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  4. PROTAC KRAS G12C degrader-1

PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C PROTAC degrader. PROTAC KRAS G12C degrader-1 induces CRBN/ KRASG12C dimerization and degrades GFP- KRASG12C in reporter cells.

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PROTAC KRAS G12C degrader-1 Chemical Structure

PROTAC KRAS G12C degrader-1 Chemical Structure

CAS No. : 2984236-79-3

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1 mg USD 582 In-stock
5 mg USD 1280 In-stock
10 mg USD 2050 In-stock
25 mg USD 4250 In-stock
50 mg USD 6800 In-stock
100 mg USD 10880 In-stock
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Based on 1 publication(s) in Google Scholar

PROTAC KRAS G12C degrader-1 Related Antibodies

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Description

PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C PROTAC degrader. PROTAC KRAS G12C degrader-1 induces CRBN/ KRASG12C dimerization and degrades GFP- KRASG12C in reporter cells[1].

In Vitro

PROTAC KRAS G12C degrader-1 (Compound 10) engages CRBN in cells, bound KRASG12C in vitro, induces CRBN/KRASG12C dimerization, and degrades GFP-KRASG12C in reporter cells in a CRBN-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC KRAS G12C degrader-1 Related Antibodies
Molecular Weight

917.47

Formula

C50H54ClFN8O6
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

OC1=CC2=C(C(C3=C(C4=C(C=C3Cl)C(N5CCN(CC5)C(C=C)=O)=NC(NCCCCCCCCCCCCNC6=C(C7=CC=C6)C(N(C7=O)C8CCC(NC8=O)=O)=O)=N4)F)=C1)C=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (109.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0900 mL 5.4498 mL 10.8995 mL
5 mM 0.2180 mL 1.0900 mL 2.1799 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0900 mL 5.4498 mL 10.8995 mL 27.2488 mL
5 mM 0.2180 mL 1.0900 mL 2.1799 mL 5.4498 mL
10 mM 0.1090 mL 0.5450 mL 1.0900 mL 2.7249 mL
15 mM 0.0727 mL 0.3633 mL 0.7266 mL 1.8166 mL
20 mM 0.0545 mL 0.2725 mL 0.5450 mL 1.3624 mL
25 mM 0.0436 mL 0.2180 mL 0.4360 mL 1.0900 mL
30 mM 0.0363 mL 0.1817 mL 0.3633 mL 0.9083 mL
40 mM 0.0272 mL 0.1362 mL 0.2725 mL 0.6812 mL
50 mM 0.0218 mL 0.1090 mL 0.2180 mL 0.5450 mL
60 mM 0.0182 mL 0.0908 mL 0.1817 mL 0.4541 mL
80 mM 0.0136 mL 0.0681 mL 0.1362 mL 0.3406 mL
100 mM 0.0109 mL 0.0545 mL 0.1090 mL 0.2725 mL
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PROTAC KRAS G12C degrader-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC KRAS G12C degrader-12984236-79-3PROTACsKRASG12CCRBNInhibitorinhibitorinhibit

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PROTAC KRAS G12C degrader-1
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