PKG inhibitor peptide

Name: PKG inhibitor peptide
Brand: MedChemExpress
SKU: HY-P1292
Rating: 4.5 (1 reviews)

Cat. No.: HY-P1292 Purity: 99.91%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a K_i of 86 μM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PKG inhibitor peptide Chemical Structure

CAS No. : 82801-73-8

Size	Price	Stock	Quantity
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PKG inhibitor peptide:

PKG inhibitor peptide TFA Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a K_i of 86 μM^[1].

IC₅₀ & Target

Ki: 86 μM (PKG)^[1]

In Vitro

Summary of experiments showing that intracellular dialysis of postsynaptic cells with PKG inhibitor PKG inhibitor peptide (1 mM) failed to alter the induction of long-term depression (CCh-LTD)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

943.11

Formula

C₃₈H₇₄N₁₈O₁₀

CAS No.

82801-73-8

Appearance

Solid

Color

White to off-white

Sequence Shortening

RKRARKE

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (106.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (106.03 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0603 mL	5.3016 mL	10.6032 mL
5 mM	0.2121 mL	1.0603 mL	2.1206 mL
10 mM	0.1060 mL	0.5302 mL	1.0603 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (106.03 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.91%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (248 KB) RP-HPLC (199 KB) Elemental Analysis Report (106 KB)

Handling Instructions (2659 KB)

References

[1]. Bhatnagar D, et al. Synthetic peptide analogues differentially alter the binding affinities of cyclic nucleotide dependent protein kinases for nucleotide substrates. Biochemistry. 1988 Mar 22;27(6):1988-94. [Content Brief]

[2]. Chiung-Chun Huang, et al. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex. 2010 Apr;20(4):982-96. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.0603 mL	5.3016 mL	10.6032 mL	26.5080 mL
	5 mM	0.2121 mL	1.0603 mL	2.1206 mL	5.3016 mL
	10 mM	0.1060 mL	0.5302 mL	1.0603 mL	2.6508 mL
	15 mM	0.0707 mL	0.3534 mL	0.7069 mL	1.7672 mL
	20 mM	0.0530 mL	0.2651 mL	0.5302 mL	1.3254 mL
	25 mM	0.0424 mL	0.2121 mL	0.4241 mL	1.0603 mL
	30 mM	0.0353 mL	0.1767 mL	0.3534 mL	0.8836 mL
	40 mM	0.0265 mL	0.1325 mL	0.2651 mL	0.6627 mL
	50 mM	0.0212 mL	0.1060 mL	0.2121 mL	0.5302 mL
	60 mM	0.0177 mL	0.0884 mL	0.1767 mL	0.4418 mL
	80 mM	0.0133 mL	0.0663 mL	0.1325 mL	0.3314 mL
	100 mM	0.0106 mL	0.0530 mL	0.1060 mL	0.2651 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.