S-Adenosyl-DL-methionine

Cat. No.: HY-126126: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

S-Adenosyl-DL-methionine is a derivative of Ademetionine (HY-B0617). Ademetionine is an intermediate metabolite of methionine.

For research use only. We do not sell to patients.

S-Adenosyl-DL-methionine Chemical Structure

CAS No. : 17176-17-9

Size	Price	Stock
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 55	Ask For Quote & Lead Time
Solution
10 mM * 1 mL in Water	USD 55	Ask For Quote & Lead Time
Solid
5 mg	USD 50	Ask For Quote & Lead Time
10 mg	USD 80	Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of S-Adenosyl-DL-methionine:

S-Adenosyl-L-methionine tosylate Get quote

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

S-Adenosyl-DL-methionine is a derivative of Ademetionine (HY-B0617). Ademetionine is an intermediate metabolite of methionine^[1].

Molecular Weight

398.44

Formula

C₁₅H₂₂N₆O₅S

CAS No.

17176-17-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3C[S+](CCC(N)C([O-])=O)C

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 250 mg/mL (627.45 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5098 mL	12.5489 mL	25.0979 mL
5 mM	0.5020 mL	2.5098 mL	5.0196 mL
10 mM	0.2510 mL	1.2549 mL	2.5098 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.84%

Select Batch:

Data Sheet (270 KB) SDS (251 KB)

COA (247 KB) HNMR (285 KB) LCMS (269 KB)

Handling Instructions (2659 KB)

References

[1]. Liu, W., et al. Efficient production of S-adenosyl-L-methionine from DL-methionine in metabolic engineered Saccharomyces cerevisiae. Biotechnology and Bioengineering. 2019. 177, 170-175.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.5098 mL	12.5489 mL	25.0979 mL	62.7447 mL
	5 mM	0.5020 mL	2.5098 mL	5.0196 mL	12.5489 mL
	10 mM	0.2510 mL	1.2549 mL	2.5098 mL	6.2745 mL
	15 mM	0.1673 mL	0.8366 mL	1.6732 mL	4.1830 mL
	20 mM	0.1255 mL	0.6274 mL	1.2549 mL	3.1372 mL
	25 mM	0.1004 mL	0.5020 mL	1.0039 mL	2.5098 mL
	30 mM	0.0837 mL	0.4183 mL	0.8366 mL	2.0915 mL
	40 mM	0.0627 mL	0.3137 mL	0.6274 mL	1.5686 mL
	50 mM	0.0502 mL	0.2510 mL	0.5020 mL	1.2549 mL
	60 mM	0.0418 mL	0.2091 mL	0.4183 mL	1.0457 mL
	80 mM	0.0314 mL	0.1569 mL	0.3137 mL	0.7843 mL
	100 mM	0.0251 mL	0.1255 mL	0.2510 mL	0.6274 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.