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Streptomyces metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Endogenous Metabolite (3) ADC Cytotoxin (1) Antibiotic (7) Apoptosis (1) Bacterial (13) Biochemical Assay Reagents (1) CRM1 (1) Fungal (2) Glutathione S-transferase (1) HCV (1) HIV (1) Lipoxygenase (1) Molecular Glues (1) NO Synthase (1) Proteasome (1)
By Research Areas:	Cancer (10) Infection (18) Inflammation/Immunology (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Targets Recommended: Drug Metabolite Endogenous Metabolite

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122494A

Bialaphos sodium SF-1293 sodium	Antibiotic	Infection Inflammation/Immunology
Bialaphos (SF-1293) sodium, an antibiotic, is an effective herbicide is a metabolite of Streptomyces hygroscopicus .

HY-108549

clasto-Lactacystin β-lactone Omuralide; β-Clastolactacystin	Proteasome	Cancer
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.

HY-126708

Luisol A	ADC Cytotoxin Antibiotic	Infection
Luisol A, an aromatic tetraol, is a major metabolite of an estuarine marine actinomycete of the genus Streptomyces. Luisol A, is an anthraquinone antibiotic analog ^.

HY-W491891

1,6-Dimethoxyphenazine	Endogenous Metabolite	Others
1,6-Dimethoxyphenazine is a metabolite of Streptomyces luteoreticuli K_ATOH et A_RAI .

HY-N12900

TDD Tryptophandehydrobutyrine diketopiperazine	Others	Others
TDD (Tryptophandehydrobutyrine diketopiperazine) is a mold metabolite and can be isolated from Streptomyces spectabilis .

HY-155953

6-epi-COTC	Others	Cancer
6-epi-COTC is a diastereoisomer of Streptomyces metabolite with a anti-cancer activitie .

HY-N12145

Streptimidone Ao58A; NSC 66645	Bacterial	Infection Cancer
Streptimidone (Ao58A) is a bacterial metabolite found in Streptomyces. Streptimidone has antitumor activity .

HY-125411

Berninamycin D	Endogenous Metabolite	Others
Berninamycin D is a cyclic peptide fungal metabolite isolated from ermentation of Streptomyces bernensis .

HY-N11699

Bequinostatin A	Glutathione S-transferase	Inflammation/Immunology
Bequinostatin A is a benzo[a]naphthacenequinone metabolite that can be isolated from Streptomyces sp. MI384-DF12. Bequinostatin A shows considerable inhibitory activity against human pi class glutathione S-transferase (GST pi) .

HY-138223

6-Prenylindole	Fungal	Infection
6-Prenylindole is an antifungal agent that can be isolated from Streptomyces .

HY-131557

O-Deacetylravidomycin	Antibiotic Bacterial	Infection
O-Deacetylravidomycin, a microbial metabolite discovered in Streptomyces, is an antibiotic. O-Deacetylravidomycin exhibits light-dependent antibacterial and anticancer activities .

HY-153611

ARC12	Biochemical Assay Reagents	Others
ARC12 is a secondary metabolism probe that modulates the production of Streptomyces coelicolor secondary metabolites. ARC12 reduces the production of germicidin .

HY-137911

Sparsomycin	Bacterial	Infection Cancer
Sparsomycin is a metabolite of the bacterium Streptomyces sparsogenes. Sparsomycin inhibits protein synthesis in both eukaryotic cells and bacteria. Sparsomycin inhibits the translation extension of ribosome PTC .

HY-W747516

Butylcycloheptylprodigiosin	Antibiotic	Infection Cancer
Butylcycloheptylprodigiosin is the secondary metabolite produced by some bacteria, such as Streptomyces. Butylcycloheptylprodigiosin is a red-pigmented antibiotic and exhibits cytotoxicity against cancer cell MCF-7 and HDF .

HY-125458

Iromycin A	NO Synthase	Others
Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp. .

HY-N13018

M145724 (3Z,6E)-1-N-Methylalbonoursin	Endogenous Metabolite	Others
M145724 ((3Z,6E)-1-N-Methylalbonoursin) is a metabolite, which can be isolated from Streptomyces albus .

HY-129558

UK-1	HCV	Infection Cancer
UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities . UK-1 also inhibits HCV replication .

HY-118893

Asukamycin	Antibiotic Bacterial Fungal Molecular Glues	Infection Cancer
Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines .

HY-N6795

Leptomycin A	CRM1 HIV Antibiotic	Infection
Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B .

HY-163113

Anticancer agent 180	Others	Cancer
Anticancer agent 180 (compound 4) is a secondary metabolite present in fungal strains and extracted through physical interaction with Streptomyces sp. Anticancer agent 180 has potential anti-tumor activity and can inhibit the migration of MDA-MB-231 breast cancer cells .

HY-N12231

Carbazomycin B	Antibiotic Bacterial Lipoxygenase	Infection Cancer
Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC₅₀ Of 1.5 µM sup>[2]sup>[3]sup>[4].

HY-125066

Reveromycin B	Bacterial	Infection
Reveromycin B is a spiroketal bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells (IC₅₀=6 μg/mL) and exhibits pH-dependent antifungal activity against C. albicans (MICs=15.6 and >500 μg/mL at pH 3.0 and 7.4, respectively). Unlike reveromycin A and reveromycin C, reveromycin B does not inhibit proliferation of KB and K562 cells.

HY-W747507

Reveromycin D	Bacterial	Infection
Reveromycin D is a bacterial metabolite originally isolated from Streptomyces. It inhibits EGF-induced mitogenic activity in Balb/MK cells and has pH-dependent antifungal activity against C. albicans (MICs=2 and >500 μg/mL at pH 3 and 7.4, respectively).2 Reveromycin D also inhibits proliferation of KB and K562 cells (IC₅₀s=1.6 and 1.3 μg/mL, respectively).

HY-N8470

Steffimycin B NSC 204855; U 40615	Bacterial	Infection
Steffimycin B is an anthracycline bacterial metabolite originally isolated from Streptomyces. It binds to DNA, preferentially intercalating at sites containing cytosine and guanine.2 Steffimycin B is cytotoxic to MCF-7, KB, NCI-H187, and Vero cells (IC₅₀s=3.5, 6.75, 3.28, and 10.5 μM, respectively). It is active against M. tuberculosis (MIC=5.2 nM), B. cereus (MIC=1.56 μg/mL), and P. falciparum (IC₅₀=2.19 μM).

HY-124509

Pyrocoll	Bacterial	Infection
Pyrocoll is a bacterial metabolite originally isolated from Streptomyces. It inhibits the growth of A. aurescens, A. globiformis, A. oxydans, A. pascens, and R. erythropolis bacteria (MICs=10, 1, 10, 3, and 10 μg/mL, respectively) and HMO2, HepG2, and MCF-7 cancer cells (GI₅₀s=0.28, 0.42, and 2.2 μg/mL, respectively) in vitro. Pyrocoll is also active against P. falciparum and T. rhodesiense (IC₅₀s=1.19 and 1.97 μg/mL, respectively).

HY-127020

Deoxyenterocin	Bacterial	Infection
Deoxyenterocin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibiotic, antiviral, and antioxidant properties. It inhibits the growth of S. lutea, S. aureus, K. pneumoniae, and V. percolans in vitro when used at a concentration of 500 μg/mL. Deoxyenterocin (50 μg/mL) inhibits the cytopathic effect of influenza A H1N1 virus by 60.6% in vitro. It also prevents hydrogen peroxide-induced decreases in glutathione (GSH) levels and in the mitochondrial membrane potential in mouse primary cortical neuronal cultures when used at a concentration of 1 μM.

HY-134090

9-Methylstreptimidone Antibiotic TS 885; NSC 248958	Bacterial	Infection
9-Methylstreptimidone is a microbial metabolite originally isolated from Streptomyces sp. S-885 that has antifungal and antiviral activities. It is active against several fungi, including S. sake, S. fragilis, R. rubra, T. rubra, and C. albidus (MICs=4-20 μg/mL) and has antiviral activity against poliovirus, vesicular stomatitis virus (VSV), and Newcastle disease virus (NDV) in vitro (MIC=0.02 μg/mL for all). 9-Methylstreptimidone increases survival in mouse models of infection with influenza A2 (H2N2) or C. albicans when administered prior to infection.

HY-N8504

Neoaureothin NSC 260179; Spectinabilin	Bacterial	Infection
Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC₅₀=13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC₅₀=1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC₅₀s=34.3, 47, and 37.2 μg/mL, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50=0.84 μg/mL) and increases survival of P. densiflora trees inoculated with B. xylophilus.

HY-138185

Collismycin A SF 2738A	Bacterial Apoptosis	Cancer
Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs=6.25 and 100 μg/mL) and fungi (MICs=12.5-100 μg/mL). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC₅₀s=0.3, 0.6, and 0.3 μM, respectively) and NIH373 fibroblasts (IC₅₀=56.6 μM) but not MDA-MD-231 breast cancer cells (IC₅₀=>100 μM). Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions.3 Collismycin A (1 μM) prevents apoptosis in the brain region of zebrafish larvae in a model of neuronal cell death induced by all-trans retinoic acid.

Cat. No.	Product Name	Type

HY-131557

O-Deacetylravidomycin	Microbial Culture
O-Deacetylravidomycin, a microbial metabolite discovered in Streptomyces, is an antibiotic. O-Deacetylravidomycin exhibits light-dependent antibacterial and anticancer activities .

clasto-Lactacystin β-lactone Omuralide; β-Clastolactacystin	Classification of Application Fields Disease Research Fields Cancer	Proteasome
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.

Luisol A	Infection Structural Classification Natural Products Monophenols Microorganisms Classification of Application Fields Source classification Marine natural products Phenols Disease Research Fields Marine microorganism	ADC Cytotoxin Antibiotic
Luisol A, an aromatic tetraol, is a major metabolite of an estuarine marine actinomycete of the genus Streptomyces. Luisol A, is an anthraquinone antibiotic analog ^.

1,6-Dimethoxyphenazine	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
1,6-Dimethoxyphenazine is a metabolite of Streptomyces luteoreticuli K_ATOH et A_RAI .

TDD Tryptophandehydrobutyrine diketopiperazine	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Others
TDD (Tryptophandehydrobutyrine diketopiperazine) is a mold metabolite and can be isolated from Streptomyces spectabilis .

Streptimidone Ao58A; NSC 66645	Structural Classification Alkaloids Piperidine Alkaloids Microorganisms Source classification	Bacterial
Streptimidone (Ao58A) is a bacterial metabolite found in Streptomyces. Streptimidone has antitumor activity .

Berninamycin D	Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Other Diseases Pyridine Alkaloids Disease Research Fields	Endogenous Metabolite
Berninamycin D is a cyclic peptide fungal metabolite isolated from ermentation of Streptomyces bernensis .

Bequinostatin A	Quinones Structural Classification Microorganisms Anthraquinones Source classification	Glutathione S-transferase
Bequinostatin A is a benzo[a]naphthacenequinone metabolite that can be isolated from Streptomyces sp. MI384-DF12. Bequinostatin A shows considerable inhibitory activity against human pi class glutathione S-transferase (GST pi) .

Butylcycloheptylprodigiosin	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source classification	Antibiotic
Butylcycloheptylprodigiosin is the secondary metabolite produced by some bacteria, such as Streptomyces. Butylcycloheptylprodigiosin is a red-pigmented antibiotic and exhibits cytotoxicity against cancer cell MCF-7 and HDF .

Iromycin A	Structural Classification Natural Products Microorganisms Source classification	NO Synthase
Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp. .

M145724 (3Z,6E)-1-N-Methylalbonoursin	Structural Classification Natural Products Microorganisms Source classification	Endogenous Metabolite
M145724 ((3Z,6E)-1-N-Methylalbonoursin) is a metabolite, which can be isolated from Streptomyces albus .

Asukamycin	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial Fungal Molecular Glues
Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines .

Leptomycin A	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	CRM1 HIV Antibiotic
Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B .

Anticancer agent 180	Structural Classification Microorganisms Source classification Phenols	Others
Anticancer agent 180 (compound 4) is a secondary metabolite present in fungal strains and extracted through physical interaction with Streptomyces sp. Anticancer agent 180 has potential anti-tumor activity and can inhibit the migration of MDA-MB-231 breast cancer cells .

Carbazomycin B	Structural Classification Monophenols Microorganisms Source classification Phenols	Antibiotic Bacterial Lipoxygenase
Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC₅₀ Of 1.5 µM sup>[2]sup>[3]sup>[4].

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Streptomyces metabolite

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