2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. Alteminostat

Alteminostat  (Synonyms: CKD-581)

Cat. No.: HY-109109 Purity: 98.66%
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Alteminostat (CKD-581) is a potent HDAC inhibitor. Alteminostat inhibits the class I-II HDAC family via histone H3 and tubulin acetylation. Alteminostat can be used for lymphoma and multiple myeloma research.

For research use only. We do not sell to patients.

Alteminostat Chemical Structure

Alteminostat Chemical Structure

CAS No. : 1246374-97-9

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5 mg USD 450 In-stock
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Based on 1 publication(s) in Google Scholar

Alteminostat Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • Biological Activity

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Description

Alteminostat (CKD-581) is a potent HDAC inhibitor. Alteminostat inhibits the class I-II HDAC family via histone H3 and tubulin acetylation. Alteminostat can be used for lymphoma and multiple myeloma research[1].

In Vitro

Alteminostat (CKD-581; 1 nM-10 μM; 72 hours) treatment potently reduces cell viability in all four lymphoma cell lines in a concentration-dependent manner. The IC50 values of Alteminostat in SU-DHL-4, OCI-LY1, SU-DHL-2, and U2932 cells are 1.31 nM, 36.91 nM, 1.18 nM, and 31.99 nM, respectively[1].
Alteminostat (CKD-581; 10-300 nM; 24 hours) treatment decreases the expression of BCL-6 as well as BCL-2 in cells[1].
Alteminostat (CKD-581; 30-300 nM; 24 h) treatment results in γH2AX accumulation and PARP1 cleavage in SU-DHL-4, OCI-LY1, SU-DHL-2, and U2932 cells. Alteminostat decreases the protein levels of BCL-XL and MCL-1 in a concentration-dependent manner in OCI-LY1 cells[1].
Alteminostat (CKD-581; 10-300 nM; 6 hours) treatment increases the acetylation of histone H3 in SU-DHL-2 cells. And tubulin acetylation also increased with 10 nM CKD-581. CKD-581 increased the acetylation of target molecules by inhibiting class I-II HDACs in lymphoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alteminostat Related Antibodies

Cell Viability Assay[1]

Cell Line: SU-DHL-4, OCI-LY1, SU-DHL-2, and U2932 cells
Concentration: 1 nM-10 μM
Incubation Time: 72 hours
Result: Potently reduced cell viability in all four lymphoma cell lines in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: SU-DHL-4 and OCI-LY1 cells
Concentration: 10 nM, 30 nM, 100 nM, 300 nM
Incubation Time: 24 hours
Result: Decreased the expression of BCL-6 as well as BCL-2 in cells.
In Vivo

Alteminostat (CKD-581; 20-40 mg/kg; ntraperitoneal injection; twice a week; for 4 weeks) treatment partially but significantly suppresses tumor growth in SU-DHL-4 xenograft mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NOD.CB17 SCID injected with SU-DHL-4 cells[1]
Dosage: 20 mg/kg or 40 mg/kg
Administration: Intraperitoneal injection; twice a week; for 4 weeks
Result: Partially but significantly suppressed tumor growth.
Clinical Trial
Molecular Weight

492.61

Formula

C27H36N6O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1CCN(C)CC1)N(CCCCCCC(NO)=O)C2=CC=C(C3=CC4=C(C=C3)C=NN4C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 230 mg/mL (466.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0300 mL 10.1500 mL 20.3000 mL
5 mM 0.4060 mL 2.0300 mL 4.0600 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0300 mL 10.1500 mL 20.3000 mL 50.7501 mL
5 mM 0.4060 mL 2.0300 mL 4.0600 mL 10.1500 mL
10 mM 0.2030 mL 1.0150 mL 2.0300 mL 5.0750 mL
15 mM 0.1353 mL 0.6767 mL 1.3533 mL 3.3833 mL
20 mM 0.1015 mL 0.5075 mL 1.0150 mL 2.5375 mL
25 mM 0.0812 mL 0.4060 mL 0.8120 mL 2.0300 mL
30 mM 0.0677 mL 0.3383 mL 0.6767 mL 1.6917 mL
40 mM 0.0508 mL 0.2538 mL 0.5075 mL 1.2688 mL
50 mM 0.0406 mL 0.2030 mL 0.4060 mL 1.0150 mL
60 mM 0.0338 mL 0.1692 mL 0.3383 mL 0.8458 mL
80 mM 0.0254 mL 0.1269 mL 0.2538 mL 0.6344 mL
100 mM 0.0203 mL 0.1015 mL 0.2030 mL 0.5075 mL
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Alteminostat Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alteminostat1246374-97-9CKD-581CKD581CKD 581HDACApoptosisHistone deacetylasesLymphomamyelomaanticancerγH2AXacetylationPARP1apoptosisBCL-2BCL-6BCL-XLInhibitorinhibitorinhibit

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