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  3. Rp-8-pCPT-cGMPS sodium

Rp-8-pCPT-cGMPS sodium is the sodium salt form of Rp-8-pCPT-cGMPS. Rp-8-pCPT-cGMPS is an inhibitor for cGMP-dependent protein kinase (cGK). Rp-8-pCPT-cGMPS sodium is an agonist for cyclic nucleotide-gated (CNG) channels in a voltage-dependent manner.

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Rp-8-pCPT-cGMPS sodium Chemical Structure

Rp-8-pCPT-cGMPS sodium Chemical Structure

CAS No. : 208445-07-2

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Other Forms of Rp-8-pCPT-cGMPS sodium:

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Description

Rp-8-pCPT-cGMPS sodium is the sodium salt form of Rp-8-pCPT-cGMPS. Rp-8-pCPT-cGMPS is an inhibitor for cGMP-dependent protein kinase (cGK). Rp-8-pCPT-cGMPS sodium is an agonist for cyclic nucleotide-gated (CNG) channels in a voltage-dependent manner[1][2].

In Vivo

Rp-8-pCPT-cGMPS sodium (5 nM, intrathecally, once a day for 3 days) inhibits the cGMP-cGKI pathway, suppresses tumor cell implantation (TCI)-induced thermal hyperalgesia and mechanical allodynia in Sprague-Dawley rats model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bone cancer pain induced by tumor cell implantation (TCI) in Sprague-Dawley rats[1].
Dosage: 0.5 mmol/L, 20 μL
Administration: intrathecally, once a day for 3 days
Result: Delayed and suppressed TCI-induced thermal hyperalgesia and mechanical allodynia.
Molecular Weight

525.86

Formula

C16H14ClN5NaO6PS2

CAS No.
SMILES

O[C@H]1[C@](O[C@@](CO2)([H])[C@@]1([H])O[P@@]2(S[Na])=O)([H])N3C(NC(N)=NC4=O)=C4N=C3SC(C=C5)=CC=C5Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Rp-8-pCPT-cGMPS sodium Related Classifications

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Product Name:
Rp-8-pCPT-cGMPS sodium
Cat. No.:
HY-110221
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