2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. VQW-765

VQW-765  (Synonyms: AQW-051)

Cat. No.: HY-19490 Purity: 99.34% ee.: 99.64%
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VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pKD value of 7.56 to recombinantly expressed human α7-nAChR. VQW-765 shows anxiolytic-like effect in vivo. VQW-765 can be used for the research of anxiety disorder and acute performance anxiety.

For research use only. We do not sell to patients.

VQW-765 Chemical Structure

VQW-765 Chemical Structure

CAS No. : 669770-29-0

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Based on 1 publication(s) in Google Scholar

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VQW-765 Related Antibodies

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Description

VQW-765 (AQW-051) is a selective and orally active alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonist with a pKD value of 7.56 to recombinantly expressed human α7-nAChR. VQW-765 shows anxiolytic-like effect in vivo. VQW-765 can be used for the research of anxiety disorder and acute performance anxiety[1].

In Vitro

VQW-765 shows a binding efficacy with a pKD value of 7.56 to recombinantly expressed human α7-nACh receptor[1].
VQW-765 shows a potent agonist activity to calcium transients that detected after stimulation of human α7-nACh receptors recombinantly expressed in GH3-ha7-22 cells with a pEC50 value of 7.41[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VQW-765 Related Antibodies
In Vivo

VQW-765 (0.03 and 0.3 mg/kg; oral administration once) increases cognitive effect and learning/memory performance in mice[1].
VQW-765 (1 mg/kg; oral administration once) shows anxiolytic-like effect with increasing the social exploration time in rats with a duration of at least 6 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: OF1/IC strain adult mice[1]
Dosage: 0.03 and 0.3 mg/kg
Administration: Oral administration; 0.03 and 0.3 mg/kg once
Result: Increased the learning/memory performance with more time to scrutinize the novel partner than the familiar partner during the re-test trial at 24 h. Showed cognitive-enhancing effects in mice by the object recognition test (ORT).
Clinical Trial
Molecular Weight

294.39

Formula

C19H22N2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=C(C2=CC=C(O[C@H]3CN4CCC3CC4)C=N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (56.63 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3969 mL 16.9843 mL 33.9685 mL
5 mM 0.6794 mL 3.3969 mL 6.7937 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3969 mL 16.9843 mL 33.9685 mL 84.9214 mL
5 mM 0.6794 mL 3.3969 mL 6.7937 mL 16.9843 mL
10 mM 0.3397 mL 1.6984 mL 3.3969 mL 8.4921 mL
15 mM 0.2265 mL 1.1323 mL 2.2646 mL 5.6614 mL
20 mM 0.1698 mL 0.8492 mL 1.6984 mL 4.2461 mL
25 mM 0.1359 mL 0.6794 mL 1.3587 mL 3.3969 mL
30 mM 0.1132 mL 0.5661 mL 1.1323 mL 2.8307 mL
40 mM 0.0849 mL 0.4246 mL 0.8492 mL 2.1230 mL
50 mM 0.0679 mL 0.3397 mL 0.6794 mL 1.6984 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VQW-765669770-29-0AQW-051VQW765VQW 765AQW051AQW 051nAChRNicotinic acetylcholine receptorsoralanxiolytic-likeanxiety disorderacute performance anxietyGH3-ha7-22cognitive effectlearning performancemiceInhibitorinhibitorinhibit

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