(RS)-S-Adenosyl-L-methionine-d₃ (tetra-toluenesulfonate) 

(RS)-S-Adenosyl-L-methionine-d3 (tetra-toluenesulfonate) is the deuterium labeled (RS)-S-Adenosyl-L-methionine tetra-toluenesulfonate[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1090.26

C₄₃H₅₁D₃N₆O₁₇S₅

Solid

White to off-white

O[C@H]1[C@](O[C@@H]([C@H]1O)C[S+](C([2H])([2H])[2H])CC[C@H](N)C(O)=O)([H])N2C3=NC=NC(N)=C3N=C2.O=S([O-])(C4=CC=C(C=C4)C)=O.O=S(O)(C5=CC=C(C=C5)C)=O.O=S(O)(C6=CC=C(C=C6)C)=O.O=S(O)(C7=CC=C(C=C7)C)=O

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  [Content Brief]