SB 206553 hydrochloride

Cat. No.: HY-103135 Purity: 98.8%: FAQs
Data Sheet SDS COA Handling Instructions

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SB 206553 hydrochloride is a high affinity, selective and orally active 5-HT_2B / 5-HT_2C receptor antagonist (rat 5-HT_2B pA2 = 8.89, human 5-HT_2C pKi = 7.92). SB 206553 possesses anxiolytic-like properties.

For research use only. We do not sell to patients.

SB 206553 hydrochloride Chemical Structure

CAS No. : 1197334-04-5

Size	Price	Stock	Quantity
5 mg	USD 257	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Other Forms of SB 206553 hydrochloride:

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5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

Biological Activity
Purity & Documentation
References
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Description

SB 206553 hydrochloride is a high affinity, selective and orally active 5-HT_2B / 5-HT_2C receptor antagonist (rat 5-HT_2B pA2 = 8.89, human 5-HT_2C pKi = 7.92)^[1]. SB 206553 possesses anxiolytic-like properties^[2].

Molecular Weight

328.80

Formula

C₁₇H₁₇ClN₄O

CAS No.

1197334-04-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1C(C(CC1)=C2)=CC3=C2N(C)C=C3)NC4=CC=CN=C4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 32.88 mg/mL (100.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0414 mL	15.2068 mL	30.4136 mL
5 mM	0.6083 mL	3.0414 mL	6.0827 mL
10 mM	0.3041 mL	1.5207 mL	3.0414 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.8%

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Data Sheet (276 KB) SDS (251 KB)

COA (256 KB)

Handling Instructions (2659 KB)

References

[1]. Forbes IT, et al. 5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity, and oral activity. J Med Chem. 1995 Jul 7;38(14):2524-30. [Content Brief]

[2]. Kennett GA, et al. In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties. Br J Pharmacol. 1996 Feb;117(3):427-434. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0414 mL	15.2068 mL	30.4136 mL	76.0341 mL
	5 mM	0.6083 mL	3.0414 mL	6.0827 mL	15.2068 mL
	10 mM	0.3041 mL	1.5207 mL	3.0414 mL	7.6034 mL
	15 mM	0.2028 mL	1.0138 mL	2.0276 mL	5.0689 mL
	20 mM	0.1521 mL	0.7603 mL	1.5207 mL	3.8017 mL
	25 mM	0.1217 mL	0.6083 mL	1.2165 mL	3.0414 mL
	30 mM	0.1014 mL	0.5069 mL	1.0138 mL	2.5345 mL
	40 mM	0.0760 mL	0.3802 mL	0.7603 mL	1.9009 mL
	50 mM	0.0608 mL	0.3041 mL	0.6083 mL	1.5207 mL
	60 mM	0.0507 mL	0.2534 mL	0.5069 mL	1.2672 mL
	80 mM	0.0380 mL	0.1901 mL	0.3802 mL	0.9504 mL