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Results for "

cGMP-dependent

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (1) Bacterial (1) Fluorescent Dye (1) Myosin (3) Parasite (3) Phosphodiesterase (PDE) (1) PKA (4) PKC (4) PKG (8) Potassium Channel (1) Ras (1) ROCK (3) Ser/Thr Protease (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (4) Infection (4) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (4)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Click Chemistry

Targets Recommended: Apical Sodium-Dependent Bile Acid Transporter CaMK CDK SNIPERs DNA-PK VDAC SGLT PDK-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P1561

PKG Substrate	PKG	Neurological Disease
PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).

HY-P1292

PKG inhibitor peptide	PKG	Cancer
PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a K_i of 86 μM .

HY-P1292A

PKG inhibitor peptide TFA	PKG	Cancer
PKG inhibitor peptide TFA is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a K_i of 86 μM .

HY-137373

Rp-8-pCPT-cGMPS	PKG	Others
Rp-8-pCPT-cGMPS is a competitive inhibitor of cGMP-dependent protein kinase (PKG) (K_i=0.5 μM). Rp-8-pCPT-cGMPS has high lipid solubility and can more easily penetrate the cell membrane and reach sufficient concentration inside the cell to inhibit cGMP-dependent protein kinase. Rp-8-pCPT-cGMPS can be used to study the activity and function of cGMP-dependent protein kinase in platelets .

HY-145233

PfPKG-IN-1	Parasite	Infection
PfPKG-IN-1 is a imidazole-based inhibitor of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG).

HY-137622

Sp-cGMPS	PKG	Cardiovascular Disease
Sp-cGMPS is an activator of cGMP-dependent protein kinases (PKGs). Sp-cGMPS can be used in cardiovascular disease-related research .

HY-153538

AP-C2	Ser/Thr Protease	Metabolic Disease
AP-C2 is a potent *guanosine 3',5'-cyclic monophosphate (cGMP)-dependent* protein kinase II (cGKII) inhibitor with a pIC₅₀** of 5.2 .

HY-161309

PfPKG-IN-2	Parasite	Infection
PfPKG-IN-2 (compound 53) is a potent Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) inhibitor with an IC₅₀ value of 13 nM. PfPKG-IN-2 shows antiparasitic activity .

HY-134299

8-CPT-cAMP-AM 8-(4-Chlorophenylthio)-cAMP-AM	Ras Others	Others
8-CPT-cAMP-AM is a highly membrane-permeant analogue of signal molecule cAMP. 8-CPT-cAMP-AM is an activator of *cAMP- and cGMP-dependent* protein kinases and of Epac** (exchange protein activated by cAMP) .

HY-153540

AP-C4	Others	Others
AP-C4 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 5.2. AP-C3 does not inhibit cGKII-dependent anion secretion .

HY-153541

AP-C7	Others	Others
AP-C7 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 5.0. AP-C7 only weakly inhibits cGKII-dependent anion secretion .

HY-153537

AP-C1	Others	Others
AP-C1 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 6.5. AP-C1 only weakly inhibits cGKII-dependent anion secretion .

HY-153539

AP-C3	Others	Others
AP-C3 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 6.3. AP-C3 only weakly inhibits cGKII-dependent anion secretion .

HY-102050

PF-05085727	Phosphodiesterase (PDE)	Neurological Disease
PF-05085727 is a potent, selective and brain penetrant inhibitor of cGMP-dependent PDE2A (IC₅₀=2 nM). PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11 .

HY-134271

*8-Br-cGMP-AM*	PKG	Cardiovascular Disease
8-Br-cGMP-AM is a derivative of 8-Br-cGMP. As an activator of PKG (cGMP-dependent protein kinase), it can lead to a variety of biological effects such as vasodilation and platelet inhibition. 8-Br-cGMP-AM can be used in the study of cardiovascular diseases .

HY-134311

8-NBD-cGMP	Fluorescent Dye	Others
8-NBD-cGMP is a fluorescent analog of cyclic guanosine monophosphate and a potent, membrane-permeable, fluorescent activator of cGMP-dependent protein kinase isozymes I α and I β. 8-NBD-cGMP is barely fluorescent in aqueous solution but fluoresces strongly in hydrophobic environments such as hydrophobic protein binding sites

HY-153542

AP-C6	Others	Others
AP-C6 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 6.5. AP-C6 concentration-dependently inhibits human cGKII activity in vitro. AP-C6 potentiate cAMP signaling by PDE inhibition .

HY-110221

Rp-8-pCPT-cGMPS sodium	PKG	Neurological Disease
Rp-8-pCPT-cGMPS sodium is the sodium salt form of Rp-8-pCPT-cGMPS. Rp-8-pCPT-cGMPS is an inhibitor for cGMP-dependent protein kinase (cGK). Rp-8-pCPT-cGMPS sodium is an agonist for cyclic nucleotide-gated (CNG) channels in a voltage-dependent manner .

HY-12880

HA-100 dihydrochloride	Myosin PKA PKC ROCK	Cancer
HA-100 dihydrochloride is a potent protein kinase inhibitor, with IC₅₀s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 dihydrochloride also used as a ROCK inhibitor .

HY-100984

HA-100 1 Publications Verification	PKA PKC Myosin ROCK	Cancer
HA-100 is a potent protein kinase inhibitor, with IC₅₀s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), *cAMP-dependent* protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 also used as a ROCK** inhibitor .

HY-100984A

HA-100 hydrochloride	PKA PKC Myosin ROCK	Cancer
HA-100 hydrochloride is a potent protein kinase inhibitor, with IC₅₀s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 hydrochloride also used as a ROCK inhibitor .

HY-130354

*Dibutyryl-cGMP* sodium** 2 Publications Verification Bt2cGMP sodium	Potassium Channel	Cardiovascular Disease
Dibutyryl-cGMP sodium (Bt2cGMP sodium) is a cell-permeable cGMP analogue. Dibutyryl-cGMP sodium preferentially activates cGMP-dependent protein kinase (PKG). Dibutyryl-cGMP sodium inhibits the release of [ ³H]-arachidonic acid from γ thrombin-stimulated human platelets. Dibutyryl-cGMP sodium induces peripheral antinociception via activation of ATP-sensitive K ⁺ channels .

HY-137378A

8-Br-PET-cGMP	Others	Cardiovascular Disease Inflammation/Immunology
8-Br-PET-cGMP is an agonist of cGMP-dependent protein kinase type I (cGKI). 8-Br-PET-cGMP promotes the dimerization of cGKI and activates its catalytic activity by binding to the regulatory domain of cGKI. 8-Br-PET-cGMP can be used to study the role of cGMP signaling pathways in cell growth, vasodilation, and smooth muscle cell function .

HY-101525

MBP146-78 2 Publications Verification	Parasite	Infection
MBP146-78 is a potent and selective inhibitor of *cGMP* dependent protein kinases.

HY-N6791

KT5823 Maximum Cited Publications 6 Publications Verification	PKA PKC Bacterial Apoptosis Antibiotic	Infection Inflammation/Immunology
KT5823, a selective the cGMP-dependent protein kinase (PKG) inhibitor with an K_i value of 0.23 μM, it also inhibits PKA and PKC with K_i values of 10 μM and 4 μM, respectively. KT5823 is a Staurosporine-related protein kinase inhibitor, increases thyroid-stimulating hormone-induced (Na ⁺/I ^- symporter) NIS expression, and iodide uptake in thyroid cells. KT5823 arrests cells after the G0/G1 boundary and causes increases in the levels of apoptotic DNA fragmentation .

HY-137633

Sp-8-Br-PET-cGMPS	PKG	Neurological Disease
Sp-8-Br-PET-cGMPS is a membrane-permeable PKG agonist and a membrane-permeable inhibitor of retinal-type cGMP-gated ion channels, as well as an activator of cGMP-dependent protein kinases I α and I β. Sp-8-Br-PET-cGMPS is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, has no metabolic side effects, and is more lipophilic and permeable than Sp-8-pCPT-cGMPS. Sp-8-Br-PET-cGMPS can be used to study the role of cGMP signaling pathways in the nervous system .

HY-108548

Rp-8-Br-PET-cGMPS sodium Rp-8-Bromo-PET-cGMPS	Others	Inflammation/Immunology
Rp-8-bromo-PET-Cyclic GMPS (Rp-8-bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis=35 and 30 nM). It less potently inhibits protein kinase A (Ki=11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC₅₀=25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki=1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.

Cat. No.	Product Name	Target	Research Area

HY-P1561

PKG Substrate	PKG	Neurological Disease
PKG Substrate is a selective substrate for cGMP-dependent protein kinase (PKG).

HY-P1292

PKG inhibitor peptide	PKG	Cancer
PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a K_i of 86 μM .

HY-P1292A

PKG inhibitor peptide TFA	PKG	Cancer
PKG inhibitor peptide TFA is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a K_i of 86 μM .

HY-P2692A

DT-2	Peptides	Cancer
DT-2 is a potent and selective inhibitor of the cGMP-dependent protein kinase (PKG). DT-2 inhibits PKG catalyzed phosphorylation (K_{i_{: 12.5 nM) .}}

Species:	Human (4)
Tag:	His (2) GST (2)
Source:	HEK293 (1) Sf9 insect cells (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P701759

	PRKG2 Protein, Human (Sf9, GST) PRKG2; cGMP-dependent protein kinase 2; cGK 2; cGK2; cGMP-dependent protein kinase II; cGKII	Human	Sf9 insect cells
	PRKG2 protein is a key regulator that activates CFTR to promote intestinal secretion and affect bone growth. It phosphorylates CFTR, coordinating cGMP-dependent translocation in the jejunum. PRKG2 Protein, Human (Sf9, GST) is the recombinant human-derived PRKG2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of PRKG2 Protein, Human (Sf9, GST) is 762 a.a., .

HY-P71234

	PRKG1 Protein, Human (HEK293, His) cGMP-dependent Protein Kinase 1; cGK 1; cGK1; cGMP-dependent Protein Kinase I; cGKI; PRKG1; PRKG1B; PRKGR1A; PRKGR1B	Human	HEK293
	PRKG1, a serine/threonine protein kinase, mediates the NO/csignaling pathway, phosphorylating various cellular proteins. It influences platelet activation, smooth muscle contraction, cardiac function, CNS processes, and more. PRKG1 regulates intracellular calcium levels, inhibits IP3-induced Ca(2+) release, and phosphorylates channels like KCNMA1 and TRPC. It inactivates RhoA, affecting processes like vesicle trafficking and myosin light chain phosphorylation for vasorelaxation. NO-induced PRKG1 activation also alters gene expression, influencing smooth muscle-specific proteins and limiting smooth muscle cell migration. Additionally, it regulates VASP functions in platelets and smooth muscle. PRKG1 Protein, Human (HEK293, His) is the recombinant human-derived PRKG1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PRKG1 Protein, Human (HEK293, His) is 685 a.a., with molecular weight of ~75.0 kDa.

HY-P74647

	PDE2A Protein, Human (sf9, His) cGMP-dependent 3',5'-cyclic phosphodiesterase; CGS-PDE; PDE2A	Human	Sf9 insect cells
	PDE2A is a cGMP-activated cyclic nucleotide phosphodiesterase that exhibits dual specificity for the second messengers cAMP and cGMP, key regulators in various physiological processes. PDE2A exhibits higher efficiency by covering cAMP and plays an important role in cell growth and migration. PDE2A Protein, Human (sf9, His) is the recombinant human-derived PDE2A protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of PDE2A Protein, Human (sf9, His) is 686 a.a., with molecular weight of ~80.73 kDa.

HY-P702647

	PRKG1 Protein, Human (sf9, GST) PRKG1; protein kinase cGMP-dependent 1; PKG; cGK; AAT8; PKG1; cGK1; cGKI; cGK 1; PRKG1B; PRKGR1B; cGKI-BETA; cGKI-alpha	Human	Sf9 insect cells
	PRKG1 is a serine/threonine protein kinase that mediates the NO/c signaling pathway and phosphorylates various cellular proteins. It affects platelet activation, smooth muscle contraction, cardiac function, central nervous system processes, etc. PRKG1 Protein, Human (sf9, GST) is the recombinant human-derived PRKG1, expressed by Sf9 insect cells , with GST labeled tag. ,

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HY-130530

AP-C5		Alkynes
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC₅₀ of 7.2, which can be used for the research of diarrheal disease . AP-C5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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