2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. BRD9757

BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs.

For research use only. We do not sell to patients.

BRD9757 Chemical Structure

BRD9757 Chemical Structure

CAS No. : 1423058-85-8

Size Price Stock Quantity
5 mg USD 100 In-stock
10 mg USD 150 In-stock
25 mg USD 290 In-stock
50 mg USD 435 In-stock
100 mg USD 652 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

BRD9757 Related Antibodies

Top Publications Citing Use of Products

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs[1].

IC50 & Target[1]

HDAC6

0.03 μM (IC50)

HDAC1

0.638 μM (IC50)

HDAC2

1.79 μM (IC50)

HDAC3

0.694 μM (IC50)

HDAC4

21.80 μM (IC50)

HDAC5

18.32 μM (IC50)

HDAC7

12.61 μM (IC50)

HDAC8

1.09 μM (IC50)

HDAC9

>33.33 μM (IC50)

In Vitro

BRD9757 (compound 14) against HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8, and HDAC9 with IC50 values of 0.638 μM, 1.79 μM, 0.694 μM, 21.80 μM, 18.32 μM, 12.61 μM, 1.09 μM, and >33.33 μM, respectively[1].
BRD9757 (compound 14; 10-30 μM; 24 h) selectively increases the level of Ac-tubulin, without increasing histone acetylation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BRD9757 Related Antibodies

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 10 μM and 30 μM
Incubation Time: for 24 h
Result: Increased the level of Ac-tubulin.
Molecular Weight

127.14

Formula

C6H9NO2
CAS No.
Appearance

Solid

Color

Light yellow to khaki

SMILES

O=C(C1=CCCC1)NO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 12.5 mg/mL (98.32 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.8653 mL 39.3267 mL 78.6535 mL
5 mM 1.5731 mL 7.8653 mL 15.7307 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.8653 mL 39.3267 mL 78.6535 mL 196.6336 mL
5 mM 1.5731 mL 7.8653 mL 15.7307 mL 39.3267 mL
10 mM 0.7865 mL 3.9327 mL 7.8653 mL 19.6634 mL
15 mM 0.5244 mL 2.6218 mL 5.2436 mL 13.1089 mL
20 mM 0.3933 mL 1.9663 mL 3.9327 mL 9.8317 mL
25 mM 0.3146 mL 1.5731 mL 3.1461 mL 7.8653 mL
30 mM 0.2622 mL 1.3109 mL 2.6218 mL 6.5545 mL
40 mM 0.1966 mL 0.9832 mL 1.9663 mL 4.9158 mL
50 mM 0.1573 mL 0.7865 mL 1.5731 mL 3.9327 mL
60 mM 0.1311 mL 0.6554 mL 1.3109 mL 3.2772 mL
80 mM 0.0983 mL 0.4916 mL 0.9832 mL 2.4579 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

BRD9757 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD97571423058-85-8BRD 9757BRD-9757HDACHistone deacetylasesHDAC6 inhibitorcaplessAc-tubulinInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
BRD9757
Cat. No.:
HY-117554
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (393 KB) Français - FR (393 KB) Deutsch - DE (393 KB) Norwegian - NO (393 KB) Español - ES (393 KB) Swedish - SV (393 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.