2. Metabolic Enzyme/Protease Apoptosis
  3. Endogenous Metabolite Apoptosis
  4. S-Adenosyl-L-methionine (1,4-butanedisulfonate)

S-Adenosyl-L-methionine (1,4-butanedisulfonate)  (Synonyms: S-Adenosyl methionine (1,4-butanedisulfonate); Ademetionine (1,4-butanedisulfonate); AdoMet (1,4-butanedisulfonate))

Cat. No.: HY-B0617B
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S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate is an orally active methyl group donor. S-Adenosyl-L-methionine 1,4-butanedisulfonate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine 1,4-butanedisulfonate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine 1,4-butanedisulfonate has the potential for, cancer, liver disease and osteoarthritis research.

For research use only. We do not sell to patients.

S-Adenosyl-L-methionine (1,4-butanedisulfonate) Chemical Structure

S-Adenosyl-L-methionine (1,4-butanedisulfonate) Chemical Structure

CAS No. : 200393-05-1

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S-Adenosyl-L-methionine (1,4-butanedisulfonate) Related Antibodies

Top Publications Citing Use of Products

    S-Adenosyl-L-methionine (1,4-butanedisulfonate) purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2021 Mar 22;95:107545.  [Abstract]

    S-adenosylmethionine (SAMe) application at 30 min prior to high glucose treatment significantly increased H2S levels compared with the HG group. The cystathionine-β-synthase (CBS) level is obviously elevated in HG + SAMe group compared with the HG group.

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    Description

    S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate is an orally active methyl group donor. S-Adenosyl-L-methionine 1,4-butanedisulfonate is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine 1,4-butanedisulfonate also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine 1,4-butanedisulfonate has the potential for, cancer, liver disease and osteoarthritis research[1][2][3].

    In Vitro

    S-Adenosyl-L-methionine (300 µM, 24 or 48 h) 1,4-butanedisulfonate induces cell apoptosis, and promotes the cell cycle arrest in Cal-33 and JHU-SCC-011 cells[4].
    S-Adenosyl-L-methionine (300 µM, 24 h) 1,4-butanedisulfonate decreases the migration of the Cal-33 and JHU-SCC-011 cells[4].
    S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) 1,4-butanedisulfonate protects the anticancer effect of 5‑FU by regulating the expression of DNMTs[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    S-Adenosyl-L-methionine (1,4-butanedisulfonate) Related Antibodies

    Apoptosis Analysis[4]

    Cell Line: Cal-33 and JHU-SCC-011 cells
    Concentration: 300 µM
    Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
    Result: Showed an approximately 10% and 3%of apoptotic cells respectively.

    Cell Cycle Analysis[4]

    Cell Line: Cal-33 and JHU-SCC-011 cells
    Concentration: 300 µM
    Incubation Time: 24 h (Cal-33) or 48 h (HU-SCC-011)
    Result: Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.
    In Vivo

    S-Adenosyl-L-methionine (30 mg/kg, p.o., for 3 days) 1,4-butanedisulfonate prevents ASD like behaviors induced by early postnatal valproic acid exposure in young mice[6].
    S-Adenosyl-L-methionine (50 and 100 mg/kg, p.o.) 1,4-butanedisulfonate shows antiepileptic, memory-enhancing, and antioxidant properties in a Pentylenetetrazole-induced rat epilepsy model[7].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Valproic acid treated young mice[6]
    Dosage: 30 mg/kg
    Administration: p.o., for 3 days
    Result: Alleviated most ASD like neurobehavioral symptoms.
    Normalized the redox potential in the prefrontal cortex.
    Molecular Weight

    616.69

    Formula

    C19H32N6O11S3
    CAS No.
    SMILES

    O=S(CCCCS(=O)(O)=O)(O)=O.O[C@H]1[C@@H](O[C@@H]([C@H]1O)C[S+](C)CC[C@H](N)C([O-])=O)N2C3=NC=NC(N)=C3N=C2
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    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
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    S-Adenosyl-L-methionine (1,4-butanedisulfonate) Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    S-Adenosyl-L-methionine (1,4-butanedisulfonate)200393-05-1S-Adenosyl methionine (1,4-butanedisulfonate) Ademetionine (1,4-butanedisulfonate) AdoMet (1,4-butanedisulfonate)Endogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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