S-Adenosyl-L-methionine (1,4-butanedisulfonate) (Synonyms: S-Adenosyl methionine (1,4-butanedisulfonate); Ademetionine (1,4-butanedisulfonate); AdoMet (1,4-butanedisulfonate))

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S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate is an orally active methyl group donor. S-Adenosyl-L-methionine 1,4-butanedisulfonate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine 1,4-butanedisulfonate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine 1,4-butanedisulfonate has the potential for, cancer, liver disease and osteoarthritis research.

For research use only. We do not sell to patients.

S-Adenosyl-L-methionine (1,4-butanedisulfonate) Chemical Structure

CAS No. : 200393-05-1

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Other In-stock Forms of S-Adenosyl-L-methionine (1,4-butanedisulfonate):

S-Adenosyl-L-methionine S-Adenosyl-L-methionine disulfate tosylate

Other Forms of S-Adenosyl-L-methionine (1,4-butanedisulfonate):

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11 Publications Citing Use of MCE S-Adenosyl-L-methionine (1,4-butanedisulfonate)

: S-Adenosyl-L-methionine (1,4-butanedisulfonate) purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2021 Mar 22;95:107545. [Abstract]; S-adenosylmethionine (SAMe) application at 30 min prior to high glucose treatment significantly increased H2S levels compared with the HG group. The cystathionine-β-synthase (CBS) level is obviously elevated in HG + SAMe group compared with the HG group.

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Description

In Vitro

S-Adenosyl-L-methionine (300 µM, 24 or 48 h) 1,4-butanedisulfonate induces cell apoptosis, and promotes the cell cycle arrest in Cal-33 and JHU-SCC-011 cells^[4].
S-Adenosyl-L-methionine (300 µM, 24 h) 1,4-butanedisulfonate decreases the migration of the Cal-33 and JHU-SCC-011 cells^[4].
S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) 1,4-butanedisulfonate protects the anticancer effect of 5‑FU by regulating the expression of DNMTs^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[4]

Cell Line:	Cal-33 and JHU-SCC-011 cells
Concentration:	300 µM
Incubation Time:	24 h (Cal-33) or 48 h (HU-SCC-011)
Result:	Showed an approximately 10% and 3%of apoptotic cells respectively.

Cell Cycle Analysis^[4]

Cell Line:	Cal-33 and JHU-SCC-011 cells
Concentration:	300 µM
Incubation Time:	24 h (Cal-33) or 48 h (HU-SCC-011)
Result:	Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.

In Vivo

S-Adenosyl-L-methionine (30 mg/kg, p.o., for 3 days) 1,4-butanedisulfonate prevents ASD like behaviors induced by early postnatal valproic acid exposure in young mice^[6].
S-Adenosyl-L-methionine (50 and 100 mg/kg, p.o.) 1,4-butanedisulfonate shows antiepileptic, memory-enhancing, and antioxidant properties in a Pentylenetetrazole-induced rat epilepsy model^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Valproic acid treated young mice^[6]
Dosage:	30 mg/kg
Administration:	p.o., for 3 days
Result:	Alleviated most ASD like neurobehavioral symptoms. Normalized the redox potential in the prefrontal cortex.

Molecular Weight

616.69

Formula

C₁₉H₃₂N₆O₁₁S₃

CAS No.

200393-05-1

SMILES

O=S(CCCCS(=O)(O)=O)(O)=O.O[C@H]1[C@@H](O[C@@H]([C@H]1O)C[S+](C)CC[C@H](N)C([O-])=O)N2C3=NC=NC(N)=C3N=C2

Structure Classification

Others

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14. [Content Brief]

[2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6. [Content Brief]

[3]. Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42. [Content Brief]

[4]. Mosca L, et al. Effects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. Int J Oncol. 2020 May;56(5):1212-1224. [Content Brief]

[5]. Ham MS, et al. S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells. Mol Clin Oncol. 2013 Mar;1(2):373-378. [Content Brief]

[6]. Ornoy A, et al. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicol Teratol. 2019 Jan-Feb;71:64-74. [Content Brief]

[7]. Dhediya RM, et al. Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats. Epilepsy Behav. 2016 Aug;61:153-157. [Content Brief]

S-Adenosyl-L-methionine (1,4-butanedisulfonate) Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-Adenosyl-L-methionine (1,4-butanedisulfonate)200393-05-1S-Adenosyl methionine (1,4-butanedisulfonate) Ademetionine (1,4-butanedisulfonate) AdoMet (1,4-butanedisulfonate)Endogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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