2. Immunology/Inflammation
  3. NO Synthase
  4. TRIM

TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects.

For research use only. We do not sell to patients.

TRIM Chemical Structure

TRIM Chemical Structure

CAS No. : 25371-96-4

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Based on 1 publication(s) in Google Scholar

TRIM Related Antibodies

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nNOS iNOS eNOS

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Description

TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects[1][2].

IC50 & Target

iNOS

 

nNOS

 

In Vitro

TRIM is a relatively weak inhibitor of eNOS (IC50, 1057.5 µM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TRIM Related Antibodies
Clinical Trial
Molecular Weight

212.17

Formula

C10H7F3N2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC(C1=CC=CC=C1N2C=CN=C2)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1178.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7132 mL 23.5660 mL 47.1320 mL
5 mM 0.9426 mL 4.7132 mL 9.4264 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7132 mL 23.5660 mL 47.1320 mL 117.8300 mL
5 mM 0.9426 mL 4.7132 mL 9.4264 mL 23.5660 mL
10 mM 0.4713 mL 2.3566 mL 4.7132 mL 11.7830 mL
15 mM 0.3142 mL 1.5711 mL 3.1421 mL 7.8553 mL
20 mM 0.2357 mL 1.1783 mL 2.3566 mL 5.8915 mL
25 mM 0.1885 mL 0.9426 mL 1.8853 mL 4.7132 mL
30 mM 0.1571 mL 0.7855 mL 1.5711 mL 3.9277 mL
40 mM 0.1178 mL 0.5892 mL 1.1783 mL 2.9458 mL
50 mM 0.0943 mL 0.4713 mL 0.9426 mL 2.3566 mL
60 mM 0.0786 mL 0.3928 mL 0.7855 mL 1.9638 mL
80 mM 0.0589 mL 0.2946 mL 0.5892 mL 1.4729 mL
100 mM 0.0471 mL 0.2357 mL 0.4713 mL 1.1783 mL
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TRIM Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRIM25371-96-4NO SynthaseNitric oxide synthasesNOSantidepressantanxiolytic-like effectsnNOSiNOSeNOSInhibitorinhibitorinhibit

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