2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. UFP-512

UFP-512 is a selective and potent σ-opioid receptor (DOP receptor) peptidic agonist with antidepressant- and anxiolytic-like effects. UFP-512 exhibits as a potent agonist on adenylyl cyclase inhibition and Erk1/2 activation. UFP-512 induces phosphorylation of DOP receptors on Ser363 with a low desensitization of the cAMP pathway. UFP-512 is promising for research of mood disorders.

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UFP-512 Chemical Structure

UFP-512 Chemical Structure

CAS No. : 480446-44-4

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UFP-512 Related Antibodies

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

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Description

UFP-512 is a selective and potent σ-opioid receptor (DOP receptor) peptidic agonist with antidepressant- and anxiolytic-like effects. UFP-512 exhibits as a potent agonist on adenylyl cyclase inhibition and Erk1/2 activation. UFP-512 induces phosphorylation of DOP receptors on Ser363 with a low desensitization of the cAMP pathway. UFP-512 is promising for research of mood disorders[1].

Molecular Weight

555.62

Formula

C31H33N5O5
CAS No.
SMILES

CC(C=C(C=C1C)O)=C1C[C@H](N)C(N2[C@@H](CC3=CC=CC=C3C2)C(N[C@H](C4=NC5=CC=CC=C5N4)CC(O)=O)=O)=O
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Purity & Documentation
References
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UFP-512 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UFP-512480446-44-4UFP512UFP 512Opioid ReceptorDOP receptorantidepressantanxiolyticadenylyl cyclaseErk1/2mood disordersInhibitorinhibitorinhibit

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