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Results for "

anxiolyticlike

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (9) Adenylate Cyclase (1) Calcium Channel (2) Cholecystokinin Receptor (1) ERK (1) Formyl Peptide Receptor (FPR) (2) GABA Receptor (4) iGluR (1) Melatonin Receptor (1) mGluR (7) nAChR (1) Neurokinin Receptor (1) NO Synthase (1) Opioid Receptor (2) Phosphodiesterase (PDE) (1) Trk Receptor (2)
By Research Areas:	Cancer (1) Endocrinology (1) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (34)

Inhibitors & Agonists

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100936

Etazolate hydrochloride SQ 20009; EHT 0202 hydrochloride	Phosphodiesterase (PDE) GABA Receptor	Neurological Disease Inflammation/Immunology
Etazolate hydrochloride (SQ 20009) is an orally active, selective inhibitor of type 4 phosphodiesterase (PDE4) with an IC₅₀ of 2 μM. Etazolate hydrochloride is a γ-aminobutyric acid A (GABA_A) receptor regulator. Etazolate hydrochloride is an α-secretase activator and induced the production of soluble amyloid precursor protein (sAPPα). Etazolate hydrochloride, a pyrazolopyridine class derivative, increases cAMP levels. Etazolate hydrochloride has anxiolyticlike, antidepressant-like and anti-inflammatory effects .

HY-141795

Posovolone Co 134444	Others	Neurological Disease
Posovolone (Co 134444) is an orally active, neuroactive steroid. Posovolone has anticonvulsant and anxiolytic-like activity as well as ataxic effects .

HY-101387

rel-ACPT-I	mGluR	Neurological Disease
rel-ACPT-I is an agonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects .

HY-107722

SCH 221510	Opioid Receptor	Neurological Disease
SCH 221510 is a potent, orally active and selective NOP (nociceptin opioid receptor) agonist, with an EC₅₀ of 12 nM and K_i of 0.3 nM. SCH 221510 shows an anxiolytic-like effect .

HY-107702

CGP 37849	iGluR	Neurological Disease
CGP 37849 is a potent, competitive and orally active N-methyl-D-aspartate (NMDA) receptor antagonist. CGP 37849 is an anticonvulsant in rodents and has antidepressant and anxiolytic-like effects .

HY-101322A

MM 77 dihydrochloride	5-HT Receptor	Neurological Disease
MM 77 dihydrochloride is a potent postsynaptic antagonist of the 5-HT_1A receptor. MM 77 dihydrochloride exhibits anxiolytic-like activity .

HY-103571

VU0285683	mGluR	Neurological Disease
VU0285683 is a selective mGluR5 positive allosteric modulator (PAM). VU0285683 has anxiolytic-like activity in rodent models for anxiety .

HY-101387A

ACPT-II	mGluR	Neurological Disease
ACPT-II is an antagonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects .

HY-118008A

Lesopitron hydrochloride	5-HT Receptor	Neurological Disease
Lesopitron hydrochloride is a 5-HT receptor agonist with potent anxiolytic-like effects. Lesopitron hydrochloride inhibits forskolin-stimulated adenylate cyclase activity with an IC₅₀ value of 125 nM .

HY-103357

LY288513	Cholecystokinin Receptor	Neurological Disease
LY288513 is a selective non-peptide CCK-B receptor antagonist with an IC₅₀ value of 16 nM. LY288513 produces an anxiolytic-like action in mice .

HY-118008

Lesopitron	5-HT Receptor	Neurological Disease
Lesopitron (E-4424) is a 5-HT receptor agonist with potent anxiolytic-like effects. Lesopitron inhibits forskolin-stimulated adenylate cyclase activity with an IC₅₀ value of 125 nM .

HY-110278

ADX71743	mGluR	Neurological Disease
ADX71743 is a highly selective, noncompetitive and brain-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM). ADX71743 has anxiolytic-like activity .

HY-13206

MTEP hydrochloride 3 Publications Verification	mGluR	Neurological Disease
MTEP hydrochloride is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC₅₀ of 5 nM and a K_i of 16 nM. MTEP hydrochloride shows antidepressant and anxiolytic-like effects. MTEP hydrochloride can be used for Parkinson's disease research .

HY-101316

TRIM	NO Synthase	Neurological Disease
TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC₅₀ values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects .

HY-120738

p-MPPI hydrochloride 1 Publications Verification	5-HT Receptor	Neurological Disease
p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects .

HY-110146

XAP044	mGluR	Neurological Disease
XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms .

HY-P1178

Cyclotraxin B 3 Publications Verification	Trk Receptor	Neurological Disease
Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC₅₀ of 0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

HY-103133

WAY208466 dihydrochloride	5-HT Receptor	Neurological Disease
WAY 208466 dihydrochloride is a potent and selective 5-HT₆ receptor agonist (EC₅₀=7.3 nM for the human 5-HT₆ receptor). WAY-208466 dihydrochloride elevates cortical GABA levels in rat frontal cortex . WAY 208466 dihydrochloride exhibits antidepressant and anxiolytic-like effects .

HY-P1178A

Cyclotraxin B TFA	Trk Receptor	Neurological Disease
Cyclotraxin B TFA, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B TFA non-competitively inhibits BDNF-induced TrkB activity with an IC₅₀ of 0.30 nM. Cyclotraxin B TFA can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

HY-101369

BW-723C86	5-HT Receptor	Neurological Disease
BW-723C86 is a potent and a selective 5-HT2B receptor agonist. BW-723C86 exhibits anxiolytic-like actions. BW-723C86 also causes hyperphagia and reduced grooming in rats .

HY-13206A

MTEP	mGluR	Neurological Disease
MTEP is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC₅₀ of 5 nM and a K_i of 16 nM. MTEP shows antidepressant and anxiolytic-like effects. MTEP can be used for Parkinson's disease research . MTEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-19505

TPA-023B	GABA Receptor	Neurological Disease
TPA-023B is a high-affinity and orally active GABA_A receptor α2/α3 subtype (K_is of 0.73 nM/2 nM) partial agonist and a α1 subtype (K_i of 1.8 nM) antagonist. TPA-023B has non-sedating anxiolytic-like properties .

HY-103135

SB 206553 hydrochloride	5-HT Receptor	Neurological Disease
SB 206553 hydrochloride is a high affinity, selective and orally active 5-HT_2B / 5-HT_2C receptor antagonist (rat 5-HT_2B pA2 = 8.89, human 5-HT_2C pKi = 7.92) . SB 206553 possesses anxiolytic-like properties .

HY-130176

UFP-512	Opioid Receptor ERK Adenylate Cyclase	Neurological Disease
UFP-512 is a selective and potent σ-opioid receptor (DOP receptor) peptidic agonist with antidepressant- and anxiolytic-like effects. UFP-512 exhibits as a potent agonist on adenylyl cyclase inhibition and Erk1/2 activation. UFP-512 induces phosphorylation of DOP receptors on Ser ³⁶³ with a low desensitization of the cAMP pathway. UFP-512 is promising for research of mood disorders .

HY-117955

GMA-839 WAY 141839; Co 2-6749	GABA Receptor	Neurological Disease
GMA-839 is a selective modulator of the γ-aminobutyric acid A receptor (GABA_A) with an IC₅₀ value of 230 nM. GMA-839 exhibits potent anxiolytic-like activity, demonstrating significant dose-dependent anxiolytic effects in animal models, with an effective oral dose of 1.6 mg/kg. Significant increases in punished responding were observed in squirrel monkeys and pigeons. GMA-839 shows promise for research in the field of anxiolytics .

HY-101358

8-M-PDOT AH-002	Melatonin Receptor	Neurological Disease
8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity .

HY-19490

VQW-765 AQW-051	nAChR	Neurological Disease
VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pK_D value of 7.56 to recombinantly expressed human α7-nAChR. VQW-765 shows anxiolytic-like effect in vivo. VQW-765 can be used for the research of anxiety disorder and acute performance anxiety .

HY-107691

GR 159897	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide neurokinin 2 (NK₂) receptor antagonist. GR 159897 has little or no affinity for NK₁ and NK₃ receptors. GR 159897 inhibits binding of [ ³H]GR100679 to human NK₂ (hNK₂)-CHO cells and rat colon membranes with pK_is of 9.51 and 10, respectively. Antagonizes bronchoconstriction. Anxiolytic-like and anti-tumor effects .

HY-P1117

MMK1	Formyl Peptide Receptor (FPR) Calcium Channel	Neurological Disease Inflammation/Immunology
MMK1 is a potent and selective *human formyl peptide receptor like-1 (FPRL-1/FPR2)* agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity .

HY-P1117A

MMK1 TFA	Formyl Peptide Receptor (FPR) Calcium Channel	Neurological Disease Inflammation/Immunology
MMK1 TFA is a potent and selective *human formyl peptide receptor like-1 (FPRL-1/FPR2)* agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity .

HY-160887

FPT	5-HT Receptor	Neurological Disease
FPT, a 2-Aminotetralin, is an efficacious partial agonist at 5-HT_1AR, a full agonist at 5-HT_1BR and 5-HT_1DR with EC₅₀s of 39.3 nM, 1.2 nM, 0.5 nM, respectively. FPT is a weak agonist at 5-HT₇R. FPT shows in vivo efficacy as an antiepileptic in Fmr1 knockout mice and has anxiolytic-like and prosocial effects in Fmr1 knockout mice and other mouse models .

HY-163150

5-HT6R antagonist 3	5-HT Receptor	Neurological Disease
5-HT6R antagonist 3 (compound 15) is a potent, selective and brain-penetrant 5-HT6R antagonist with K_i values of 14 nM, 3533 nM, 35 nM, 1449 nM for 5-HT6, 5-HT1A, 5-HT2A, 5-HT7, respectively. 5-HT6R antagonist 3 shows anxiolytic-like and properties neuroprotective and procognitive-like effects. 5-HT6R antagonist 3 has the potential for the research of Alzheimer’s Disease .

HY-W677042

α-Androstenol 5α-Androst-16-en-3α-ol	GABA Receptor	Neurological Disease
α-Androstenol (5α-Androst-16-en-3α-ol) is a steroid pheromone that has been found in boar testes and human male axillary sweat. α-Androstenol is also a positive modulator of GABAA receptors, which enhances GABA-activated currents in primary mouse cerebellar granule cells (EC₅₀=0.4 uM). α-Androstenol decreases immobility time in the forced swim test and increases time spent in the open arms of the elevated plus maze in mice. α-Androstenol protects against seizures induced by Pentylenetetrazole or electroshock with anxiolytic-like activity in mice .

Cat. No.	Product Name	Target	Research Area

HY-P1178

Cyclotraxin B 3 Publications Verification	Trk Receptor	Neurological Disease
Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC₅₀ of 0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

HY-P1117

MMK1	Formyl Peptide Receptor (FPR) Calcium Channel	Neurological Disease Inflammation/Immunology
MMK1 is a potent and selective *human formyl peptide receptor like-1 (FPRL-1/FPR2)* agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity .

HY-P10397

YHIEPV rALP-2, Rubisco anxiolytic-like peptide 2	Peptides	Neurological Disease Metabolic Disease
YHIEPV (rALP-2, Rubisco anxiolytic-like peptide 2) is a potent and orally active peptide. YHIEPV shows anxiolytic effects. YHIEPV increases leptin sensitivity to exert its anti-obesity effects .

HY-P1178A

Cyclotraxin B TFA	Trk Receptor	Neurological Disease
Cyclotraxin B TFA, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B TFA non-competitively inhibits BDNF-induced TrkB activity with an IC₅₀ of 0.30 nM. Cyclotraxin B TFA can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects .

HY-P1117A

MMK1 TFA	Formyl Peptide Receptor (FPR) Calcium Channel	Neurological Disease Inflammation/Immunology
MMK1 TFA is a potent and selective *human formyl peptide receptor like-1 (FPRL-1/FPR2)* agonist with EC₅₀s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity .

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