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Ser/Thr Kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ser/Thr Protease (1) Biochemical Assay Reagents (1) JNK (2) PKC (1) Polo-like Kinase (PLK) (2)
By Research Areas:	Cancer (5) Inflammation/Immunology (2) Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Peptides

Antibodies

Targets Recommended: Ser/Thr Kinase Ser/Thr Protease Thyroid Hormone Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126542

VRK-IN-1 5 Publications Verification	Ser/Thr Protease	Neurological Disease
VRK-IN-1 is a potent and selective inhibitor of *vaccinia-related kinases* 1 (VRK1), with an IC₅₀** of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders .

HY-102081

2OH-BNPP1 3 Publications Verification	Others	Cancer
2OH-BNPP1 is an inhibitor of BUB1 kinase, a Ser/Thr kinase, used for the treatment of cancer.

HY-11010

AS601245 Maximum Cited Publications 6 Publications Verification	JNK	Neurological Disease Inflammation/Immunology Cancer
AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC₅₀s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties .

HY-147298

Plogosertib 1 Publications Verification CYC140	Polo-like Kinase (PLK)	Cancer
Plogosertib (CYC140) is a selective, potent, and orally active ATP-competitive PLK1 inhibitor (IC₅₀: 3 nM). Plogosertib is an anti-cancer agent with anti-proliferative activity. Plogosertib can be used in the research of several tumors, including esophageal, gastric, leukemia, non–small cell lung cancer, ovarian, and squamous cell cancers .

HY-P2948

Protein serine/threonine kinase Ser/Thr protein Kinase	Biochemical Assay Reagents	Others
Protein serine/threonine kinase (Ser/Thr protein kinase) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P3766

*Protein kinase* C (alpha) peptide TFA**	PKC	Others
Protein kinase C α peptide (TFA) is a peptide of PKC-α. PKC-α acts as a lipid-dependent ser/thr protein kinase, can modulate various cellular processes, including cell survival, proliferation, differentiation, migration, adhesion and so on .

HY-11010A

AS601245 TFA	JNK	Neurological Disease Inflammation/Immunology Cancer
AS601245 TFA is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC₅₀s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 TFA exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties .

HY-123702

CAP-53194	Polo-like Kinase (PLK)	Cancer
CAP-53194 is a selective Plk1 inhibitor with potential anticancer activity. CAP-53194 was identified by a high-throughput virtual screening approach using molecular docking, showing 100-fold selectivity for Plk1 over Plk2-4 and other cell cycle kinases. CAP-53194 is able to effectively exploit subtle differences between the binding sites of Plk1 and other Ser/Thr kinases, thereby enhancing their inhibitory effects. CAP-53194 meets the Lipinski compound analog criteria and passes other ADMET filters, indicating good compound compatibility. CAP-53194 belongs to a new class of potential Plk1 inhibitors suitable for subsequent compound development and testing .

Cat. No.	Product Name

HY-L081

Phosphatase Inhibitor Library	136 compounds
Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc. Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action. MCE supplies a unique collection of 136 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

Phosphatase Inhibitor Library

136 compounds

Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.

Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.

MCE supplies a unique collection of 136 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

Cat. No.	Product Name	Target	Research Area

HY-P3766

*Protein kinase* C (alpha) peptide TFA**	PKC	Others
Protein kinase C α peptide (TFA) is a peptide of PKC-α. PKC-α acts as a lipid-dependent ser/thr protein kinase, can modulate various cellular processes, including cell survival, proliferation, differentiation, migration, adhesion and so on .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80849

	Phospho-RSK1 p90 (Thr359/Ser363) Antibody RPS6KA1; MAPKAPK1A; RSK1; Ribosomal protein S6 Kinase alpha-1; S6K-alpha-1; 90 kDa ribosomal protein S6 Kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP Kinase-activated protein Kinase 1a; MAPK-activated protein Kinase 1a; MAPKAP Kinase 1a; MAPKAP	WB, IP	Human, Mouse, Rat
	Phospho-RSK1 p90 (Thr359/Ser363) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 83 kDa, targeting to Phospho-RSK1 p90 (Thr359/Ser363). It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P82359

	MARK2 Antibody (YA2104) ELKL motif Kinase 1 antibody; ELKL motif Kinase antibody; EMK-1 antibody; EMK1 antibody; MAP/microtubule affinity regulating Kinase 2 antibody; MAP/microtubule affinity-regulating Kinase 2 antibody; Mark2 antibody; MARK2_HUMAN antibody; MGC99619 antibody; PAR 1 antibody; Par 1b antibody; PAR1 homolog antibody; Par1b antibody; Ser/Thr protein Kinase PAR 1B antibody; Serine/Threonine protein Kinase EMK antibody; Serine/Threonine protein Kinase MARK2 antibody; Serine/Threonine-protein Kinase MARK2 antibody	WB, FC	Human, Mouse, Rat
	MARK2 Antibody (YA2104) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2104), targeting MARK2, with a predicted molecular weight of 88 kDa (observed band size: 78, 82 kDa). MARK2 Antibody (YA2104) can be used for WB, FC experiment in human, mouse, rat background.

HY-P82405

	MARK3 Antibody (YA2150) C-TAK1 antibody; Cdc25C associated protein Kinase 1 antibody; Cdc25C-associated protein Kinase 1 antibody; cTAK1 antibody; ELKL motif Kinase 2 antibody; EMK-2 antibody; Emk2 antibody; ETK 1 antibody; KIAA4230 antibody; KP78 antibody; MAP microtubule affinity regulating Kinase 3 antibody; MAP/microtubule affinity-regulating Kinase 3 antibody; Mark3 antibody; MARK3_HUMAN antibody; Par 1a antibody; PAR1A antibody; Protein Kinase STK10 antibody; Ser/Thr protein Kinase PAR-1 antibody; Serine Threonine protein Kinase p78 antibody; Serine/Threonine-protein Kinase p78 antibody; SerThr protein Kinase PAR 1 antibody	WB, ICC/IF, IP, FC	Mouse, Human
	MARK3 Antibody (YA2150) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2150), targeting MARK3, with a predicted molecular weight of 84 kDa (observed band size: 84 kDa). MARK3 Antibody (YA2150) can be used for WB, ICC/IF, IP, FC experiment in mouse, human background.

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