-150849S

*(RS)-S-Adenosyl-L-methionine-d3 (S-methyl-d3) Tetra(p-toluenesulfonate) Salt*
(RS)-S-Adenosyl-L-methionine-d₃(S-methyl-d₃) Tetra(p-toluenesulfonate) Salt is the deuterium labeled (RS)-S-Adenosyl-L-methionine Tetra(p-toluenesulfonate) Salt[1].

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S-adenosyl-L-methionine

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products