Cyclotraxin B

Name: Cyclotraxin B
Brand: MedChemExpress
SKU: HY-P1178
Rating: 5.0 (3 reviews)

Cat. No.: HY-P1178 Purity: 98.11%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC₅₀ of 0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclotraxin B Chemical Structure

CAS No. : 1203586-72-4

Size	Price	Stock	Quantity
1 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 360	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 590	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Cyclotraxin B:

Cyclotraxin B TFA Get quote

3 Publications Citing Use of MCE Cyclotraxin B

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View All Isoforms

TrkA TrkB TrkC Trk

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

TrkB

Molecular Weight

1200.37

Formula

C₄₈H₇₃N₁₃O₁₇S₃

CAS No.

1203586-72-4

Appearance

Solid

Color

White to off-white

Sequence Shortening

CNPMGYTKEGC (Disulfide bridge:Cys1-Cys11)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Stored under nitrogen, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (83.31 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8331 mL	4.1654 mL	8.3308 mL
5 mM	0.1666 mL	0.8331 mL	1.6662 mL
10 mM	0.0833 mL	0.4165 mL	0.8331 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (83.31 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.11%

Select Batch:

Data Sheet (285 KB) SDS (252 KB)

COA (267 KB) RP-HPLC (113 KB) MS (206 KB)

Handling Instructions (2659 KB)

References

[1]. Maxime Cazorla, et al. Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice. PLoS One. 2010 Mar 19;5(3):e9777. [Content Brief]

[2]. Luis Constandil, et al. Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J Pain. 2012 Jun;13(6):579-89. [Content Brief]

[3]. Michel M M Verheij, et al. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex. J Neurosci. 2016 Aug 3;36(31):8149-59. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.8331 mL	4.1654 mL	8.3308 mL	20.8269 mL
	5 mM	0.1666 mL	0.8331 mL	1.6662 mL	4.1654 mL
	10 mM	0.0833 mL	0.4165 mL	0.8331 mL	2.0827 mL
	15 mM	0.0555 mL	0.2777 mL	0.5554 mL	1.3885 mL
	20 mM	0.0417 mL	0.2083 mL	0.4165 mL	1.0413 mL
	25 mM	0.0333 mL	0.1666 mL	0.3332 mL	0.8331 mL
	30 mM	0.0278 mL	0.1388 mL	0.2777 mL	0.6942 mL
	40 mM	0.0208 mL	0.1041 mL	0.2083 mL	0.5207 mL
	50 mM	0.0167 mL	0.0833 mL	0.1666 mL	0.4165 mL
	60 mM	0.0139 mL	0.0694 mL	0.1388 mL	0.3471 mL
	80 mM	0.0104 mL	0.0521 mL	0.1041 mL	0.2603 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Cyclotraxin B Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclotraxin B1203586-72-4Trk ReceptorTropomyosin related kinase receptorTrkBanxiolytic-likeBDNFcyclicpeptideBBBanalgesicInhibitorinhibitorinhibit

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Cyclotraxin B

Customer Review

Other Forms of Cyclotraxin B:

Cyclotraxin B Related Antibodies

3 Publications Citing Use of MCE Cyclotraxin B

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Trk Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Cyclotraxin B Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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