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Results for "

class II HDAC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	HDAC (16) Apoptosis (10) Autophagy (5) Filovirus (3) HPV (3) Mitophagy (5) Monoamine Transporter (1) NF-κB (2) Organoid (1) PI3K (2) Sirtuin (1)
By Research Areas:	Cancer (18) Infection (4) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Targets Recommended: HDAC Photosystem II Scavenger Receptor Class B type I (SR-BI） CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15144

Trichostatin A Maximum Cited Publications 131 Publications Verification TSA	Organoid HDAC	Cancer
Trichostatin A (TSA) is a potent and specific inhibitor of **HDAC class I/II, with an IC₅₀** value of 1.8 nM for HDAC .

HY-16914

MC1568 5+ Cited Publications	HDAC	Cancer
MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor, used for cancer research.

HY-10221

Vorinostat 105+ Cited Publications SAHA; Suberoylanilide hydroxamic acid	HDAC Autophagy Mitophagy Filovirus Apoptosis HPV	Infection Cancer
Vorinostat (SAHA) is a potent and orally active pan-inhibitor of *HDAC1, HDAC2* and HDAC3 (Class I), *HDAC6* and **HDAC7 (Class II)** and HDAC11 (Class IV), with ID₅₀ values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis . Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification .

HY-100748

Zabadinostat 2 Publications Verification CXD101	HDAC	Cancer
Zabadinostat (CXD101) is a potent, selective and orally active class I *HDAC* inhibitor with IC₅₀s of 63 nM, 570 nM and 550 nM for *HDAC1, HDAC2* and *HDAC3, respectively. Zabadinostat has no activity against HDAC* class II. Zabadinostat has antitumor activity .

HY-117554

BRD9757	HDAC	Cancer
BRD9757 is a potent, capless and selective *HDAC6* inhibitor with an IC₅₀ of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs .

HY-115412

Vorinostat-d5 SAHA-d5; Suberoylanilide hydroxamic acid-d5	HDAC Autophagy Mitophagy Filovirus Apoptosis HPV	Infection Cancer
Vorinostat-d5 (SAHA-d5) is the deuterium labeled Vorinostat. Vorinostat (SAHA) is a potent and orally active pan-inhibitor of *HDAC1, HDAC2* and HDAC3 (Class I), **HDAC7 (Class II)** and HDAC11 (Class IV), with ID₅₀ values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis . Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification .

HY-13522

Fimepinostat 10+ Cited Publications CUDC-907	PI3K HDAC Apoptosis	Cancer
Fimepinostat (CUDC-907) potently inhibits class I PI3Ks as well as classes I and II *HDAC* enzymes with an IC₅₀ of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively.

HY-149208

HDAC-IN-53	HDAC Apoptosis	Cancer
HDAC-IN-53 is an orally active, and selective *HDAC1-3* inhibitor with IC₅₀ values of 47 nM, 125 nM, and 450 nM, respectively. HDAC-IN-53 does not inhibit class II HDACs (HDAC4, 5, 6, 7, 9; IC₅₀>10 μM). HDAC-IN-53 induces caspase-dependent apoptosis. HDAC-IN-53 significantly inhibits the growth of human tumor xenografts in nude mice and murine tumor growth in immune-competent mice bearing MC38 colon cancer .

HY-10221G

Vorinostat (GMP) SAHA (GMP); Suberoylanilide hydroxamic acid (GMP)	HDAC	Infection Cancer
Vorinostat (GMP) is a GMP grade Vorinosta (HY-10221). GMP-grade small molecules can be used as auxiliary agents in cell therapy. Vorinostat is a potent, orally available **HDAC1, HDAC2, HDAC3 (Class I), HDAC6** and Inhibitors of HDAC7 (Class II) and **Class IV (HDAC11)** .

HY-10221R

Vorinostat (Standard)	HDAC Autophagy Mitophagy Filovirus Apoptosis HPV	Infection Cancer
Vorinostat (Standard) is the analytical standard of Vorinostat. This product is intended for research and analytical applications. Vorinostat (SAHA) is a potent and orally active pan-inhibitor of *HDAC1, HDAC2* and HDAC3 (Class I), *HDAC6* and **HDAC7 (Class II)** and HDAC11 (Class IV), with ID₅₀ values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis . Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification .

HY-155890

Fimepinostat mesylate CUDC-907 mesylate	PI3K HDAC Apoptosis	Cancer
Fimepinostat mesylate potently inhibits class I PI3Ks as well as classes I and II *HDAC* enzymes with an IC₅₀ of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively.

HY-130538

1-Naphthohydroxamic acid 1 Publications Verification	HDAC	Cancer
1-Naphthohydroxamic acid (Compound 2) is a potent and selective *HDAC8* inhibitor with an IC₅₀ of 14 μM. 1-Naphthohydroxamic acid is more selectively for *HDAC8* than class I HDAC1 and class II HDAC6 (IC₅₀ >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity .1-Naphthohydroxamic acid can induce tubulin acetylation .

HY-N0141

Parthenolide 25+ Cited Publications (-)-Parthenolide	NF-κB Autophagy Mitophagy Apoptosis	Cancer
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits *HDAC1* protein without affecting other class I/II HDACs.

HY-109109

Alteminostat CKD-581	HDAC Apoptosis	Cancer
Alteminostat (CKD-581) is a potent *HDAC* inhibitor. Alteminostat inhibits the class I-II *HDAC* family via histone H3 and tubulin acetylation. Alteminostat can be used for lymphoma and multiple myeloma research .

HY-124946

C1A	HDAC Sirtuin Apoptosis	Cancer
C1A is a **class I/II HDACs and sirtuin inhibitor with an IC₅₀ of 479 nM for HDAC6*. C1A induces sustained acetylation of HDAC6 substrates, α-tubulin and HSP90. C1A shows srtong anticancer effcts, and induces apoptosis* in cancer cells .

HY-19348

Pimelic Diphenylamide 106 4 Publications Verification RGFA-8; TC-H 106; Histone Deacetylase Inhibitor VII	HDAC Monoamine Transporter	Neurological Disease Cancer
Pimelic Diphenylamide 106 (TC-H 106) is a slow, tight binding class I *HDAC* inhibitor (inhibits *HDAC1, 2, and 3 with IC₅₀* values of 150 nM, 760 nM, and 370 nM, respectively), with no activity against class II *HDACs. Pimelic Diphenylamide 106 modulates dopamine concentration and protects dopamine cells by inducing VMAT2* expression. Pimelic Diphenylamide 106 can be used in the study of neuropsychiatric diseases such as attention deficit hyperactivity disorder (ADHD) .

HY-N0141R

Parthenolide (Standard)	NF-κB Autophagy Mitophagy Apoptosis	Cancer
Parthenolide (Standard) is the analytical standard of Parthenolide. This product is intended for research and analytical applications. Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.

HY-124007

4-Iodo-SAHA ISAHA	HDAC	Cancer
4-Iodo-SAHA (1k) is an orally active class I and class II histone deacetylase (HDAC) inhibitor with EC₅₀s of 1.1, 0.95, 0.12, 0.24, 0.85 and 1.3 μM for Skbr3, HT29, U937, JA16 and HL60 cell lines, respectively. 4-Iodo-SAHA (1k) can be used for the research of cancer .

Cat. No.	Product Name	Type

HY-10221G

Vorinostat (GMP) SAHA (GMP); Suberoylanilide hydroxamic acid (GMP)	Fluorescent Dye
Vorinostat (GMP) is a GMP grade Vorinosta (HY-10221). GMP-grade small molecules can be used as auxiliary agents in cell therapy. Vorinostat is a potent, orally available **HDAC1, HDAC2, HDAC3 (Class I), HDAC6** and Inhibitors of HDAC7 (Class II) and **Class IV (HDAC11)** .

Cat. No.	Product Name	Type

HY-10221G

Vorinostat (GMP) SAHA (GMP); Suberoylanilide hydroxamic acid (GMP)	Biochemical Assay Reagents
Vorinostat (GMP) is a GMP grade Vorinosta (HY-10221). GMP-grade small molecules can be used as auxiliary agents in cell therapy. Vorinostat is a potent, orally available **HDAC1, HDAC2, HDAC3 (Class I), HDAC6** and Inhibitors of HDAC7 (Class II) and **Class IV (HDAC11)** .

Trichostatin A 130+ Cited Publications TSA	Structural Classification Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Organoid HDAC
Trichostatin A (TSA) is a potent and specific inhibitor of **HDAC class I/II, with an IC₅₀** value of 1.8 nM for HDAC .

Parthenolide 25+ Cited Publications (-)-Parthenolide	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Euchresta formosana (Hayata) Ohwi Disease Research Fields Cancer	NF-κB Autophagy Mitophagy Apoptosis
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits *HDAC1* protein without affecting other class I/II HDACs.

Parthenolide (Standard)	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Euchresta formosana (Hayata) Ohwi	NF-κB Autophagy Mitophagy Apoptosis
Parthenolide (Standard) is the analytical standard of Parthenolide. This product is intended for research and analytical applications. Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.

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class II HDAC

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

NaturalProducts

Natural
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