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Results for "

cereblon-based

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-141481
    DP-C-4

    		PROTACs EGFR PARP Cancer
    DP-C-4 is a Cereblon-based dual PROTAC for simultaneous degradation of EGFR and PARP .
    DP-C-4
  • HY-111870
    PROTAC RIPK degrader-6

    		PROTACs RIP kinase Cancer
    PROTAC RIPK degrader-6 (example 1) is a Cereblon-based PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder .
    PROTAC RIPK degrader-6
  • HY-139186
    PROTAC KRAS G12C degrader-1

    		PROTACs Cancer
    PROTAC KRAS G12C degrader-1 is a Cereblon-based KRAS G12C PROTAC degrader. PROTAC KRAS G12C degrader-1 induces CRBN/ KRAS G12C dimerization and degrades GFP- KRAS G12C in reporter cells .
    PROTAC KRAS G12C degrader-1
  • HY-145615
    Pomalidomide-C12-NH2 hydrochloride

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Pomalidomide-C12-NH2 hydrochloride is the E3 ligase ligand-linker conjugate of PROTAC KRAS G12C degrader-1 (HY-139186). PROTAC KRAS G12C degrader-1 is a Cereblon-based KRAS G12C degrader .
    Pomalidomide-C12-NH2 hydrochloride
  • HY-161233
    BTX-6654

    		PROTACs ERK Cancer
    BTX-6654 is a target-dependent and -specific cereblon-based bifunctional SOS1 PROTAC degrader. BTX-6654 reduces downstream signaling markers pERK and pS6, and displays antiproliferative activity in cells harboring various KRAS mutations .
    BTX-6654
  • HY-139316
    PROTAC IRAK4 degrader-5

    		IRAK PROTACs Cancer
    PROTAC IRAK4 degrader-5 is a Cereblon-based IRAK4 degrader extracted from patent US20190192668A1, compound I-171 .
    PROTAC IRAK4 degrader-5
  • HY-161235
    BTX-7312

    		Molecular Glues Ras Cancer
    BTX-7312 is a cereblon-based SOS1 bifunctional degrader and a molecular glue. BTX-7312 reduces downstream signaling markers pERK and pS6 and shows antiproliferative activity in various KRAS-mutated cells .
    BTX-7312
  • HY-139315
    PROTAC IRAK4 degrader-4

    		PROTACs IRAK Cancer
    PROTAC IRAK4 degrader-4 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-127 .
    PROTAC IRAK4 degrader-4
  • HY-139317
    PROTAC IRAK4 degrader-6

    		PROTACs IRAK Cancer
    PROTAC IRAK4 degrader-6 is a Cereblon-based PROTAC as interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1, compound I-172 .
    PROTAC IRAK4 degrader-6
  • HY-159647
    PLX-4545

    		Molecular Glues Cancer
    PLX-4545 is an orally available, cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios), which can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses .
    PLX-4545
  • HY-168678
    PROTAC K-Ras Degrader-6

    		PROTACs Ras Cancer
    pan-KRAS degrader 5 (compound 102) is a potent cereblon-based KRAS PROTAC degrader, with a DC50 of <100 nM. pan-KRAS degrader 5 shows anticancer effects. (Pink: ligand for target protein (HY-168679); Black: linker (HY-168670); Blue: E3 ligase ligand (HY-W580113)) .
    PROTAC K-Ras Degrader-6
  • HY-168669
    PROTAC K-Ras Degrader-5

    		PROTACs Ras Cancer
    pan-KRAS degrader 4 (compound 69) is a potent cereblon-based KRAS PROTAC degrader, with a DC50 of <100 nM. pan-KRAS degrader 4 shows anticancer effects. (Pink: ligand for target protein (HY-168671); Black: linker (HY-168670); Blue: E3 ligase ligand (HY-W733895)) .
    PROTAC K-Ras Degrader-5
  • HY-129966
    PROTAC IRAK4 degrader-1
    1 Publications Verification

    		 PROTACs IRAK Cancer
    PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively .
    PROTAC IRAK4 degrader-1
  • HY-122653
    CCT367766

    		PROTACs Cancer
    CCT367766 is a potent and the third generation?heterobifunctional and Cereblon-based pirin targeting protein?degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 exhibits a moderate affinity for the CRBN-DDB1 complex with an?IC50?value of 490 nM. CCT367766 reveals a good affinity for the recombinant pirin and CRBN with?Kd?values of 55 nM and 120 nM, respectively. CCT367766 provides a potential chemical tool to study a largely unexplored protein .
    CCT367766
  • HY-122653A
    CCT367766 formic

    		PROTACs Cancer
    CCT367766 formic is a potent and the third generation heterobifunctional and Cereblon-based pirin targeting protein degradation probe (PDP, or PROTAC), depletes pirin protein expression at low concentration. CCT367766 formic exhibits a moderate affinity for the CRBN-DDB1 complex with an IC50 value of 490 nM. CCT367766 formic reveals a good affinity for the recombinant pirin and CRBN with Kd values of 55 nM and 120 nM, respectively. CCT367766 formic provides a potential chemical tool to study a largely unexplored protein .
    CCT367766 formic
  • HY-161574
    LLC0424

    		PROTACs Histone Methyltransferase Cancer
    LLC0424 is a potent and selective cereblon-based PROTAC nuclear receptor-binding SET domain-containing 2 (NSD2) degrader. LLC0424 effectively degraded NSD2 with a DC50 of 20 nM in RPMI-8402 cells. LLC0424 selectively induces NSD2 degradation in a cereblon- and proteasome-dependent fashion. (Blue: CRBN ligand (HY-14658), Black: linker (HY-40002); Pink: NSD2 inhibitor (HY-161575)) .
    LLC0424
  • HY-168637
    SIAIS562055

    		PROTACs Ras Cancer
    SIAIS562055 is a potent cereblon-based SOS1 PROTAC with a Kd of 95.9 nM. SIAIS562055 exhibits sustained degradation of SOS1 and inhibition of downstream ERK pathways. SIAIS562055 effectively blocked the binding of KRAS G12C or KRAS G12D to SOS1, with the IC50 values of 95.7 nM and 134.5 nM, respectively. SIAIS562055 exhibits potent anticancer activity. (Pink: SOS1 ligand (HY-168638); Black: linker (HY-W539874); Blue: E3 ligase ligand (HY-W076696)) .
    SIAIS562055
  • HY-163210
    Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride

    		Ligands for E3 Ligase Cancer
    Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride (ZJT1) is an E3 ubiquitin ligase cereblon based on Pomalidomide (HY-10984) (CRBN) ligand for recruitment of cereblon protein. Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride can be linked to protein ligand by linker to form PROTAC .
    Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride

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