1. Cell Cycle/DNA Damage Epigenetics
  2. HDAC
  3. BRD9757

BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs.

For research use only. We do not sell to patients.

BRD9757 Chemical Structure

BRD9757 Chemical Structure

CAS No. : 1423058-85-8

Size Price Stock Quantity
5 mg USD 100 In-stock
10 mg USD 150 In-stock
25 mg USD 290 In-stock
50 mg USD 435 In-stock
100 mg USD 652 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs[1].

IC50 & Target[1]

HDAC6

0.03 μM (IC50)

HDAC1

0.638 μM (IC50)

HDAC2

1.79 μM (IC50)

HDAC3

0.694 μM (IC50)

HDAC4

21.80 μM (IC50)

HDAC5

18.32 μM (IC50)

HDAC7

12.61 μM (IC50)

HDAC8

1.09 μM (IC50)

HDAC9

>33.33 μM (IC50)

In Vitro

BRD9757 (compound 14) against HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8, and HDAC9 with IC50 values of 0.638 μM, 1.79 μM, 0.694 μM, 21.80 μM, 18.32 μM, 12.61 μM, 1.09 μM, and >33.33 μM, respectively[1].
BRD9757 (compound 14; 10-30 μM; 24 h) selectively increases the level of Ac-tubulin, without increasing histone acetylation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HeLa cells
Concentration: 10 μM and 30 μM
Incubation Time: for 24 h
Result: Increased the level of Ac-tubulin.
Molecular Weight

127.14

Formula

C6H9NO2

CAS No.
Appearance

Solid

Color

Light yellow to khaki

SMILES

O=C(C1=CCCC1)NO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 12.5 mg/mL (98.32 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.8653 mL 39.3267 mL 78.6535 mL
5 mM 1.5731 mL 7.8653 mL 15.7307 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.8653 mL 39.3267 mL 78.6535 mL 196.6336 mL
5 mM 1.5731 mL 7.8653 mL 15.7307 mL 39.3267 mL
10 mM 0.7865 mL 3.9327 mL 7.8653 mL 19.6634 mL
15 mM 0.5244 mL 2.6218 mL 5.2436 mL 13.1089 mL
20 mM 0.3933 mL 1.9663 mL 3.9327 mL 9.8317 mL
25 mM 0.3146 mL 1.5731 mL 3.1461 mL 7.8653 mL
30 mM 0.2622 mL 1.3109 mL 2.6218 mL 6.5545 mL
40 mM 0.1966 mL 0.9832 mL 1.9663 mL 4.9158 mL
50 mM 0.1573 mL 0.7865 mL 1.5731 mL 3.9327 mL
60 mM 0.1311 mL 0.6554 mL 1.3109 mL 3.2772 mL
80 mM 0.0983 mL 0.4916 mL 0.9832 mL 2.4579 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
BRD9757
Cat. No.:
HY-117554
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