Sp-8-Br-PET-cGMPS

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Sp-8-Br-PET-cGMPS is a membrane-permeable PKG agonist and a membrane-permeable inhibitor of retinal-type cGMP-gated ion channels, as well as an activator of cGMP-dependent protein kinases I α and I β. Sp-8-Br-PET-cGMPS is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, has no metabolic side effects, and is more lipophilic and permeable than Sp-8-pCPT-cGMPS. Sp-8-Br-PET-cGMPS can be used to study the role of cGMP signaling pathways in the nervous system.

For research use only. We do not sell to patients.

Sp-8-Br-PET-cGMPS Chemical Structure

CAS No. : 172806-21-2

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Other Forms of Sp-8-Br-PET-cGMPS:

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Description	Sp-8-Br-PET-cGMPS is a membrane-permeable PKG agonist and a membrane-permeable inhibitor of retinal-type cGMP-gated ion channels, as well as an activator of cGMP-dependent protein kinases I α and I β. Sp-8-Br-PET-cGMPS is resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, has no metabolic side effects, and is more lipophilic and permeable than Sp-8-pCPT-cGMPS. Sp-8-Br-PET-cGMPS can be used to study the role of cGMP signaling pathways in the nervous system^[1].
Molecular Weight	540.28
Formula	C₁₈H₁₅BrN₅O₆PS
CAS No.	172806-21-2
SMILES	O=C1C(N=C(Br)N2[C@H]3[C@H](O)[C@H](O4)[C@@H](CO[P@@]4(S)=O)O3)=C2N=C5N1C=C(C6=CC=CC=C6)N5
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (273 KB) Handling Instructions (2659 KB)
References	[1]. Barnstable, Colin J., Ji-Ye Wei, et al. Modulation of synaptic function by cGMP and cGMP-gated cation channels. Neurochemistry international 45.6 (2004): 875-884. [Content Brief]

Sp-8-Br-PET-cGMPS Related Classifications

Neurological Disease

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sp-8-Br-PET-cGMPS172806-21-2PKGMembrane permeabilityagonistlipophilicitynervous systemInhibitorinhibitorinhibit

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Sp-8-Br-PET-cGMPS

Other Forms of Sp-8-Br-PET-cGMPS:

Sp-8-Br-PET-cGMPS Related Antibodies

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