2. PROTAC MAPK/ERK Pathway Stem Cell/Wnt
  3. PROTACs ERK
  4. BTX-6654

BTX-6654 is a target-dependent and -specific cereblon-based bifunctional SOS1 PROTAC degrader. BTX-6654 reduces downstream signaling markers pERK and pS6, and displays antiproliferative activity in cells harboring various KRAS mutations.

For research use only. We do not sell to patients.

BTX-6654 Chemical Structure

BTX-6654 Chemical Structure

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BTX-6654 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All ERK Isoform Specific Products:

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ERK ERK1 ERK2 ERK5 ERK8

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Description

BTX-6654 is a target-dependent and -specific cereblon-based bifunctional SOS1 PROTAC degrader. BTX-6654 reduces downstream signaling markers pERK and pS6, and displays antiproliferative activity in cells harboring various KRAS mutations[1].

Molecular Weight

940.04

Formula

C50H57F4N9O5
SMILES

FC(F)(F)C1=C(C)C([C@@H](C)NC2=NN=C(C)C3=CC=C(N4CCN(C(C5CCN(C(CCN6CCC(C7=CC(CN(C8CCC(NC8=O)=O)C9=O)=C9C=C7F)CC6)=O)CC5)=O)CC4)C=C32)=CC=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BTX-6654 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BTX-6654BTX6654BTX 6654PROTACsERKExtracellular signal regulated kinasesSOS1 degradercereblon-basedKRASInhibitorinhibitorinhibit

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